Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992823705> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1992823705 abstract "Focal segmental glomerulosclerosis (FSGS) is a primary glomerular disease that usually progresses to renal failure. Although high-dose pulse methylprednisolone therapy (PMT) has been shown to be effective in the treatment of steroid-resistant FSGS, adverse effects have caused parents to hesitate in approving the treatment. The aim of this study is to investigate whether low-dose PMT based protocol for treatment of young children with steroid resistant FSGS would effectively induce remission of proteinuria and prevent the progression of renal insufficiency.This is a retrospective study. The authors treated eight children with steroid-resistant FSGS with intravenous methylprednisolone pulse 10 mg/kg per day for three consecutive days weekly for 8 weeks. Partial responders were treated with the addition of chlorambucil or cyclosporine (CsA) and four fortnightly and eight monthly pulses of high-dose PMT (30 mg/kg per day).Of the eight patients, six attained complete remission initially. The median urinary protein excretion in 24 h decreased from 4.25 to 0.39 g following 8 weeks of low dose (P = 0.012). Marked decrease in urinary protein-creatinine ratio was noted soon after treatment (P = 0.012). There was a significant increase in serum albumin level after treatment compared to the pretreatment condition (median, 3.35 vs 4.1 mg/dL, P = 0.018). Five of the eight patients remained in complete remission, and one of the eight patients relapsed during follow up. Relapse responded to repeated treatments of PMT and cyclosporine. The two patients with partial remission initially progressed to renal insufficiency in one patient and end-stage renal disease in the other patient.Low-dose PMT caused a significant decrease in the proteinuria of Chinese children with steroid-resistant FSGS with a low frequency of intolerance." @default.
- W1992823705 created "2016-06-24" @default.
- W1992823705 creator A5003751733 @default.
- W1992823705 creator A5041014218 @default.
- W1992823705 creator A5060278143 @default.
- W1992823705 date "2007-06-01" @default.
- W1992823705 modified "2023-09-24" @default.
- W1992823705 title "Low-dose methylprednisolone pulse therapy in Chinese children with steroid resistant focal segmental glomerulosclerosis" @default.
- W1992823705 cites W1974796597 @default.
- W1992823705 cites W1980225865 @default.
- W1992823705 cites W2017629206 @default.
- W1992823705 cites W2021202287 @default.
- W1992823705 cites W2021813090 @default.
- W1992823705 cites W2026925771 @default.
- W1992823705 cites W2027328052 @default.
- W1992823705 cites W2030609234 @default.
- W1992823705 cites W2044187650 @default.
- W1992823705 cites W2053680475 @default.
- W1992823705 cites W2054225562 @default.
- W1992823705 cites W2059769088 @default.
- W1992823705 cites W2088623598 @default.
- W1992823705 cites W2089345163 @default.
- W1992823705 cites W2110230080 @default.
- W1992823705 cites W2113788079 @default.
- W1992823705 cites W2136982039 @default.
- W1992823705 cites W2175322775 @default.
- W1992823705 cites W2323753285 @default.
- W1992823705 cites W2397709570 @default.
- W1992823705 doi "https://doi.org/10.1111/j.1442-200x.2007.02373.x" @default.
- W1992823705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17532834" @default.
- W1992823705 hasPublicationYear "2007" @default.
- W1992823705 type Work @default.
- W1992823705 sameAs 1992823705 @default.
- W1992823705 citedByCount "1" @default.
- W1992823705 crossrefType "journal-article" @default.
- W1992823705 hasAuthorship W1992823705A5003751733 @default.
- W1992823705 hasAuthorship W1992823705A5041014218 @default.
- W1992823705 hasAuthorship W1992823705A5060278143 @default.
- W1992823705 hasConcept C10146269 @default.
- W1992823705 hasConcept C126322002 @default.
- W1992823705 hasConcept C126894567 @default.
- W1992823705 hasConcept C159641895 @default.
- W1992823705 hasConcept C197934379 @default.
- W1992823705 hasConcept C2776379505 @default.
- W1992823705 hasConcept C2776694085 @default.
- W1992823705 hasConcept C2776755627 @default.
- W1992823705 hasConcept C2777390665 @default.
- W1992823705 hasConcept C2777747828 @default.
- W1992823705 hasConcept C2777866208 @default.
- W1992823705 hasConcept C2778198053 @default.
- W1992823705 hasConcept C2778415529 @default.
- W1992823705 hasConcept C2778930706 @default.
- W1992823705 hasConcept C2779561371 @default.
- W1992823705 hasConcept C2780091579 @default.
- W1992823705 hasConcept C2780306776 @default.
- W1992823705 hasConcept C2780372218 @default.
- W1992823705 hasConcept C71924100 @default.
- W1992823705 hasConcept C77411442 @default.
- W1992823705 hasConcept C90924648 @default.
- W1992823705 hasConceptScore W1992823705C10146269 @default.
- W1992823705 hasConceptScore W1992823705C126322002 @default.
- W1992823705 hasConceptScore W1992823705C126894567 @default.
- W1992823705 hasConceptScore W1992823705C159641895 @default.
- W1992823705 hasConceptScore W1992823705C197934379 @default.
- W1992823705 hasConceptScore W1992823705C2776379505 @default.
- W1992823705 hasConceptScore W1992823705C2776694085 @default.
- W1992823705 hasConceptScore W1992823705C2776755627 @default.
- W1992823705 hasConceptScore W1992823705C2777390665 @default.
- W1992823705 hasConceptScore W1992823705C2777747828 @default.
- W1992823705 hasConceptScore W1992823705C2777866208 @default.
- W1992823705 hasConceptScore W1992823705C2778198053 @default.
- W1992823705 hasConceptScore W1992823705C2778415529 @default.
- W1992823705 hasConceptScore W1992823705C2778930706 @default.
- W1992823705 hasConceptScore W1992823705C2779561371 @default.
- W1992823705 hasConceptScore W1992823705C2780091579 @default.
- W1992823705 hasConceptScore W1992823705C2780306776 @default.
- W1992823705 hasConceptScore W1992823705C2780372218 @default.
- W1992823705 hasConceptScore W1992823705C71924100 @default.
- W1992823705 hasConceptScore W1992823705C77411442 @default.
- W1992823705 hasConceptScore W1992823705C90924648 @default.
- W1992823705 hasLocation W19928237051 @default.
- W1992823705 hasLocation W19928237052 @default.
- W1992823705 hasOpenAccess W1992823705 @default.
- W1992823705 hasPrimaryLocation W19928237051 @default.
- W1992823705 hasRelatedWork W1894184984 @default.
- W1992823705 hasRelatedWork W1992823705 @default.
- W1992823705 hasRelatedWork W2026925771 @default.
- W1992823705 hasRelatedWork W2042172609 @default.
- W1992823705 hasRelatedWork W2042825917 @default.
- W1992823705 hasRelatedWork W2104395416 @default.
- W1992823705 hasRelatedWork W2887063248 @default.
- W1992823705 hasRelatedWork W4248765236 @default.
- W1992823705 hasRelatedWork W590017911 @default.
- W1992823705 hasRelatedWork W67147402 @default.
- W1992823705 isParatext "false" @default.
- W1992823705 isRetracted "false" @default.
- W1992823705 magId "1992823705" @default.
- W1992823705 workType "article" @default.