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- W1992830991 abstract "Binding of three macrocyclic bis-intercalators, derivatives of acridine and naphthalene, and two acyclic model compounds to mismatch-containing and matched duplex oligodeoxynucleotides was analyzed by thermal denaturation experiments, electrospray ionization mass spectrometry studies (ESI-MS) and fluorescent intercalator displacement (FID) titrations. The macrocyclic bis-intercalators bind to duplexes containing mismatched thymine bases with high selectivity over the fully matched ones, whereas the acyclic model compounds are much less selective and strongly bind to the matched DNA. Moreover, the results from thermal denaturation experiments are in very good agreement with the binding affinities obtained by ESI-MS and FID measurements. The FID results also demonstrate that the macrocyclic naphthalene derivative BisNP preferentially binds to pyrimidine–pyrimidine mismatches compared to all other possible base mismatches. This ligand also efficiently competes with a DNA enzyme (M.TaqI) for binding to a duplex with a TT-mismatch, as shown by competitive fluorescence titrations. Altogether, our results demonstrate that macrocyclic distance-constrained bis-intercalators are efficient and selective mismatch-binding ligands that can interfere with mismatch-binding enzymes." @default.
- W1992830991 created "2016-06-24" @default.
- W1992830991 creator A5002465422 @default.
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- W1992830991 creator A5018982548 @default.
- W1992830991 creator A5032046128 @default.
- W1992830991 creator A5046831416 @default.
- W1992830991 date "2008-08-01" @default.
- W1992830991 modified "2023-10-10" @default.
- W1992830991 title "Selective recognition of pyrimidine–pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators" @default.
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- W1992830991 doi "https://doi.org/10.1093/nar/gkn392" @default.
- W1992830991 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2528167" @default.
- W1992830991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18658249" @default.
- W1992830991 hasPublicationYear "2008" @default.
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