Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992840257> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1992840257 endingPage "398" @default.
- W1992840257 startingPage "392" @default.
- W1992840257 abstract "From the leaves of Withania somnifera L. Dunal, a new withasteroid named as 5,6-de-epoxy-5-en-7-one-17-hydroxy withaferin A (6) was isolated along with several known compounds, namely 16β-acetoxy-6α,7α-epoxy-5α-hydroxy-1-oxowitha-2,17(20),24-trienolide (1), withanone (2), 16-en-27-deoxy withaferin A (3), 27-deoxy withaferin A (4), withaferin A (5), withanolide D (7) and 27-hydroxy withanone (8). Its structure was determined using spectroscopic methods, namely IR, 1H NMR, 13C NMR, COSY, HMBC and HRMS. Among the known compounds, 16β-acetoxy-6α,7α-epoxy-5α-hydroxy-1-oxowitha-2,17(20),24-trienolide (1) was previously reported from the roots of W. somnifera. Now, it has been isolated from the leaves, as well. The cytotoxic activity of the new steroid was carried out using the MTT assay against a panel of cancer cell lines, namely MCF-7 (breast), WRL-68 (liver), PC-3 (prostate) and CACO-2 (colon). The results showed that the new compound possesses strong cytotoxic activity against liver and breast cancer with an IC50 of 1.0 μg/mL and a moderate activity against colon (IC50 3.4 μg/mL) and prostate (IC50 7.4 μg/mL) cancer cells." @default.
- W1992840257 created "2016-06-24" @default.
- W1992840257 creator A5036774756 @default.
- W1992840257 creator A5037263821 @default.
- W1992840257 creator A5051484473 @default.
- W1992840257 creator A5083558391 @default.
- W1992840257 creator A5085349807 @default.
- W1992840257 date "2014-01-14" @default.
- W1992840257 modified "2023-10-02" @default.
- W1992840257 title "5,6-De-epoxy-5-en-7-one-17-hydroxy withaferin A, a new cytotoxic steroid from<i>Withania somnifera</i>L. Dunal leaves" @default.
- W1992840257 cites W1982340634 @default.
- W1992840257 cites W1987562602 @default.
- W1992840257 cites W1991375341 @default.
- W1992840257 cites W2021778576 @default.
- W1992840257 cites W2032929791 @default.
- W1992840257 cites W2052777747 @default.
- W1992840257 cites W2053230841 @default.
- W1992840257 cites W2084438938 @default.
- W1992840257 cites W2125041154 @default.
- W1992840257 cites W2158203835 @default.
- W1992840257 doi "https://doi.org/10.1080/14786419.2013.871545" @default.
- W1992840257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24422976" @default.
- W1992840257 hasPublicationYear "2014" @default.
- W1992840257 type Work @default.
- W1992840257 sameAs 1992840257 @default.
- W1992840257 citedByCount "20" @default.
- W1992840257 countsByYear W19928402572014 @default.
- W1992840257 countsByYear W19928402572015 @default.
- W1992840257 countsByYear W19928402572016 @default.
- W1992840257 countsByYear W19928402572017 @default.
- W1992840257 countsByYear W19928402572018 @default.
- W1992840257 countsByYear W19928402572019 @default.
- W1992840257 countsByYear W19928402572020 @default.
- W1992840257 countsByYear W19928402572021 @default.
- W1992840257 countsByYear W19928402572022 @default.
- W1992840257 countsByYear W19928402572023 @default.
- W1992840257 crossrefType "journal-article" @default.
- W1992840257 hasAuthorship W1992840257A5036774756 @default.
- W1992840257 hasAuthorship W1992840257A5037263821 @default.
- W1992840257 hasAuthorship W1992840257A5051484473 @default.
- W1992840257 hasAuthorship W1992840257A5083558391 @default.
- W1992840257 hasAuthorship W1992840257A5085349807 @default.
- W1992840257 hasConcept C142724271 @default.
- W1992840257 hasConcept C185592680 @default.
- W1992840257 hasConcept C202751555 @default.
- W1992840257 hasConcept C204787440 @default.
- W1992840257 hasConcept C2776598214 @default.
- W1992840257 hasConcept C2777752497 @default.
- W1992840257 hasConcept C2780069950 @default.
- W1992840257 hasConcept C2780902042 @default.
- W1992840257 hasConcept C55493867 @default.
- W1992840257 hasConcept C556039675 @default.
- W1992840257 hasConcept C71240020 @default.
- W1992840257 hasConcept C71315377 @default.
- W1992840257 hasConcept C71924100 @default.
- W1992840257 hasConceptScore W1992840257C142724271 @default.
- W1992840257 hasConceptScore W1992840257C185592680 @default.
- W1992840257 hasConceptScore W1992840257C202751555 @default.
- W1992840257 hasConceptScore W1992840257C204787440 @default.
- W1992840257 hasConceptScore W1992840257C2776598214 @default.
- W1992840257 hasConceptScore W1992840257C2777752497 @default.
- W1992840257 hasConceptScore W1992840257C2780069950 @default.
- W1992840257 hasConceptScore W1992840257C2780902042 @default.
- W1992840257 hasConceptScore W1992840257C55493867 @default.
- W1992840257 hasConceptScore W1992840257C556039675 @default.
- W1992840257 hasConceptScore W1992840257C71240020 @default.
- W1992840257 hasConceptScore W1992840257C71315377 @default.
- W1992840257 hasConceptScore W1992840257C71924100 @default.
- W1992840257 hasIssue "6" @default.
- W1992840257 hasLocation W19928402571 @default.
- W1992840257 hasLocation W19928402572 @default.
- W1992840257 hasOpenAccess W1992840257 @default.
- W1992840257 hasPrimaryLocation W19928402571 @default.
- W1992840257 hasRelatedWork W2020871254 @default.
- W1992840257 hasRelatedWork W2027682987 @default.
- W1992840257 hasRelatedWork W2052966137 @default.
- W1992840257 hasRelatedWork W2410520226 @default.
- W1992840257 hasRelatedWork W255382357 @default.
- W1992840257 hasRelatedWork W3205682460 @default.
- W1992840257 hasRelatedWork W4238521393 @default.
- W1992840257 hasRelatedWork W4251996317 @default.
- W1992840257 hasRelatedWork W4306842612 @default.
- W1992840257 hasRelatedWork W4323343908 @default.
- W1992840257 hasVolume "28" @default.
- W1992840257 isParatext "false" @default.
- W1992840257 isRetracted "false" @default.
- W1992840257 magId "1992840257" @default.
- W1992840257 workType "article" @default.