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- W1992840710 abstract "This study explored the role of CD40 / CD40 ligand (CD40L) in the induction of a lymphoproliferative response and killing of Cryptococcus neoformans in vitro. In our experimental system, monocytes exposed to C. neoformans were used as antigen-presenting cells (APC) and co-cultured with autologous T cells. The results showed that CD40 / CD40L strongly regulated the blastogenic response of T cells to C. neoformans. The fungus up-regulated CD40 expression on APC. An acapsular strain appeared to be a better inducer than an encapsulated strain. Time course experiments showed optimal regulation of CD40 expression at 48 h of incubation. Blocking the interaction of CD40 on APC with CD40L on T cells using mAb to CD40L resulted in a significant inhibition of IFN-gamma production. The anti-cryptococcal activity of monocytes was greatly influenced by the CD40 / CD40L interaction, and a positive correlation was found between nitric oxide secretion and enhanced killing of C. neoformans. Finally, the CD40 / CD40L interaction was critical for induction of optimal secretion of pro-inflammatory cytokines such as TNF-alpha and IL-1beta. These results indicate an important role for CD40 / CD40L interaction in inducing activation of T cells. Such cell-to-cell contact promotes anti-cryptococcal activity as well as secretion of pro-inflammatory cytokines by monocytes." @default.
- W1992840710 created "2016-06-24" @default.
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- W1992840710 date "2000-05-01" @default.
- W1992840710 modified "2023-10-01" @default.
- W1992840710 title "T lymphocyte and monocyte interaction by CD40 / CD40 ligand facilitates a lymphoproliferative response and killing ofCryptococcus neoformans in vitro" @default.
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- W1992840710 doi "https://doi.org/10.1002/(sici)1521-4141(200005)30:5<1385::aid-immu1385>3.0.co;2-k" @default.
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