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- W1992848596 abstract "The haploid human genome contains approximately 29 million CpGs that exist in a methylated, hydroxymethylated or unmethylated state, collectively referred to as the DNA methylome. The methylation status of cytosines in CpGs and occasionally in non-CpG cytosines influences protein–DNA interactions, gene expression, and chromatin structure and stability. The degree of DNA methylation at particular loci may be heritable transgenerationally and may be altered by environmental exposures and diet, potentially contributing to the development of human diseases. For the vast majority of normal and disease methylomes however, less than 1% of the CpGs have been assessed, revealing the formative stage of methylation mapping techniques. Thus, there is significant discovery potential in new genome-scale platforms applied to methylome mapping, particularly oligonucleotide arrays and the transformative technology of next-generation sequencing. Here, we outline the currently used methylation detection reagents and their application to microarray and sequencing platforms. A comparison of the emerging methods is presented, highlighting their degrees of technical complexity, methylome coverage and precision in resolving methylation. Because there are hundreds of unique methylomes to map within one individual and interindividual variation is likely to be significant, international coordination is essential to standardize methylome platforms and to create a full repository of methylome maps from tissues and unique cell types." @default.
- W1992848596 created "2016-06-24" @default.
- W1992848596 creator A5070998752 @default.
- W1992848596 creator A5088034306 @default.
- W1992848596 creator A5088197113 @default.
- W1992848596 date "2010-02-01" @default.
- W1992848596 modified "2023-10-10" @default.
- W1992848596 title "Genome-scale DNA methylation analysis" @default.
- W1992848596 cites W1484293540 @default.
- W1992848596 cites W1541050437 @default.
- W1992848596 cites W1571666545 @default.
- W1992848596 cites W1859302788 @default.
- W1992848596 cites W1965722916 @default.
- W1992848596 cites W1967841068 @default.
- W1992848596 cites W1971617142 @default.
- W1992848596 cites W1976787939 @default.
- W1992848596 cites W1979273476 @default.
- W1992848596 cites W1979674827 @default.
- W1992848596 cites W1979863914 @default.
- W1992848596 cites W1989296635 @default.
- W1992848596 cites W1989568035 @default.
- W1992848596 cites W1989578834 @default.
- W1992848596 cites W1993645975 @default.
- W1992848596 cites W1995008831 @default.
- W1992848596 cites W2002080579 @default.
- W1992848596 cites W2010043146 @default.
- W1992848596 cites W2012955490 @default.
- W1992848596 cites W2014852291 @default.
- W1992848596 cites W2015612838 @default.
- W1992848596 cites W2017011688 @default.
- W1992848596 cites W2022603493 @default.
- W1992848596 cites W2030352564 @default.
- W1992848596 cites W2043404158 @default.
- W1992848596 cites W2044051799 @default.
- W1992848596 cites W2045646459 @default.
- W1992848596 cites W2046069528 @default.
- W1992848596 cites W2047089740 @default.
- W1992848596 cites W2049174408 @default.
- W1992848596 cites W2050203542 @default.
- W1992848596 cites W2058549086 @default.
- W1992848596 cites W2059099579 @default.
- W1992848596 cites W2059979506 @default.
- W1992848596 cites W206400377 @default.
- W1992848596 cites W2064745720 @default.
- W1992848596 cites W2065949767 @default.
- W1992848596 cites W2067151470 @default.
- W1992848596 cites W2071154937 @default.
- W1992848596 cites W2072139119 @default.
- W1992848596 cites W2073154819 @default.
- W1992848596 cites W2074452993 @default.
- W1992848596 cites W2074765580 @default.
- W1992848596 cites W2076234267 @default.
- W1992848596 cites W2090701958 @default.
- W1992848596 cites W2098362718 @default.
- W1992848596 cites W2100489386 @default.
- W1992848596 cites W2101259235 @default.
- W1992848596 cites W2104429441 @default.
- W1992848596 cites W2106340111 @default.
- W1992848596 cites W2106889224 @default.
- W1992848596 cites W2107337799 @default.
- W1992848596 cites W2107776519 @default.
- W1992848596 cites W2108058966 @default.
- W1992848596 cites W2108664872 @default.
- W1992848596 cites W2111350536 @default.
- W1992848596 cites W2111584908 @default.
- W1992848596 cites W2111594730 @default.
- W1992848596 cites W2112448007 @default.
- W1992848596 cites W2115399760 @default.
- W1992848596 cites W2126404730 @default.
- W1992848596 cites W2128874237 @default.
- W1992848596 cites W2129534676 @default.
- W1992848596 cites W2145909370 @default.
- W1992848596 cites W2148521032 @default.
- W1992848596 cites W2152451432 @default.
- W1992848596 cites W2154929782 @default.
- W1992848596 cites W2158143138 @default.
- W1992848596 cites W2158169867 @default.
- W1992848596 cites W2158668089 @default.
- W1992848596 cites W2161224111 @default.
- W1992848596 cites W2161326542 @default.
- W1992848596 cites W2162344366 @default.
- W1992848596 cites W2164813466 @default.
- W1992848596 cites W2273976338 @default.
- W1992848596 cites W2403241400 @default.
- W1992848596 doi "https://doi.org/10.2217/epi.09.35" @default.
- W1992848596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2907108" @default.
- W1992848596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20657796" @default.
- W1992848596 hasPublicationYear "2010" @default.
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