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• W1992857110 abstract "A role for fibroblast growth factors in stimulating limb and tail regeneration in amphibians has been shown; however, it is unknown whether these growth factors are also involved in the regeneration of the tail of lizard, an amniote model for studies on tissue regeneration. The presence of fibroblast growth factor-1 (FGF1) and -2 (FGF2) in the regenerating tail of the lizard Lampropholis guichenoti has been studied using immunofluorescence labeling. The study reveals that FGF2 is mainly localized in the wound and scaling epidermis, in differentiating muscles, in spinal ganglia, regenerating nerves and spinal cord. FGF1 is also present in the wound and differentiating epidermis, but is detectable at lower levels in the regenerating muscles and spinal cord. FGF1 is present in blastema cells, while FGF2 labeling is relatively low in these cells. Fibroblasts of the forming dermis are rich in FGF1 but not in FGF2. Developing blood vessels label for both FGF1 and FGF2 while the cartilaginous, bone and fat tissues are poorly labeled or unlabeled for FGFs. The present study suggests that most FGFs in the regenerating tail are located in the nervous system, in the epidermis and muscles, and these tissues most likely require these growth factors for their differentiation and growth. The present study suggests that FGFs produced in the regenerating epidermis, spinal cord and nerves can stimulate tail regeneration in lizards." @default.
• W1992857110 created "2016-06-24" @default.
• W1992857110 creator A5033120393 @default.
• W1992857110 creator A5045239901 @default.
• W1992857110 date "2010-09-01" @default.
• W1992857110 modified "2023-09-26" @default.
• W1992857110 title "Immunolocalization of FGF1 and FGF2 in the regenerating tail of the lizard Lampropholis guichenoti: Implications for FGFs as trophic factors in lizard tail regeneration" @default.
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• W1992857110 doi "https://doi.org/10.1016/j.acthis.2009.05.006" @default.
• W1992857110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19589562" @default.
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