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• W1992858154 abstract "The interactions of bio-molecules constitute the key steps of cellular functions. However, in vivo binding properties differ significantly from their in vitro measurements due to the heterogeneity of cellular environments. Here we introduce a coarse-grained model based on rigid-body representation to study how factors such as cellular crowding and membrane confinement affect molecular binding. The macroscopic parameters such as the equilibrium constant and the kinetic rate constant are calibrated by adjusting the microscopic coefficients used in the numerical simulations. By changing these model parameters that are experimentally approachable, we are able to study the kinetic and thermodynamic properties of molecular binding, as well as the effects caused by specific cellular environments. We investigate the volumetric effects of crowded intracellular space on bio-molecular diffusion and diffusion-limited reactions. Furthermore, the binding constants of membrane proteins are currently difficult to measure. We provide quantitative estimations about how the binding of membrane proteins deviates from soluble proteins under different degrees of membrane confinements. The simulation results provide biological insights to the functions of membrane receptors on cell surfaces. Overall, our studies establish a connection between the details of molecular interactions and the heterogeneity of cellular environments." @default.
• W1992858154 created "2016-06-24" @default.
• W1992858154 creator A5005434924 @default.
• W1992858154 creator A5017043628 @default.
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• W1992858154 date "2014-02-07" @default.
• W1992858154 modified "2023-10-16" @default.
• W1992858154 title "A coarse-grained model for the simulations of biomolecular interactions in cellular environments" @default.
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• W1992858154 doi "https://doi.org/10.1063/1.4863992" @default.
• W1992858154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24511927" @default.
• W1992858154 hasPublicationYear "2014" @default.
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