Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992862504> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1992862504 endingPage "570" @default.
- W1992862504 startingPage "565" @default.
- W1992862504 abstract "The tumor necrosis factor-related apoptosis–inducing ligand (TRAIL) and its functional receptors, DR4 and DR5, have been established as promising targets for cancer treatment. Therapeutics targeting TRAIL and its receptors are not only effective in killing many types of tumors, but they also synergize with traditional therapies and show efficacy against tumors that are otherwise resistant to conventional treatments. We describe here the identification and characterization of two human monoclonal antibodies, m921 and m922, that are specific for human DR4. Both antibodies competed with TRAIL for binding to DR4, but only m921 recognized cell surface-associated DR4 and inhibited the growth of ST486 cells. This antibody may have potential for further development as a candidate therapeutic and research tool." @default.
- W1992862504 created "2016-06-24" @default.
- W1992862504 creator A5050128204 @default.
- W1992862504 creator A5064642149 @default.
- W1992862504 creator A5069265733 @default.
- W1992862504 creator A5089862290 @default.
- W1992862504 date "2010-09-01" @default.
- W1992862504 modified "2023-09-24" @default.
- W1992862504 title "Identification and characterization of a novel agonistic anti-DR4 human monoclonal antibody" @default.
- W1992862504 cites W1599806854 @default.
- W1992862504 cites W1964304371 @default.
- W1992862504 cites W1974144614 @default.
- W1992862504 cites W199166898 @default.
- W1992862504 cites W2002507218 @default.
- W1992862504 cites W2023287155 @default.
- W1992862504 cites W2044016592 @default.
- W1992862504 cites W2074106785 @default.
- W1992862504 cites W2078217054 @default.
- W1992862504 cites W2079463756 @default.
- W1992862504 cites W2080156248 @default.
- W1992862504 cites W2090763940 @default.
- W1992862504 cites W2102986716 @default.
- W1992862504 cites W2115978863 @default.
- W1992862504 cites W2136409827 @default.
- W1992862504 cites W2148244207 @default.
- W1992862504 cites W2155567170 @default.
- W1992862504 cites W2169618461 @default.
- W1992862504 doi "https://doi.org/10.4161/mabs.2.5.12570" @default.
- W1992862504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2958577" @default.
- W1992862504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20581445" @default.
- W1992862504 hasPublicationYear "2010" @default.
- W1992862504 type Work @default.
- W1992862504 sameAs 1992862504 @default.
- W1992862504 citedByCount "6" @default.
- W1992862504 countsByYear W19928625042012 @default.
- W1992862504 countsByYear W19928625042015 @default.
- W1992862504 countsByYear W19928625042017 @default.
- W1992862504 countsByYear W19928625042018 @default.
- W1992862504 countsByYear W19928625042019 @default.
- W1992862504 crossrefType "journal-article" @default.
- W1992862504 hasAuthorship W1992862504A5050128204 @default.
- W1992862504 hasAuthorship W1992862504A5064642149 @default.
- W1992862504 hasAuthorship W1992862504A5069265733 @default.
- W1992862504 hasAuthorship W1992862504A5089862290 @default.
- W1992862504 hasBestOaLocation W19928625041 @default.
- W1992862504 hasConcept C118552586 @default.
- W1992862504 hasConcept C159654299 @default.
- W1992862504 hasConcept C170493617 @default.
- W1992862504 hasConcept C187898756 @default.
- W1992862504 hasConcept C203014093 @default.
- W1992862504 hasConcept C2779448149 @default.
- W1992862504 hasConcept C502942594 @default.
- W1992862504 hasConcept C542903549 @default.
- W1992862504 hasConcept C55493867 @default.
- W1992862504 hasConcept C70721500 @default.
- W1992862504 hasConcept C71924100 @default.
- W1992862504 hasConcept C86803240 @default.
- W1992862504 hasConceptScore W1992862504C118552586 @default.
- W1992862504 hasConceptScore W1992862504C159654299 @default.
- W1992862504 hasConceptScore W1992862504C170493617 @default.
- W1992862504 hasConceptScore W1992862504C187898756 @default.
- W1992862504 hasConceptScore W1992862504C203014093 @default.
- W1992862504 hasConceptScore W1992862504C2779448149 @default.
- W1992862504 hasConceptScore W1992862504C502942594 @default.
- W1992862504 hasConceptScore W1992862504C542903549 @default.
- W1992862504 hasConceptScore W1992862504C55493867 @default.
- W1992862504 hasConceptScore W1992862504C70721500 @default.
- W1992862504 hasConceptScore W1992862504C71924100 @default.
- W1992862504 hasConceptScore W1992862504C86803240 @default.
- W1992862504 hasIssue "5" @default.
- W1992862504 hasLocation W19928625041 @default.
- W1992862504 hasLocation W19928625042 @default.
- W1992862504 hasLocation W19928625043 @default.
- W1992862504 hasOpenAccess W1992862504 @default.
- W1992862504 hasPrimaryLocation W19928625041 @default.
- W1992862504 hasRelatedWork W1969822711 @default.
- W1992862504 hasRelatedWork W1999686187 @default.
- W1992862504 hasRelatedWork W2019666956 @default.
- W1992862504 hasRelatedWork W2049834980 @default.
- W1992862504 hasRelatedWork W2063428357 @default.
- W1992862504 hasRelatedWork W2073840950 @default.
- W1992862504 hasRelatedWork W2122584026 @default.
- W1992862504 hasRelatedWork W2340284051 @default.
- W1992862504 hasRelatedWork W2475844698 @default.
- W1992862504 hasRelatedWork W4293213287 @default.
- W1992862504 hasVolume "2" @default.
- W1992862504 isParatext "false" @default.
- W1992862504 isRetracted "false" @default.
- W1992862504 magId "1992862504" @default.
- W1992862504 workType "article" @default.