FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992863880> ?p ?o ?g. }

• W1992863880 endingPage "198" @default.
• W1992863880 startingPage "189" @default.
• W1992863880 abstract "The serotonin (5HT) agonist, m-chlorophenylpiperazine (MCPP), has been used as a challenge agent to assess central 5HT receptor sensitivity in normal subjects and patients with panic disorder, obsessive-compulsive disorder, and major depression. Adrenocorticotropin, cortisol, and prolactin responses to MCPP were among the variables measured. MCPP's usefulness as a probe of 5HT receptors, however, hinges on its 5HT selectivity. To address MCPP's selectivity for 5HT, this study tested whether two different 5HT antagonists, methysergide (4 mg p.o.) and metergoline (4 mg p.o.), could block the hormonal and behavioral effects of MCPP (0.5 mg/kg p.o.) in 10 normal male subjects in comparison to placebo. Both 5HT antagonists abolished the prolactin release to MCPP. Metergoline, the antagonist with the more potent 5HT binding affinity, significantly blocked MCPP's effect on cortisol release as compared to placebo, and methysergide showed a nonsignificant trend to that effect. MCPP alone did not have a significant effect on behavioral variables, perhaps explaining why neither 5HT antagonist affected these measures. The findings from this study suggest that both MCPP-induced prolactin release and cortisol release are indeed 5HT-mediated effects." @default.
• W1992863880 created "2016-06-24" @default.
• W1992863880 creator A5000155732 @default.
• W1992863880 creator A5043620977 @default.
• W1992863880 creator A5047033068 @default.
• W1992863880 creator A5052107665 @default.
• W1992863880 creator A5062319888 @default.
• W1992863880 creator A5062786102 @default.
• W1992863880 date "1990-08-01" @default.
• W1992863880 modified "2023-10-14" @default.
• W1992863880 title "Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects" @default.
• W1992863880 cites W1966438430 @default.
• W1992863880 cites W1970495368 @default.
• W1992863880 cites W1974702488 @default.
• W1992863880 cites W1981443436 @default.
• W1992863880 cites W1982852718 @default.
• W1992863880 cites W1987266590 @default.
• W1992863880 cites W2001271084 @default.
• W1992863880 cites W2003125564 @default.
• W1992863880 cites W2008582348 @default.
• W1992863880 cites W2009821818 @default.
• W1992863880 cites W2013524482 @default.
• W1992863880 cites W2021546946 @default.
• W1992863880 cites W2029338703 @default.
• W1992863880 cites W2030642857 @default.
• W1992863880 cites W2036082219 @default.
• W1992863880 cites W2038361574 @default.
• W1992863880 cites W2048982832 @default.
• W1992863880 cites W2049165791 @default.
• W1992863880 cites W2052474780 @default.
• W1992863880 cites W2054676102 @default.
• W1992863880 cites W2059279128 @default.
• W1992863880 cites W2061685124 @default.
• W1992863880 cites W2065190583 @default.
• W1992863880 cites W2067160581 @default.
• W1992863880 cites W2069947566 @default.
• W1992863880 cites W2070567675 @default.
• W1992863880 cites W2071460225 @default.
• W1992863880 cites W2076127608 @default.
• W1992863880 cites W2088928420 @default.
• W1992863880 cites W2092356890 @default.
• W1992863880 cites W2093688208 @default.
• W1992863880 cites W2155624304 @default.
• W1992863880 cites W2159742394 @default.
• W1992863880 cites W2324939320 @default.
• W1992863880 cites W2345998241 @default.
• W1992863880 cites W2883849285 @default.
• W1992863880 cites W4244667170 @default.
• W1992863880 doi "https://doi.org/10.1016/0165-1781(90)90073-e" @default.
• W1992863880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2243896" @default.
• W1992863880 hasPublicationYear "1990" @default.
• W1992863880 type Work @default.
• W1992863880 sameAs 1992863880 @default.
• W1992863880 citedByCount "49" @default.
• W1992863880 countsByYear W19928638802013 @default.
• W1992863880 countsByYear W19928638802016 @default.
• W1992863880 countsByYear W19928638802022 @default.
• W1992863880 crossrefType "journal-article" @default.
• W1992863880 hasAuthorship W1992863880A5000155732 @default.
• W1992863880 hasAuthorship W1992863880A5043620977 @default.
• W1992863880 hasAuthorship W1992863880A5047033068 @default.
• W1992863880 hasAuthorship W1992863880A5052107665 @default.
• W1992863880 hasAuthorship W1992863880A5062319888 @default.
• W1992863880 hasAuthorship W1992863880A5062786102 @default.
• W1992863880 hasConcept C126322002 @default.
• W1992863880 hasConcept C134018914 @default.
• W1992863880 hasConcept C15744967 @default.
• W1992863880 hasConcept C170493617 @default.
• W1992863880 hasConcept C185592680 @default.
• W1992863880 hasConcept C2775864247 @default.
• W1992863880 hasConcept C2776120623 @default.
• W1992863880 hasConcept C2776885963 @default.
• W1992863880 hasConcept C2777450907 @default.
• W1992863880 hasConcept C2778938600 @default.
• W1992863880 hasConcept C2779064019 @default.
• W1992863880 hasConcept C2781005078 @default.
• W1992863880 hasConcept C2909992730 @default.
• W1992863880 hasConcept C53910766 @default.
• W1992863880 hasConcept C71315377 @default.
• W1992863880 hasConcept C71924100 @default.
• W1992863880 hasConceptScore W1992863880C126322002 @default.
• W1992863880 hasConceptScore W1992863880C134018914 @default.
• W1992863880 hasConceptScore W1992863880C15744967 @default.
• W1992863880 hasConceptScore W1992863880C170493617 @default.
• W1992863880 hasConceptScore W1992863880C185592680 @default.
• W1992863880 hasConceptScore W1992863880C2775864247 @default.
• W1992863880 hasConceptScore W1992863880C2776120623 @default.
• W1992863880 hasConceptScore W1992863880C2776885963 @default.
• W1992863880 hasConceptScore W1992863880C2777450907 @default.
• W1992863880 hasConceptScore W1992863880C2778938600 @default.
• W1992863880 hasConceptScore W1992863880C2779064019 @default.
• W1992863880 hasConceptScore W1992863880C2781005078 @default.
• W1992863880 hasConceptScore W1992863880C2909992730 @default.
• W1992863880 hasConceptScore W1992863880C53910766 @default.
• W1992863880 hasConceptScore W1992863880C71315377 @default.
• W1992863880 hasConceptScore W1992863880C71924100 @default.
• W1992863880 hasIssue "2" @default.
• W1992863880 hasLocation W19928638801 @default.

• next