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- W1992867900 endingPage "1381" @default.
- W1992867900 startingPage "1375" @default.
- W1992867900 abstract "Brain tumor stem cells (BTSCs) stimulate angiogenesis and may also directly contribute to tumor vasculature. The authors review the codependence of BTSCs and the perivascular niche and how this may inform new therapeutic approaches. The brain is a complicated organ with complexity derived from cellular and microenvironmental interactions. Similarly, brain tumor cells actively modify and are regulated by their microenvironment. Brain tumors are highly heterogeneous and frequently show a cellular hierarchy with self-renewing tumorigenic brain tumor stem cells (BTSCs) at the apex. Although BTSCs are distinct from neural stem cells, they share characteristics, including bidirectional interplay with supportive vasculature critical for maintenance of undifferentiated states and survival. BTSCs stimulate angiogenesis through growth factor secretion and are enriched in perivascular niches. Microenvironmental conditions, including hypoxia, drive expression of stem cell genes and proangiogenic factors, further linking cellular hierarchy regulation and instructive stromal elements. BTSCs may also directly contribute to tumor vasculature through plasticity toward an endothelial lineage. Interrogating the codependence of BTSCs and the perivascular niche may directly inform clinical approaches for brain tumor therapy through targeting of highly angiogenic and tumorigenic cellular subsets." @default.
- W1992867900 created "2016-06-24" @default.
- W1992867900 creator A5004589257 @default.
- W1992867900 creator A5021296578 @default.
- W1992867900 creator A5044496405 @default.
- W1992867900 creator A5085537336 @default.
- W1992867900 date "2011-10-26" @default.
- W1992867900 modified "2023-09-25" @default.
- W1992867900 title "Twisted tango: brain tumor neurovascular interactions" @default.
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