Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992884429> ?p ?o ?g. }
- W1992884429 endingPage "119" @default.
- W1992884429 startingPage "108" @default.
- W1992884429 abstract "The positive sense genomes of members of the genus Flavivirus in the family Flaviviridae are ∼ 11 kb in length and have a 5' type I cap but no 3' poly-A. The 3' and 5' terminal regions contain short conserved sequences that are proposed to be repeated remnants of an ancient sequence. However, the functions of most of these conserved sequences have not yet been determined. The terminal regions of the genome also contain multiple conserved RNA structures. Functional data for many of these structures have been obtained. Three sets of complementary 3' and 5' terminal region sequences, some of which are located in conserved RNA structures, interact to form a panhandle structure that is required for initiation of minus strand RNA synthesis with the 5' terminal structure functioning as the promoter. How the switch from the terminal RNA structure base pairing to the long distance RNA-RNA interaction is triggered and regulated is not well understood but evidence suggests involvement of a cell protein binding to three sites on the 3' terminal RNA structures and a cis-acting metastable 3' RNA element in the 3' terminal RNA structure. Cell proteins may also be involved in facilitating exponential replication of nascent genomic RNA within replication vesicles at later times of the infection cycle. Other conserved RNA structures and/or sequences in the 3' and 5' terminal regions have been proposed to regulate genome translation. Additional functions of the 3' and 5' terminal sequences have also been reported." @default.
- W1992884429 created "2016-06-24" @default.
- W1992884429 creator A5006641223 @default.
- W1992884429 creator A5083641020 @default.
- W1992884429 date "2015-08-01" @default.
- W1992884429 modified "2023-10-02" @default.
- W1992884429 title "Functions of the 3′ and 5′ genome RNA regions of members of the genus Flavivirus" @default.
- W1992884429 cites W1488121527 @default.
- W1992884429 cites W1523351143 @default.
- W1992884429 cites W1816614902 @default.
- W1992884429 cites W1942171174 @default.
- W1992884429 cites W1948163770 @default.
- W1992884429 cites W1966601917 @default.
- W1992884429 cites W1967170711 @default.
- W1992884429 cites W1968631180 @default.
- W1992884429 cites W1969303175 @default.
- W1992884429 cites W1971368161 @default.
- W1992884429 cites W1973729131 @default.
- W1992884429 cites W1979016324 @default.
- W1992884429 cites W1980974151 @default.
- W1992884429 cites W1982090618 @default.
- W1992884429 cites W1988402786 @default.
- W1992884429 cites W1989814034 @default.
- W1992884429 cites W1995532797 @default.
- W1992884429 cites W1996999065 @default.
- W1992884429 cites W2002932650 @default.
- W1992884429 cites W2003151628 @default.
- W1992884429 cites W2005510346 @default.
- W1992884429 cites W2006427830 @default.
- W1992884429 cites W2006816262 @default.
- W1992884429 cites W2008070981 @default.
- W1992884429 cites W2008089898 @default.
- W1992884429 cites W2008401094 @default.
- W1992884429 cites W2008437904 @default.
- W1992884429 cites W2010831852 @default.
- W1992884429 cites W2012390132 @default.
- W1992884429 cites W2014438021 @default.
- W1992884429 cites W2018071918 @default.
- W1992884429 cites W2018789255 @default.
- W1992884429 cites W2020962585 @default.
- W1992884429 cites W2021982580 @default.
- W1992884429 cites W2022940439 @default.
- W1992884429 cites W2023858529 @default.
- W1992884429 cites W2026550511 @default.
- W1992884429 cites W2027286159 @default.
- W1992884429 cites W2027598863 @default.
- W1992884429 cites W2028337943 @default.
- W1992884429 cites W2030684239 @default.
- W1992884429 cites W2032753016 @default.
- W1992884429 cites W2034182181 @default.
- W1992884429 cites W2034241642 @default.
- W1992884429 cites W2034751478 @default.
- W1992884429 cites W2034879394 @default.
- W1992884429 cites W2039086039 @default.
- W1992884429 cites W2039711442 @default.
- W1992884429 cites W2039869230 @default.
- W1992884429 cites W2040997589 @default.
- W1992884429 cites W2044104194 @default.
- W1992884429 cites W2047067672 @default.
- W1992884429 cites W2047382488 @default.
- W1992884429 cites W2050843600 @default.
- W1992884429 cites W2053012994 @default.
- W1992884429 cites W2054392394 @default.
- W1992884429 cites W2057093156 @default.
- W1992884429 cites W2060382218 @default.
- W1992884429 cites W2070179005 @default.
- W1992884429 cites W2070573136 @default.
- W1992884429 cites W2071394012 @default.
- W1992884429 cites W2071749695 @default.
- W1992884429 cites W2072134495 @default.
- W1992884429 cites W2076043800 @default.
- W1992884429 cites W2077185255 @default.
- W1992884429 cites W2077587691 @default.
- W1992884429 cites W2084705620 @default.
- W1992884429 cites W2086221905 @default.
- W1992884429 cites W2096949781 @default.
- W1992884429 cites W2103510913 @default.
- W1992884429 cites W2104898502 @default.
- W1992884429 cites W2105186321 @default.
- W1992884429 cites W2105538224 @default.
- W1992884429 cites W2107132989 @default.
- W1992884429 cites W2108615853 @default.
- W1992884429 cites W2108673697 @default.
- W1992884429 cites W2109019244 @default.
- W1992884429 cites W2109274528 @default.
- W1992884429 cites W2109402946 @default.
- W1992884429 cites W2109693158 @default.
- W1992884429 cites W2109902554 @default.
- W1992884429 cites W2111482162 @default.
- W1992884429 cites W2115464691 @default.
- W1992884429 cites W2116988757 @default.
- W1992884429 cites W2117184725 @default.
- W1992884429 cites W2117387018 @default.
- W1992884429 cites W2117660195 @default.
- W1992884429 cites W2119289230 @default.
- W1992884429 cites W2122798331 @default.
- W1992884429 cites W2124008723 @default.
- W1992884429 cites W2125452943 @default.