FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992884654> ?p ?o ?g. }

• W1992884654 abstract "The role of protein kinase C (PKC) on dopamine inhibition of PRL messenger RNA (mRNA) levels was studied in anterior pituitary cells kept in primary culture. PKC was desensitized by long-term exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA). Effectiveness of PKC desensitization was confirmed by the fact that after TPA pretreatment, short-term (1-h) exposure to TPA was no longer able to trigger PRL release. In contrast, the capacity of nonreceptor-mediated secretagogues as depolarization with 48 mM K+ to release the hormone was preserved. Pretreatment with TPA did not affect basal PRL mRNA levels. In contrast, it significantly reduced the dose-dependent inhibition of PRL mRNA induced by 1 nM bromocriptine after a 4-day incubation period. Since dopamine inhibition of PRL release is mediated by several second messager pathways, including cAMP, inositol phosphates, and Ca2+, we investigated whether PKC depletion was able to interact with direct stimulation of these pathways. Pretreatment with PKC suppressed stimulation of PRL mRNA levels induced by either Forskolin (FK) or 8Br-cAMP. In parallel, it reduced basal as well as FK stimulated intracellular cAMP levels. In addition, chronic exposure to TPA completely suppressed PRL mRNA inhibition induced by nifedipine, a dihydropyridine antagonist which blocks voltage-dependent Ca2+ channels. TPA desensitization also affected the action of bromocriptine, FK or nifedipine on PRL release measured under the same conditions. The data indicate that endogenous PKC can interfere with the regulation of PRL gene expression induced by both cAMP and Ca2+ pathways, two second messengers associated with the action of dopamine in lactotroph cells." @default.
• W1992884654 created "2016-06-24" @default.
• W1992884654 creator A5030998265 @default.
• W1992884654 creator A5049773728 @default.
• W1992884654 creator A5078813512 @default.
• W1992884654 creator A5085398262 @default.
• W1992884654 date "1993-02-01" @default.
• W1992884654 modified "2023-09-26" @default.
• W1992884654 title "Protein kinase C regulation of prolactin gene expression in lactotroph cells: involvement in dopamine inhibition." @default.
• W1992884654 cites W1490560449 @default.
• W1992884654 cites W1510793262 @default.
• W1992884654 cites W1528840755 @default.
• W1992884654 cites W1535986268 @default.
• W1992884654 cites W1557272981 @default.
• W1992884654 cites W1571050060 @default.
• W1992884654 cites W1585934860 @default.
• W1992884654 cites W1594758412 @default.
• W1992884654 cites W1716544235 @default.
• W1992884654 cites W1969953025 @default.
• W1992884654 cites W1973135307 @default.
• W1992884654 cites W1979655612 @default.
• W1992884654 cites W1982379411 @default.
• W1992884654 cites W1996626314 @default.
• W1992884654 cites W2010820226 @default.
• W1992884654 cites W2021784043 @default.
• W1992884654 cites W2025196229 @default.
• W1992884654 cites W2029444571 @default.
• W1992884654 cites W2029796924 @default.
• W1992884654 cites W2031422121 @default.
• W1992884654 cites W2047466377 @default.
• W1992884654 cites W2047730381 @default.
• W1992884654 cites W2050338578 @default.
• W1992884654 cites W2051236480 @default.
• W1992884654 cites W2052366220 @default.
• W1992884654 cites W2062532405 @default.
• W1992884654 cites W2064419581 @default.
• W1992884654 cites W2073688909 @default.
• W1992884654 cites W2075253322 @default.
• W1992884654 cites W2076063939 @default.
• W1992884654 cites W2078117339 @default.
• W1992884654 cites W2078840743 @default.
• W1992884654 cites W2086665626 @default.
• W1992884654 cites W2091903287 @default.
• W1992884654 cites W2122088060 @default.
• W1992884654 cites W2134812217 @default.
• W1992884654 cites W2140402339 @default.
• W1992884654 cites W2238505253 @default.
• W1992884654 cites W2266799572 @default.
• W1992884654 cites W2404937024 @default.
• W1992884654 cites W2406431687 @default.
• W1992884654 doi "https://doi.org/10.1210/endo.132.2.7678802" @default.
• W1992884654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7678802" @default.
• W1992884654 hasPublicationYear "1993" @default.
• W1992884654 type Work @default.
• W1992884654 sameAs 1992884654 @default.
• W1992884654 citedByCount "15" @default.
• W1992884654 countsByYear W19928846542015 @default.
• W1992884654 crossrefType "journal-article" @default.
• W1992884654 hasAuthorship W1992884654A5030998265 @default.
• W1992884654 hasAuthorship W1992884654A5049773728 @default.
• W1992884654 hasAuthorship W1992884654A5078813512 @default.
• W1992884654 hasAuthorship W1992884654A5085398262 @default.
• W1992884654 hasConcept C126322002 @default.
• W1992884654 hasConcept C134018914 @default.
• W1992884654 hasConcept C163235415 @default.
• W1992884654 hasConcept C170493617 @default.
• W1992884654 hasConcept C184235292 @default.
• W1992884654 hasConcept C185592680 @default.
• W1992884654 hasConcept C195794163 @default.
• W1992884654 hasConcept C24998067 @default.
• W1992884654 hasConcept C2779064019 @default.
• W1992884654 hasConcept C2779276759 @default.
• W1992884654 hasConcept C513476851 @default.
• W1992884654 hasConcept C62478195 @default.
• W1992884654 hasConcept C71315377 @default.
• W1992884654 hasConcept C71924100 @default.
• W1992884654 hasConcept C86803240 @default.
• W1992884654 hasConcept C95444343 @default.
• W1992884654 hasConcept C97029542 @default.
• W1992884654 hasConceptScore W1992884654C126322002 @default.
• W1992884654 hasConceptScore W1992884654C134018914 @default.
• W1992884654 hasConceptScore W1992884654C163235415 @default.
• W1992884654 hasConceptScore W1992884654C170493617 @default.
• W1992884654 hasConceptScore W1992884654C184235292 @default.
• W1992884654 hasConceptScore W1992884654C185592680 @default.
• W1992884654 hasConceptScore W1992884654C195794163 @default.
• W1992884654 hasConceptScore W1992884654C24998067 @default.
• W1992884654 hasConceptScore W1992884654C2779064019 @default.
• W1992884654 hasConceptScore W1992884654C2779276759 @default.
• W1992884654 hasConceptScore W1992884654C513476851 @default.
• W1992884654 hasConceptScore W1992884654C62478195 @default.
• W1992884654 hasConceptScore W1992884654C71315377 @default.
• W1992884654 hasConceptScore W1992884654C71924100 @default.
• W1992884654 hasConceptScore W1992884654C86803240 @default.
• W1992884654 hasConceptScore W1992884654C95444343 @default.
• W1992884654 hasConceptScore W1992884654C97029542 @default.
• W1992884654 hasLocation W19928846541 @default.
• W1992884654 hasLocation W19928846542 @default.
• W1992884654 hasOpenAccess W1992884654 @default.
• W1992884654 hasPrimaryLocation W19928846541 @default.

• next