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- W1992888686 abstract "Adolescence may be a critical period for drug addiction. Young adolescent male rats have greater locomotor responses than adults after acute low dose cocaine administration. Further, repeated cocaine administration produces as much or more conditioned place preference but reduced locomotor sensitization in adolescents compared to adults. Acute activation of neurons by cocaine induces long-term changes in behavior by activating transcriptional complexes. The purpose of the present study was to correlate cocaine-induced locomotor activity with neuronal activation in subregions of the striatum and cortex by acute cocaine in young adolescent (postnatal (PN) 28) and adult (PN 65) male rats by measuring the induction of the plasticity-associated immediate early genes (IEGs) c-fos and zif268 using in situ hybridization. Animals were treated with saline, low (10 mg/kg), or high (40 mg/kg) dose cocaine in locomotor activity chambers and killed 30 min later. Low dose cocaine induced more locomotor activity and striatal c-fos expression in adolescents than adults whereas high dose cocaine induced more locomotor activity, striatal c-fos, and striatal zif268 expression in adults. Locomotor activity correlated with the expression of both genes in adults but correlated with striatal c-fos only in adolescents. Finally, there was a significant correlation between the expression of c-fos and zif268 in the adult striatum but not in adolescents. Our results suggest that the coordinated expression of transcription factors by cocaine continues to develop during adolescence. The immature regulation of transcription factors by cocaine could explain why adolescents show unique sensitivity to specific long-term behavioral alterations following cocaine treatment." @default.
- W1992888686 created "2016-06-24" @default.
- W1992888686 creator A5016769370 @default.
- W1992888686 creator A5021903894 @default.
- W1992888686 date "2009-04-01" @default.
- W1992888686 modified "2023-09-30" @default.
- W1992888686 title "Maturation of coordinated immediate early gene expression by cocaine during adolescence" @default.
- W1992888686 cites W1544761270 @default.
- W1992888686 cites W1593383161 @default.
- W1992888686 cites W1603788311 @default.
- W1992888686 cites W1917554980 @default.
- W1992888686 cites W1963524546 @default.
- W1992888686 cites W1963811125 @default.
- W1992888686 cites W1965272207 @default.
- W1992888686 cites W1966360491 @default.
- W1992888686 cites W1968605436 @default.
- W1992888686 cites W1970445363 @default.
- W1992888686 cites W1970518640 @default.
- W1992888686 cites W1970669355 @default.
- W1992888686 cites W1971929623 @default.
- W1992888686 cites W1971946857 @default.
- W1992888686 cites W1975431871 @default.
- W1992888686 cites W1979432138 @default.
- W1992888686 cites W1982004851 @default.
- W1992888686 cites W1983869923 @default.
- W1992888686 cites W1985645068 @default.
- W1992888686 cites W1986623115 @default.
- W1992888686 cites W1987190348 @default.
- W1992888686 cites W1988965958 @default.
- W1992888686 cites W1989218079 @default.
- W1992888686 cites W1991603311 @default.
- W1992888686 cites W1992430235 @default.
- W1992888686 cites W1992661478 @default.
- W1992888686 cites W1992853156 @default.
- W1992888686 cites W1993500414 @default.
- W1992888686 cites W1994942770 @default.
- W1992888686 cites W1996885013 @default.
- W1992888686 cites W1997130926 @default.
- W1992888686 cites W1998490449 @default.
- W1992888686 cites W1999948756 @default.
- W1992888686 cites W1999979314 @default.
- W1992888686 cites W2001609826 @default.
- W1992888686 cites W2001891260 @default.
- W1992888686 cites W2003034802 @default.
- W1992888686 cites W2003795799 @default.
- W1992888686 cites W2005657014 @default.
- W1992888686 cites W2005803260 @default.
- W1992888686 cites W2009449932 @default.
- W1992888686 cites W2011444549 @default.
- W1992888686 cites W2011448874 @default.
- W1992888686 cites W2017279410 @default.
- W1992888686 cites W2022247662 @default.
- W1992888686 cites W2023230757 @default.
- W1992888686 cites W2026610324 @default.
- W1992888686 cites W2030939937 @default.
- W1992888686 cites W2033975383 @default.
- W1992888686 cites W2035631704 @default.
- W1992888686 cites W2035771644 @default.
- W1992888686 cites W2036842877 @default.
- W1992888686 cites W2037187885 @default.
- W1992888686 cites W2037195560 @default.
- W1992888686 cites W2043065683 @default.
- W1992888686 cites W2047313211 @default.
- W1992888686 cites W2048280165 @default.
- W1992888686 cites W2048456023 @default.
- W1992888686 cites W2049264581 @default.
- W1992888686 cites W2049900893 @default.
- W1992888686 cites W2050421671 @default.
- W1992888686 cites W2053699396 @default.
- W1992888686 cites W2054090847 @default.
- W1992888686 cites W2054965221 @default.
- W1992888686 cites W2055304866 @default.
- W1992888686 cites W2057377674 @default.
- W1992888686 cites W2062031160 @default.
- W1992888686 cites W2064474940 @default.
- W1992888686 cites W2071513634 @default.
- W1992888686 cites W2071663070 @default.
- W1992888686 cites W2071770303 @default.
- W1992888686 cites W2073278605 @default.
- W1992888686 cites W2073482098 @default.
- W1992888686 cites W2078085518 @default.
- W1992888686 cites W2082308885 @default.
- W1992888686 cites W2083643445 @default.
- W1992888686 cites W2084114882 @default.
- W1992888686 cites W2087683500 @default.
- W1992888686 cites W2089775599 @default.
- W1992888686 cites W2091667170 @default.
- W1992888686 cites W2093622479 @default.
- W1992888686 cites W2097872145 @default.
- W1992888686 cites W2097919380 @default.
- W1992888686 cites W2102773298 @default.
- W1992888686 cites W2103145224 @default.
- W1992888686 cites W2106719141 @default.
- W1992888686 cites W2110845857 @default.
- W1992888686 cites W2135412747 @default.
- W1992888686 cites W2135720249 @default.
- W1992888686 cites W2136468829 @default.
- W1992888686 cites W2136911105 @default.