FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992893247> ?p ?o ?g. }

• W1992893247 endingPage "1145" @default.
• W1992893247 startingPage "1140" @default.
• W1992893247 abstract "Sepsis and systemic inflammatory response syndrome (SIRS) are major causes of morbidity and mortality after cardiopulmonary bypass. Attempts to suppress proinflammatory mediators have failed to improve outcomes in sepsis or in patients undergoing cardiopulmonary bypass. Recent work in adult patients has suggested that the balance between pro- and anti-inflammatory mediators is more important than the level of proinflammatory response alone. This balance may be reflected by the expression of monocyte human lymphocyte antigen (HLA)-DR, with low concentrations indicating an excess of anti-inflammatory stimuli and relative immunodeficiency. We investigated the relationship between monocyte HLA-DR expression and the subsequent development of sepsis/SIRS in children undergoing cardiopulmonary bypass.A prospective, observational, clinical study.A tertiary pediatric cardiac center.Eighty-two infants and children undergoing elective cardiac surgery between March and December 1999.Monocyte HLA-DR expression was assessed before and after surgery and was found to be related to the length of hospital stay and the development of complications including sepsis/SIRS. The inflammatory insult of cardiopulmonary bypass decreased monocyte HLA-DR expression in all children. Lowest concentrations were seen within 72 hrs of surgery and were significantly lower in cases that subsequently required prolonged intensive care support (p <.0001, Mann-Whitney). HLA-DR expression on <60% of circulating monocytes was associated with a greatly increased risk of later (minimum 4 days) development of sepsis/SIRS (odds ratio, 12.9; 95% confidence interval, 3.4-47.5). Low HLA-DR was an independent predictor for the development of sepsis/SIRS after correction for age, bypass time, complexity of surgery, Paediatric Index of Mortality, and surgeon on multiple logistic regression analysis.Patients with decreased HLA-DR in the early postoperative period represent a subpopulation at greatly increased risk of later sepsis/SIRS. Such patients may benefit from strategies aimed to reduce this risk." @default.
• W1992893247 created "2016-06-24" @default.
• W1992893247 creator A5004704601 @default.
• W1992893247 creator A5005617480 @default.
• W1992893247 creator A5023231994 @default.
• W1992893247 creator A5025217856 @default.
• W1992893247 creator A5035342394 @default.
• W1992893247 creator A5047227254 @default.
• W1992893247 creator A5050377625 @default.
• W1992893247 date "2002-05-01" @default.
• W1992893247 modified "2023-10-10" @default.
• W1992893247 title "Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care*" @default.
• W1992893247 cites W1965199806 @default.
• W1992893247 cites W1972757665 @default.
• W1992893247 cites W1975529559 @default.
• W1992893247 cites W1984666117 @default.
• W1992893247 cites W1986014873 @default.
• W1992893247 cites W1996291400 @default.
• W1992893247 cites W1997045840 @default.
• W1992893247 cites W2012589576 @default.
• W1992893247 cites W2019043807 @default.
• W1992893247 cites W2031039655 @default.
• W1992893247 cites W2035959902 @default.
• W1992893247 cites W2042474497 @default.
• W1992893247 cites W2047632277 @default.
• W1992893247 cites W2061735986 @default.
• W1992893247 cites W2065322500 @default.
• W1992893247 cites W2074389001 @default.
• W1992893247 cites W2085439684 @default.
• W1992893247 cites W2086083704 @default.
• W1992893247 cites W2093287784 @default.
• W1992893247 cites W2099997928 @default.
• W1992893247 cites W2106530602 @default.
• W1992893247 cites W2109765855 @default.
• W1992893247 cites W2110720742 @default.
• W1992893247 cites W2123599545 @default.
• W1992893247 cites W2139963011 @default.
• W1992893247 cites W2144986524 @default.
• W1992893247 cites W2150674484 @default.
• W1992893247 cites W2157825442 @default.
• W1992893247 cites W2167233342 @default.
• W1992893247 cites W2599527603 @default.
• W1992893247 doi "https://doi.org/10.1097/00003246-200205000-00031" @default.
• W1992893247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12006816" @default.
• W1992893247 hasPublicationYear "2002" @default.
• W1992893247 type Work @default.
• W1992893247 sameAs 1992893247 @default.
• W1992893247 citedByCount "121" @default.
• W1992893247 countsByYear W19928932472012 @default.
• W1992893247 countsByYear W19928932472013 @default.
• W1992893247 countsByYear W19928932472014 @default.
• W1992893247 countsByYear W19928932472015 @default.
• W1992893247 countsByYear W19928932472016 @default.
• W1992893247 countsByYear W19928932472017 @default.
• W1992893247 countsByYear W19928932472018 @default.
• W1992893247 countsByYear W19928932472019 @default.
• W1992893247 countsByYear W19928932472020 @default.
• W1992893247 countsByYear W19928932472021 @default.
• W1992893247 countsByYear W19928932472022 @default.
• W1992893247 countsByYear W19928932472023 @default.
• W1992893247 crossrefType "journal-article" @default.
• W1992893247 hasAuthorship W1992893247A5004704601 @default.
• W1992893247 hasAuthorship W1992893247A5005617480 @default.
• W1992893247 hasAuthorship W1992893247A5023231994 @default.
• W1992893247 hasAuthorship W1992893247A5025217856 @default.
• W1992893247 hasAuthorship W1992893247A5035342394 @default.
• W1992893247 hasAuthorship W1992893247A5047227254 @default.
• W1992893247 hasAuthorship W1992893247A5050377625 @default.
• W1992893247 hasConcept C126322002 @default.
• W1992893247 hasConcept C156957248 @default.
• W1992893247 hasConcept C164027704 @default.
• W1992893247 hasConcept C177713679 @default.
• W1992893247 hasConcept C203014093 @default.
• W1992893247 hasConcept C2776252253 @default.
• W1992893247 hasConcept C2776914184 @default.
• W1992893247 hasConcept C2778384902 @default.
• W1992893247 hasConcept C2778789114 @default.
• W1992893247 hasConcept C2778881276 @default.
• W1992893247 hasConcept C2781090800 @default.
• W1992893247 hasConcept C2781184567 @default.
• W1992893247 hasConcept C2987404301 @default.
• W1992893247 hasConcept C42219234 @default.
• W1992893247 hasConcept C71924100 @default.
• W1992893247 hasConceptScore W1992893247C126322002 @default.
• W1992893247 hasConceptScore W1992893247C156957248 @default.
• W1992893247 hasConceptScore W1992893247C164027704 @default.
• W1992893247 hasConceptScore W1992893247C177713679 @default.
• W1992893247 hasConceptScore W1992893247C203014093 @default.
• W1992893247 hasConceptScore W1992893247C2776252253 @default.
• W1992893247 hasConceptScore W1992893247C2776914184 @default.
• W1992893247 hasConceptScore W1992893247C2778384902 @default.
• W1992893247 hasConceptScore W1992893247C2778789114 @default.
• W1992893247 hasConceptScore W1992893247C2778881276 @default.
• W1992893247 hasConceptScore W1992893247C2781090800 @default.
• W1992893247 hasConceptScore W1992893247C2781184567 @default.
• W1992893247 hasConceptScore W1992893247C2987404301 @default.
• W1992893247 hasConceptScore W1992893247C42219234 @default.
• W1992893247 hasConceptScore W1992893247C71924100 @default.

• next