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- W1992906130 abstract "Prion proteins are known to misfold into a range of different aggregated forms, showing different phenotypic and pathological states. Understanding strain specificities is an important problem in the field of prion disease. Little is known about which PrPSc structural properties and molecular mechanisms determine prion replication, disease progression and strain phenotype. The aim of this work is to investigate, through a mathematical model, how the structural stability of different aggregated forms can influence the kinetics of prion replication. The model-based results suggest that prion strains with different conformational stability undergoing in vivo replication are characterizable in primis by means of different rates of breakage. A further role seems to be played by the aggregation rate (i.e. the rate at which a prion fibril grows). The kinetic variability introduced in the model by these two parameters allows us to reproduce the different characteristic features of the various strains (e.g., fibrils' mean length) and is coherent with all experimental observations concerning strain-specific behavior." @default.
- W1992906130 created "2016-06-24" @default.
- W1992906130 creator A5006285239 @default.
- W1992906130 creator A5048112243 @default.
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- W1992906130 date "2009-07-03" @default.
- W1992906130 modified "2023-09-30" @default.
- W1992906130 title "Investigating the Conformational Stability of Prion Strains through a Kinetic Replication Model" @default.
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- W1992906130 doi "https://doi.org/10.1371/journal.pcbi.1000420" @default.
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