FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992910185> ?p ?o ?g. }

• W1992910185 abstract "We have measured the activities of two androgen metabolizing enzymes in tissue obtained from thirty-nine patients with carcinoma of the prostate (CaP). The enzyme activities were correlated to the histological differentiation of the tumours based on the Gleason Score and also compared to the activities measured in fourteen age matched patients with nodular prostatic hyperplasia (BPH). Although the mean values for the 5 alpha-reductase in CaP (9.29 +/- 1.47 pmol/mg protein/30 min) were found to be significantly lower than the corresponding values in BPH (16.26 +/- 3.04 pmol/mg protein/30 min) (P less than 0.05), there were nonetheless significant differences within the cancer group and these were totally dependent on the degree of differentiation of the tumour. A progressively suppressed enzyme activity was measured as the carcinomatous tissue became more anaplastic. No correlation was, however, observed between tumour bulk which was also estimated histologically and 5 alpha-reductase, indicating that the activity of this enzyme is purely a function of the histological grade of the cancer and as such 5 alpha-reductase could be used as a biochemical marker for tumour differentiation. We also measured the 3 alpha (beta)-hydroxysteroid dehydrogenase activities in cancer of the prostate but our findings indicated no significant differences between the various stages of the cancer. Furthermore we were unable to correlate the activities of this enzyme with that of the 5 alpha-reductase. Nonetheless two interesting patterns relating to the 3 alpha (beta)-hydroxysteroid dehydrogenase emerged.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W1992910185 created "2016-06-24" @default.
• W1992910185 creator A5027515987 @default.
• W1992910185 creator A5045186401 @default.
• W1992910185 creator A5063529170 @default.
• W1992910185 creator A5077424387 @default.
• W1992910185 date "1985-10-01" @default.
• W1992910185 modified "2023-09-27" @default.
• W1992910185 title "5α-REDUCTASE ACTIVITY IN HUMAN PROSTATE CANCER IS RELATED TO THE HISTOLOGICAL DIFFERENTIATION OF THE TUMOUR" @default.
• W1992910185 cites W1963806361 @default.
• W1992910185 cites W1985282899 @default.
• W1992910185 cites W1995314302 @default.
• W1992910185 cites W1995647489 @default.
• W1992910185 cites W1996957404 @default.
• W1992910185 cites W1997534477 @default.
• W1992910185 cites W2000483762 @default.
• W1992910185 cites W2014326024 @default.
• W1992910185 cites W2019544029 @default.
• W1992910185 cites W2053135991 @default.
• W1992910185 cites W2059966482 @default.
• W1992910185 cites W2068633040 @default.
• W1992910185 cites W2071113538 @default.
• W1992910185 cites W2079586839 @default.
• W1992910185 cites W2103798082 @default.
• W1992910185 cites W2128635872 @default.
• W1992910185 cites W2135389629 @default.
• W1992910185 cites W2419610088 @default.
• W1992910185 cites W2462652496 @default.
• W1992910185 doi "https://doi.org/10.1111/j.1365-2265.1985.tb01101.x" @default.
• W1992910185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3864568" @default.
• W1992910185 hasPublicationYear "1985" @default.
• W1992910185 type Work @default.
• W1992910185 sameAs 1992910185 @default.
• W1992910185 citedByCount "26" @default.
• W1992910185 countsByYear W19929101852013 @default.
• W1992910185 crossrefType "journal-article" @default.
• W1992910185 hasAuthorship W1992910185A5027515987 @default.
• W1992910185 hasAuthorship W1992910185A5045186401 @default.
• W1992910185 hasAuthorship W1992910185A5063529170 @default.
• W1992910185 hasAuthorship W1992910185A5077424387 @default.
• W1992910185 hasConcept C121608353 @default.
• W1992910185 hasConcept C126322002 @default.
• W1992910185 hasConcept C134018914 @default.
• W1992910185 hasConcept C134651460 @default.
• W1992910185 hasConcept C141071460 @default.
• W1992910185 hasConcept C181199279 @default.
• W1992910185 hasConcept C2775874879 @default.
• W1992910185 hasConcept C2775944032 @default.
• W1992910185 hasConcept C2776235491 @default.
• W1992910185 hasConcept C2776317432 @default.
• W1992910185 hasConcept C2777546739 @default.
• W1992910185 hasConcept C2777562237 @default.
• W1992910185 hasConcept C2777911890 @default.
• W1992910185 hasConcept C2780192828 @default.
• W1992910185 hasConcept C28212737 @default.
• W1992910185 hasConcept C2910366748 @default.
• W1992910185 hasConcept C49453240 @default.
• W1992910185 hasConcept C55493867 @default.
• W1992910185 hasConcept C64943373 @default.
• W1992910185 hasConcept C71315377 @default.
• W1992910185 hasConcept C71924100 @default.
• W1992910185 hasConcept C86803240 @default.
• W1992910185 hasConceptScore W1992910185C121608353 @default.
• W1992910185 hasConceptScore W1992910185C126322002 @default.
• W1992910185 hasConceptScore W1992910185C134018914 @default.
• W1992910185 hasConceptScore W1992910185C134651460 @default.
• W1992910185 hasConceptScore W1992910185C141071460 @default.
• W1992910185 hasConceptScore W1992910185C181199279 @default.
• W1992910185 hasConceptScore W1992910185C2775874879 @default.
• W1992910185 hasConceptScore W1992910185C2775944032 @default.
• W1992910185 hasConceptScore W1992910185C2776235491 @default.
• W1992910185 hasConceptScore W1992910185C2776317432 @default.
• W1992910185 hasConceptScore W1992910185C2777546739 @default.
• W1992910185 hasConceptScore W1992910185C2777562237 @default.
• W1992910185 hasConceptScore W1992910185C2777911890 @default.
• W1992910185 hasConceptScore W1992910185C2780192828 @default.
• W1992910185 hasConceptScore W1992910185C28212737 @default.
• W1992910185 hasConceptScore W1992910185C2910366748 @default.
• W1992910185 hasConceptScore W1992910185C49453240 @default.
• W1992910185 hasConceptScore W1992910185C55493867 @default.
• W1992910185 hasConceptScore W1992910185C64943373 @default.
• W1992910185 hasConceptScore W1992910185C71315377 @default.
• W1992910185 hasConceptScore W1992910185C71924100 @default.
• W1992910185 hasConceptScore W1992910185C86803240 @default.
• W1992910185 hasLocation W19929101851 @default.
• W1992910185 hasLocation W19929101852 @default.
• W1992910185 hasOpenAccess W1992910185 @default.
• W1992910185 hasPrimaryLocation W19929101851 @default.
• W1992910185 hasRelatedWork W1978436374 @default.
• W1992910185 hasRelatedWork W1988349451 @default.
• W1992910185 hasRelatedWork W1992423160 @default.
• W1992910185 hasRelatedWork W1992910185 @default.
• W1992910185 hasRelatedWork W2018931547 @default.
• W1992910185 hasRelatedWork W2044613489 @default.
• W1992910185 hasRelatedWork W2061639816 @default.
• W1992910185 hasRelatedWork W2082130579 @default.
• W1992910185 hasRelatedWork W2087652180 @default.
• W1992910185 hasRelatedWork W2119049688 @default.
• W1992910185 isParatext "false" @default.
• W1992910185 isRetracted "false" @default.

• next