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• W1992912014 abstract "<h2>Abstract</h2> A cell line named ROS-50 (Rotterdam suspension cell line no. 50) has been established from peripheral blood of a 69-year-old male with acute lymphoblastic leukemia (FAB type L3). Among the aberrations, cytogenetic analysis showed the presence of 14q+, 18q−, and two 8q− marker chromosomes. With fluorescence in situ hybridization (FISH) we characterized the chromosomal translocations, t(8;14) and t(14;18), in which the same chromosome 14 is involved. PCR analysis demonstrated the presence of an IGH-BCL2 rearrangement with a breakpoint in the minor cluster region (mcr) confirming the t(14;18) characteristic for follicular lymphoma. Additional studies showed high expression of BCL2 protein, an early B-cell immunophenotype, and an unusual pattern of IGH gene rearrangement." @default.
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• W1992912014 date "1994-06-01" @default.
• W1992912014 modified "2023-09-23" @default.
• W1992912014 title "A new B-cell line showing a complex translocation (8;14;18) and BCL2 rearrangement" @default.
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• W1992912014 doi "https://doi.org/10.1016/0165-4608(94)90003-5" @default.
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