Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992913595> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1992913595 endingPage "1178" @default.
- W1992913595 startingPage "1175" @default.
- W1992913595 abstract "An immunoassay based on monoclonal antibodies with specificity for the three major isoenzymes of alkaline phosphatase (ALP) has been used in second-trimester prenatal diagnosis of cystic fibrosis (CF). 140 pregnancies with a 1-in-4 risk of CF were assessed prospectively, and outcomes are reported for 100 of these. In 9 cases the diagnosis could not be confirmed or excluded, in 65 cases the infant was normal, and in 15 the infant had CF. In the remaining 11 cases, in which the pregnancy was terminated, the diagnosis of CF was confirmed in the abortus by measurement of albumin and protease levels in meconium scraped from the fetal ileum. Of the 26 cases of CF in the prospective series, 23 (88%) had values of intestinal ALP below half the median value for the corresponding week of gestation. Among those with normal outcomes 3 of 65 (4.6%) were below half-median. When prospective and retrospective data are summed the sensitivity of the test was 91% (39 of 43) and the false-positive rate 6% (5 of 81). This is probably an acceptable form of prenatal diagnosis of CF for the high-risk mother." @default.
- W1992913595 created "2016-06-24" @default.
- W1992913595 creator A5002454380 @default.
- W1992913595 creator A5031090783 @default.
- W1992913595 creator A5045835301 @default.
- W1992913595 creator A5068243310 @default.
- W1992913595 date "1985-05-01" @default.
- W1992913595 modified "2023-09-27" @default.
- W1992913595 title "PROSPECTIVE PRENATAL DIAGNOSIS OF CYSTIC FIBROSIS" @default.
- W1992913595 cites W1541541103 @default.
- W1992913595 cites W1964661614 @default.
- W1992913595 cites W1970934137 @default.
- W1992913595 cites W2010445074 @default.
- W1992913595 cites W2022736108 @default.
- W1992913595 cites W2046887733 @default.
- W1992913595 cites W2060201266 @default.
- W1992913595 cites W2084404273 @default.
- W1992913595 cites W2109117589 @default.
- W1992913595 cites W2132831552 @default.
- W1992913595 cites W2140190827 @default.
- W1992913595 cites W2411604271 @default.
- W1992913595 cites W4230786705 @default.
- W1992913595 cites W4247676307 @default.
- W1992913595 doi "https://doi.org/10.1016/s0140-6736(85)92860-0" @default.
- W1992913595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2860384" @default.
- W1992913595 hasPublicationYear "1985" @default.
- W1992913595 type Work @default.
- W1992913595 sameAs 1992913595 @default.
- W1992913595 citedByCount "59" @default.
- W1992913595 countsByYear W19929135952014 @default.
- W1992913595 crossrefType "journal-article" @default.
- W1992913595 hasAuthorship W1992913595A5002454380 @default.
- W1992913595 hasAuthorship W1992913595A5031090783 @default.
- W1992913595 hasAuthorship W1992913595A5045835301 @default.
- W1992913595 hasAuthorship W1992913595A5068243310 @default.
- W1992913595 hasConcept C126322002 @default.
- W1992913595 hasConcept C131872663 @default.
- W1992913595 hasConcept C172680121 @default.
- W1992913595 hasConcept C188816634 @default.
- W1992913595 hasConcept C2776938444 @default.
- W1992913595 hasConcept C2778258057 @default.
- W1992913595 hasConcept C2779234561 @default.
- W1992913595 hasConcept C2780985857 @default.
- W1992913595 hasConcept C46973012 @default.
- W1992913595 hasConcept C54355233 @default.
- W1992913595 hasConcept C71924100 @default.
- W1992913595 hasConcept C86803240 @default.
- W1992913595 hasConcept C90924648 @default.
- W1992913595 hasConceptScore W1992913595C126322002 @default.
- W1992913595 hasConceptScore W1992913595C131872663 @default.
- W1992913595 hasConceptScore W1992913595C172680121 @default.
- W1992913595 hasConceptScore W1992913595C188816634 @default.
- W1992913595 hasConceptScore W1992913595C2776938444 @default.
- W1992913595 hasConceptScore W1992913595C2778258057 @default.
- W1992913595 hasConceptScore W1992913595C2779234561 @default.
- W1992913595 hasConceptScore W1992913595C2780985857 @default.
- W1992913595 hasConceptScore W1992913595C46973012 @default.
- W1992913595 hasConceptScore W1992913595C54355233 @default.
- W1992913595 hasConceptScore W1992913595C71924100 @default.
- W1992913595 hasConceptScore W1992913595C86803240 @default.
- W1992913595 hasConceptScore W1992913595C90924648 @default.
- W1992913595 hasIssue "8439" @default.
- W1992913595 hasLocation W19929135951 @default.
- W1992913595 hasLocation W19929135952 @default.
- W1992913595 hasOpenAccess W1992913595 @default.
- W1992913595 hasPrimaryLocation W19929135951 @default.
- W1992913595 hasRelatedWork W1993795923 @default.
- W1992913595 hasRelatedWork W2039466440 @default.
- W1992913595 hasRelatedWork W2056752164 @default.
- W1992913595 hasRelatedWork W2093112264 @default.
- W1992913595 hasRelatedWork W2163638983 @default.
- W1992913595 hasRelatedWork W2329009029 @default.
- W1992913595 hasRelatedWork W2368136628 @default.
- W1992913595 hasRelatedWork W2756654690 @default.
- W1992913595 hasRelatedWork W28170546 @default.
- W1992913595 hasRelatedWork W2309276520 @default.
- W1992913595 hasVolume "325" @default.
- W1992913595 isParatext "false" @default.
- W1992913595 isRetracted "false" @default.
- W1992913595 magId "1992913595" @default.
- W1992913595 workType "article" @default.