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• W1992925516 abstract "Abstract The development of biological electron-probe X-ray microanalysis is traced from the late 1950s and now, and present capabilities are assessed with reference to various types of specimen (bulk specimen, thin or ultrathin section, etc.). Initially the instrumental sensitiveties were adequate for little more than studies of calcium in mineralized tissues and studies of abnormalities, and there were no procedures for quantitative analysis. After great improvement in sensitivity (an improvement in minimum detectable mass from about 10-14 to about 10-19 g of an element), and the development of cryopreparation to preserve elemental distributions on a fine scale, it is possible now even to determine the concentrations of the major diffusible electrolyte elements within cells, subcellular organelles and compartments and within extracellular spaces." @default.
• W1992925516 created "2016-06-24" @default.
• W1992925516 creator A5059544114 @default.
• W1992925516 date "1986-01-01" @default.
• W1992925516 modified "2023-09-24" @default.
• W1992925516 title "The history and the current status of biological electron-probe X-ray microanalysis" @default.
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• W1992925516 doi "https://doi.org/10.1016/0739-6260(86)90039-0" @default.
• W1992925516 hasPublicationYear "1986" @default.
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