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• W1992933456 abstract "Consistent with the epileptogenic and deleterious effects of the potent neurotoxin kainate, the activation of kainate receptors reduces the synaptic inhibition induced by the amino acid gamma-aminobutyric acid (GABA). Extrapolating from these data led to the conclusion that kainate receptors are located presynaptically. However, kainate directly depolarizes the inhibitory interneurons, causing them to fire repeatedly. This effect might indirectly decrease the size of inhibitory postsynaptic currents recorded from pyramidal cells and places in doubt the presynaptic location for kainate receptors. Here we show that both effects, membrane depolarization and the reduction of inhibitory potentials, can be dissociated by several means, particularly by the natural agonist of kainate receptors, glutamate. Indeed, when applied at low concentrations, glutamate inhibited GABA release without affecting the firing rate of GABA interneurons. These results indicate that CA1 interneurons contain two populations of kainate receptors, each with different agonist sensitivity and coupled to distinct signaling pathways." @default.
• W1992933456 created "2016-06-24" @default.
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• W1992933456 date "2000-02-01" @default.
• W1992933456 modified "2023-10-01" @default.
• W1992933456 title "Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons" @default.
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• W1992933456 doi "https://doi.org/10.1073/pnas.97.3.1293" @default.
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