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- W1992942499 abstract "<h3>Objective</h3> To compare prostacyclin with an analogue, iloprost, in treatment of severe pulmonary hypertension. <h3>Patients</h3> Eight patients with severe pulmonary hypertension: primary in five, thromboembolic pulmonary hypertension in three. <h3>Methods</h3> All patients underwent right heart catheterisation. Mean (SEM) right atrial pressure was 9.9 (2.2) mm Hg, mean pulmonary artery pressure 67.4 (3.0) mm Hg, cardiac index 1.75 (0.13) l/min/m<sup>2</sup> and mixed venous oxygen saturation 59.1(3.1)%. Continuous intravenous epoprostenol (prostacyclin, PGI<sub>2</sub>) or iloprost was given for phase I (three to six weeks); the patients were then crossed over to receive the alternate drug in an equivalent phase II. <h3>Main outcome measures</h3> Exercise tolerance was measured at baseline and at the end of phase I and II with a 12 minute walk; distance covered, rest period, percentage drop in arterial oxygen saturation (ΔSao<sub>2</sub>%) and percentage rise in heart rate (ΔHR%). <h3>Results</h3> Walking distance covered rose from (mean (SEM)) 407.5 (73) to 591 (46) m with PGI<sub>2</sub>(p = 0.004) and to 602.5 (60) m while on iloprost (p = 0.008). Rest period decreased from 192 (73) seconds at baseline to 16 (16) seconds with PGI<sub>2</sub> (p = 0.01) and to 58 (34) seconds with iloprost (p = 0.008). ΔHR% was 37.5(6)% at baseline, 35(3)% on PGI<sub>2</sub>, and 24(6)% on iloprost (p = 0.04). <h3>Conclusions</h3> Both intravenous PGI<sub>2</sub> and iloprost caused significant improvement in exercise tolerance. Iloprost offers an alternative to PGI<sub>2</sub> treatment of severe pulmonary hypertension." @default.
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- W1992942499 title "Treatment of pulmonary hypertension with the continuous infusion of a prostacyclin analogue, iloprost" @default.
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- W1992942499 doi "https://doi.org/10.1136/hrt.79.2.175" @default.
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