Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992946670> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1992946670 endingPage "95" @default.
- W1992946670 startingPage "95" @default.
- W1992946670 abstract "Background: The inflammatory disease is associated with chronic pain and hypersensitivity to noxious stimuli in form of hyperalgesia. Transient receptor potential vanilloid type-1 (TRPV1) activated by various inflammatory mediators; plays a key role in occurrence of hyperalgesia. Piperine is the primary pungent alkaloid of Piper nigrum. Piperine has common binding site with capsaicin (TRPV1 agonist) on TRPV1 and it has more efficacy for activation of TRPV1 than capsaicin. Objective: The purpose of the study was to investigate the role of TRPV1 in piperine induced hyperalgesia in diabetic mice. Methods: Diabetes mellitus was induced in mice using streptozotocin (STZ). Nociception was measured by three types of thermal nociceptive tests (Hot plate method, radient heat tail-flick method and tail immersion test). Pilot study (using 2.5, 5, 10 and 50 mg kg-1 piperine, i.p.) was carried out and 5 mg kg-1 piperine is used as optimum dose for further study. Capsaicin, capsazepine and piperine were administered to their respected groups and nociceptive threshold was noted on day 4, 7 and 10 in all groups. Results: Piperine showed a significant decrease in nociceptive threshold as compared to diabetic control group, while there was a significant increase in reaction time, tail flick latency and tail withdrawal latency, in the animals pre-treated with capsazepine before piperine administration as compare to only piperine treated diabetic group. Conclusion: Activation of TRPV1 might be one of the possible mechanisms of Piperine induced hyperalgesia. Keywords : Capsaicin, Capsazepine, Hyperalgesia, Nociceptive Threshold, Piperine, TRPV1." @default.
- W1992946670 created "2016-06-24" @default.
- W1992946670 creator A5017373674 @default.
- W1992946670 creator A5080410165 @default.
- W1992946670 creator A5090950794 @default.
- W1992946670 date "2014-10-17" @default.
- W1992946670 modified "2023-10-18" @default.
- W1992946670 title "Role of trpv1 (transient receptor potential v1 channel) in piperine induced hyperalgesia: a preliminary study" @default.
- W1992946670 cites W1511198581 @default.
- W1992946670 cites W1923918181 @default.
- W1992946670 cites W1970184110 @default.
- W1992946670 cites W1976236901 @default.
- W1992946670 cites W1978097698 @default.
- W1992946670 cites W1981812286 @default.
- W1992946670 cites W1987192367 @default.
- W1992946670 cites W1990089345 @default.
- W1992946670 cites W2006132476 @default.
- W1992946670 cites W2017492367 @default.
- W1992946670 cites W2023486326 @default.
- W1992946670 cites W2033223894 @default.
- W1992946670 cites W2050781058 @default.
- W1992946670 cites W2053864414 @default.
- W1992946670 cites W2054024143 @default.
- W1992946670 cites W2058032884 @default.
- W1992946670 cites W2079312738 @default.
- W1992946670 cites W2090617423 @default.
- W1992946670 cites W2094898453 @default.
- W1992946670 cites W2096419853 @default.
- W1992946670 cites W2106207830 @default.
- W1992946670 cites W2107705149 @default.
- W1992946670 cites W2116428092 @default.
- W1992946670 cites W2128005614 @default.
- W1992946670 cites W2130600650 @default.
- W1992946670 cites W2134742719 @default.
- W1992946670 cites W2154843401 @default.
- W1992946670 cites W2165489866 @default.
- W1992946670 cites W2171764139 @default.
- W1992946670 cites W2206043426 @default.
- W1992946670 cites W314108637 @default.
- W1992946670 doi "https://doi.org/10.14419/ijpt.v2i2.3269" @default.
- W1992946670 hasPublicationYear "2014" @default.
- W1992946670 type Work @default.
- W1992946670 sameAs 1992946670 @default.
- W1992946670 citedByCount "1" @default.
- W1992946670 countsByYear W19929466702017 @default.
- W1992946670 crossrefType "journal-article" @default.
- W1992946670 hasAuthorship W1992946670A5017373674 @default.
- W1992946670 hasAuthorship W1992946670A5080410165 @default.
- W1992946670 hasAuthorship W1992946670A5090950794 @default.
- W1992946670 hasConcept C111919701 @default.
- W1992946670 hasConcept C15490471 @default.
- W1992946670 hasConcept C155164980 @default.
- W1992946670 hasConcept C160145004 @default.
- W1992946670 hasConcept C170493617 @default.
- W1992946670 hasConcept C185592680 @default.
- W1992946670 hasConcept C2779245659 @default.
- W1992946670 hasConcept C2780133158 @default.
- W1992946670 hasConcept C2780799671 @default.
- W1992946670 hasConcept C41008148 @default.
- W1992946670 hasConcept C55493867 @default.
- W1992946670 hasConcept C71924100 @default.
- W1992946670 hasConcept C98274493 @default.
- W1992946670 hasConceptScore W1992946670C111919701 @default.
- W1992946670 hasConceptScore W1992946670C15490471 @default.
- W1992946670 hasConceptScore W1992946670C155164980 @default.
- W1992946670 hasConceptScore W1992946670C160145004 @default.
- W1992946670 hasConceptScore W1992946670C170493617 @default.
- W1992946670 hasConceptScore W1992946670C185592680 @default.
- W1992946670 hasConceptScore W1992946670C2779245659 @default.
- W1992946670 hasConceptScore W1992946670C2780133158 @default.
- W1992946670 hasConceptScore W1992946670C2780799671 @default.
- W1992946670 hasConceptScore W1992946670C41008148 @default.
- W1992946670 hasConceptScore W1992946670C55493867 @default.
- W1992946670 hasConceptScore W1992946670C71924100 @default.
- W1992946670 hasConceptScore W1992946670C98274493 @default.
- W1992946670 hasIssue "2" @default.
- W1992946670 hasLocation W19929466701 @default.
- W1992946670 hasOpenAccess W1992946670 @default.
- W1992946670 hasPrimaryLocation W19929466701 @default.
- W1992946670 hasRelatedWork W1992946670 @default.
- W1992946670 hasRelatedWork W2010893335 @default.
- W1992946670 hasRelatedWork W2029263118 @default.
- W1992946670 hasRelatedWork W2057402123 @default.
- W1992946670 hasRelatedWork W2075072901 @default.
- W1992946670 hasRelatedWork W2080991292 @default.
- W1992946670 hasRelatedWork W2083954992 @default.
- W1992946670 hasRelatedWork W2118590048 @default.
- W1992946670 hasRelatedWork W2767735742 @default.
- W1992946670 hasRelatedWork W4311480237 @default.
- W1992946670 hasVolume "2" @default.
- W1992946670 isParatext "false" @default.
- W1992946670 isRetracted "false" @default.
- W1992946670 magId "1992946670" @default.
- W1992946670 workType "article" @default.