Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992949922> ?p ?o ?g. }
- W1992949922 endingPage "258" @default.
- W1992949922 startingPage "247" @default.
- W1992949922 abstract "The pathways of Li + transport in neuroblastoma × glioma hybrid cells were studied at 2 mM external Li + . Five components of Li + transport were identified. (1) A Na + -dependent Li + countertransport system mediating Li + transport in both directions across the plasma membrane. This transport pathway is insensitive to ouabain or external K + . It shows trans-stimulation (i.e. acceleration of Li + extrusion by external Na + and stimulation of Li + uptake by internal Na + ) and cis-inhibition (i.e. reduction of Li + uptake by external Na + ). (2) The Na + K + pump mediates Li + uptake but not Li + release in cells with physiological Na + and K + content. Li + uptake by the pump in choline media is inhibited by both external Na + and K + . In Na + media, external K + exhibits a biphasic effect: in concentrations up to about 1 mM, K + accelerates, and at higher concentrations, K + inhibits, Li + uptake by the pump. (3) Li + can enter the voltage-dependent Na + channel. Li + uptake through this pathway is stimulated by veratridine and scorpion toxin, the stimulation being blocked by tetrodotoxin. Residual pathways comprise (4) a saturable component, which is comparable to basal Na + uptake, and (5) a ouabain-resistant component promoting Li + extrusion against an electrochemical gradient in choline media. The mechanisms for Li + extrusion described here possibly explain how neuronal cells maintain the steady-state ratio of internal to external Li + below 1 during chronic exposure to 1–2 mM external Li + ." @default.
- W1992949922 created "2016-06-24" @default.
- W1992949922 creator A5046476020 @default.
- W1992949922 creator A5052123124 @default.
- W1992949922 date "1982-12-01" @default.
- W1992949922 modified "2023-09-23" @default.
- W1992949922 title "Transport pathways for lithium ions in neuroblastoma × glioma hybrid cells at ‘therapeutic’ concentrations of Li+" @default.
- W1992949922 cites W1499628760 @default.
- W1992949922 cites W1592918949 @default.
- W1992949922 cites W1606256000 @default.
- W1992949922 cites W1775749144 @default.
- W1992949922 cites W1953498369 @default.
- W1992949922 cites W1964119220 @default.
- W1992949922 cites W1969949448 @default.
- W1992949922 cites W1977247873 @default.
- W1992949922 cites W1977932484 @default.
- W1992949922 cites W1978013916 @default.
- W1992949922 cites W1980627668 @default.
- W1992949922 cites W1992491895 @default.
- W1992949922 cites W1992970418 @default.
- W1992949922 cites W1994124519 @default.
- W1992949922 cites W1998039209 @default.
- W1992949922 cites W2003218346 @default.
- W1992949922 cites W2003677482 @default.
- W1992949922 cites W2007756262 @default.
- W1992949922 cites W2010629411 @default.
- W1992949922 cites W2011502729 @default.
- W1992949922 cites W2022765359 @default.
- W1992949922 cites W2022771372 @default.
- W1992949922 cites W2043420727 @default.
- W1992949922 cites W2049045400 @default.
- W1992949922 cites W2049225842 @default.
- W1992949922 cites W2049819604 @default.
- W1992949922 cites W2054366399 @default.
- W1992949922 cites W2064337713 @default.
- W1992949922 cites W2064382513 @default.
- W1992949922 cites W2065748352 @default.
- W1992949922 cites W2067173343 @default.
- W1992949922 cites W2070573309 @default.
- W1992949922 cites W2073725508 @default.
- W1992949922 cites W2088641039 @default.
- W1992949922 cites W2092109943 @default.
- W1992949922 cites W2096595229 @default.
- W1992949922 cites W2111207891 @default.
- W1992949922 cites W2133877107 @default.
- W1992949922 cites W2150323741 @default.
- W1992949922 cites W2170804639 @default.
- W1992949922 cites W2173520866 @default.
- W1992949922 cites W2275222709 @default.
- W1992949922 cites W2408468150 @default.
- W1992949922 cites W2409877862 @default.
- W1992949922 cites W3163606667 @default.
- W1992949922 cites W4230194566 @default.
- W1992949922 doi "https://doi.org/10.1016/0006-8993(82)90392-4" @default.
- W1992949922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7150952" @default.
- W1992949922 hasPublicationYear "1982" @default.
- W1992949922 type Work @default.
- W1992949922 sameAs 1992949922 @default.
- W1992949922 citedByCount "26" @default.
- W1992949922 countsByYear W19929499222014 @default.
- W1992949922 countsByYear W19929499222016 @default.
- W1992949922 countsByYear W19929499222023 @default.
- W1992949922 crossrefType "journal-article" @default.
- W1992949922 hasAuthorship W1992949922A5046476020 @default.
- W1992949922 hasAuthorship W1992949922A5052123124 @default.
- W1992949922 hasConcept C12554922 @default.
- W1992949922 hasConcept C134018914 @default.
- W1992949922 hasConcept C178790620 @default.
- W1992949922 hasConcept C185592680 @default.
- W1992949922 hasConcept C24998067 @default.
- W1992949922 hasConcept C2776741303 @default.
- W1992949922 hasConcept C2776986425 @default.
- W1992949922 hasConcept C2778375661 @default.
- W1992949922 hasConcept C2778541603 @default.
- W1992949922 hasConcept C2779133857 @default.
- W1992949922 hasConcept C2781123555 @default.
- W1992949922 hasConcept C41625074 @default.
- W1992949922 hasConcept C50952357 @default.
- W1992949922 hasConcept C537181965 @default.
- W1992949922 hasConcept C55493867 @default.
- W1992949922 hasConcept C86803240 @default.
- W1992949922 hasConcept C99975950 @default.
- W1992949922 hasConceptScore W1992949922C12554922 @default.
- W1992949922 hasConceptScore W1992949922C134018914 @default.
- W1992949922 hasConceptScore W1992949922C178790620 @default.
- W1992949922 hasConceptScore W1992949922C185592680 @default.
- W1992949922 hasConceptScore W1992949922C24998067 @default.
- W1992949922 hasConceptScore W1992949922C2776741303 @default.
- W1992949922 hasConceptScore W1992949922C2776986425 @default.
- W1992949922 hasConceptScore W1992949922C2778375661 @default.
- W1992949922 hasConceptScore W1992949922C2778541603 @default.
- W1992949922 hasConceptScore W1992949922C2779133857 @default.
- W1992949922 hasConceptScore W1992949922C2781123555 @default.
- W1992949922 hasConceptScore W1992949922C41625074 @default.
- W1992949922 hasConceptScore W1992949922C50952357 @default.
- W1992949922 hasConceptScore W1992949922C537181965 @default.
- W1992949922 hasConceptScore W1992949922C55493867 @default.
- W1992949922 hasConceptScore W1992949922C86803240 @default.