FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992969888> ?p ?o ?g. }

• W1992969888 endingPage "9" @default.
• W1992969888 startingPage "1" @default.
• W1992969888 abstract "Mechanisms of angiotensin II and cAMP regulating the expression of angiotensin II type 1 (AT(1)) receptor mRNA were studied in neonatal rat cardiomyocytes. Angiotensin II induced a transient decrease of AT(1)-mRNA expression in time- and dose-dependent manner. Maximal decrease (49.2 +/- 9.5% of control) occurred at 6 h of angiotensin II (10 nmol/l) treatment. AT(1) receptor antagonists 4-ethyl-2-n-propyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole-5-carboxylic acid (DMP811) and losartan as well as 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) reversed the down-regulation of AT(1)-mRNA expression. 6 h of phorbol 12-myristate 13-acetate (PMA) stimulation caused a decrease of AT(1)-mRNA level. Treatment by angiotensin II plus actinomycin D for 6 h produced the same effect as actinomycin D alone. These results suggest that angiotensin II down-regulates AT(1)-mRNA level of rat cardiomyocytes by inhibiting the transcription of AT(1) gene, which is mediated by AT(1) receptor and related to the activation of protein kinase C. Stimulation by forskolin plus 3-isobutyl-1-methyl-xanthine (IBMX) decreased the expression of AT(1)-mRNA to 68.1 +/- 21.5% of control at 6 h treatment; while increased to 207.9 +/- 27.1% of control at 48 h treatment. A series of 5'-upstream deletion mutants of AT(1A) promoter were produced and then were recombined with pGL(3) basic vector utilizing luciferase as reporter gene. Among all the constructors, p(-201/+ 74)Luc was of the highest luciferase activity (5.9 times higher than control) after stimulation by forskolin for 48 h. Further deletion from -201 to -61 resulted in a large decrease of activity. These results indicate that cAMP induces a time-dependent bi-directional regulation of AT(1)-mRNA expression. The cAMP responsible element (CRE) cis-element located in the region -201/-61 of rat AT(1A) promoter is forskolin inducible, which may mediate the up-regulation of AT(1)-mRNA expression induced by cAMP long-lasting stimulation." @default.
• W1992969888 created "2016-06-24" @default.
• W1992969888 creator A5008171524 @default.
• W1992969888 creator A5021591848 @default.
• W1992969888 creator A5050457451 @default.
• W1992969888 creator A5056947292 @default.
• W1992969888 creator A5061398009 @default.
• W1992969888 creator A5075814102 @default.
• W1992969888 date "2002-07-01" @default.
• W1992969888 modified "2023-10-11" @default.
• W1992969888 title "Angiotensin II and cAMP regulate AT1-mRNA expression in rat cardiomyocytes by transcriptional mechanism" @default.
• W1992969888 cites W1821554906 @default.
• W1992969888 cites W1965570459 @default.
• W1992969888 cites W1967561584 @default.
• W1992969888 cites W1976843785 @default.
• W1992969888 cites W1981935901 @default.
• W1992969888 cites W1982115885 @default.
• W1992969888 cites W1997261857 @default.
• W1992969888 cites W2017800047 @default.
• W1992969888 cites W2018338404 @default.
• W1992969888 cites W2020181071 @default.
• W1992969888 cites W2027498490 @default.
• W1992969888 cites W2030832817 @default.
• W1992969888 cites W2044799513 @default.
• W1992969888 cites W2045209465 @default.
• W1992969888 cites W2045912865 @default.
• W1992969888 cites W2063948711 @default.
• W1992969888 cites W2065332105 @default.
• W1992969888 cites W2106929179 @default.
• W1992969888 cites W2115728523 @default.
• W1992969888 cites W2157783873 @default.
• W1992969888 cites W2336730706 @default.
• W1992969888 cites W4237899901 @default.
• W1992969888 cites W4294216491 @default.
• W1992969888 doi "https://doi.org/10.1016/s0014-2999(02)01900-3" @default.
• W1992969888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12126964" @default.
• W1992969888 hasPublicationYear "2002" @default.
• W1992969888 type Work @default.
• W1992969888 sameAs 1992969888 @default.
• W1992969888 citedByCount "14" @default.
• W1992969888 countsByYear W19929698882013 @default.
• W1992969888 countsByYear W19929698882015 @default.
• W1992969888 countsByYear W19929698882017 @default.
• W1992969888 countsByYear W19929698882018 @default.
• W1992969888 countsByYear W19929698882019 @default.
• W1992969888 countsByYear W19929698882023 @default.
• W1992969888 crossrefType "journal-article" @default.
• W1992969888 hasAuthorship W1992969888A5008171524 @default.
• W1992969888 hasAuthorship W1992969888A5021591848 @default.
• W1992969888 hasAuthorship W1992969888A5050457451 @default.
• W1992969888 hasAuthorship W1992969888A5056947292 @default.
• W1992969888 hasAuthorship W1992969888A5061398009 @default.
• W1992969888 hasAuthorship W1992969888A5075814102 @default.
• W1992969888 hasConcept C104317684 @default.
• W1992969888 hasConcept C104849204 @default.
• W1992969888 hasConcept C105580179 @default.
• W1992969888 hasConcept C123915805 @default.
• W1992969888 hasConcept C126322002 @default.
• W1992969888 hasConcept C134018914 @default.
• W1992969888 hasConcept C150194340 @default.
• W1992969888 hasConcept C153911025 @default.
• W1992969888 hasConcept C170493617 @default.
• W1992969888 hasConcept C185592680 @default.
• W1992969888 hasConcept C195794163 @default.
• W1992969888 hasConcept C198710026 @default.
• W1992969888 hasConcept C24998067 @default.
• W1992969888 hasConcept C2779276759 @default.
• W1992969888 hasConcept C2780043322 @default.
• W1992969888 hasConcept C2780288358 @default.
• W1992969888 hasConcept C2781298581 @default.
• W1992969888 hasConcept C2908929049 @default.
• W1992969888 hasConcept C55493867 @default.
• W1992969888 hasConcept C62478195 @default.
• W1992969888 hasConcept C71924100 @default.
• W1992969888 hasConcept C84393581 @default.
• W1992969888 hasConcept C86803240 @default.
• W1992969888 hasConceptScore W1992969888C104317684 @default.
• W1992969888 hasConceptScore W1992969888C104849204 @default.
• W1992969888 hasConceptScore W1992969888C105580179 @default.
• W1992969888 hasConceptScore W1992969888C123915805 @default.
• W1992969888 hasConceptScore W1992969888C126322002 @default.
• W1992969888 hasConceptScore W1992969888C134018914 @default.
• W1992969888 hasConceptScore W1992969888C150194340 @default.
• W1992969888 hasConceptScore W1992969888C153911025 @default.
• W1992969888 hasConceptScore W1992969888C170493617 @default.
• W1992969888 hasConceptScore W1992969888C185592680 @default.
• W1992969888 hasConceptScore W1992969888C195794163 @default.
• W1992969888 hasConceptScore W1992969888C198710026 @default.
• W1992969888 hasConceptScore W1992969888C24998067 @default.
• W1992969888 hasConceptScore W1992969888C2779276759 @default.
• W1992969888 hasConceptScore W1992969888C2780043322 @default.
• W1992969888 hasConceptScore W1992969888C2780288358 @default.
• W1992969888 hasConceptScore W1992969888C2781298581 @default.
• W1992969888 hasConceptScore W1992969888C2908929049 @default.
• W1992969888 hasConceptScore W1992969888C55493867 @default.
• W1992969888 hasConceptScore W1992969888C62478195 @default.
• W1992969888 hasConceptScore W1992969888C71924100 @default.
• W1992969888 hasConceptScore W1992969888C84393581 @default.

• next