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• W1992974038 abstract "Methamphetamine is a psychomotor stimulant that produces hyperlocomotion in rodents. Limonene (a cyclic terpene from citrus essential oils) has been reported to induce sedative effects. In this study, we demonstrated that limonene administration significantly inhibited serotonin (5-hydroxytryptamine, 5-HT)-induced head twitch response in mice. In rats, pretreatment with limonene decreased hyperlocomotion induced by methamphetamine injection. In addition, limonene reversed the increase in dopamine levels in the nucleus accumbens of rats given methamphetamine. These results suggest that limonene may inhibit stimulant-induced behavioral changes via regulating dopamine levels and 5-HT receptor function." @default.
• W1992974038 created "2016-06-24" @default.
• W1992974038 creator A5088567252 @default.
• W1992974038 date "2014-05-01" @default.
• W1992974038 modified "2023-10-18" @default.
• W1992974038 title "Limonene inhibits methamphetamine-induced locomotor activity via regulation of 5-HT neuronal function and dopamine release" @default.
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• W1992974038 doi "https://doi.org/10.1016/j.phymed.2013.12.004" @default.
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