FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992979998> ?p ?o ?g. }

• W1992979998 endingPage "810" @default.
• W1992979998 startingPage "802" @default.
• W1992979998 abstract "Dexamethasone ± thalidomide with infusion of cisplatin, doxorubicin, cyclophosphamide, and etoposide [D(T)PACE] is generally reserved as salvage therapy for aggressive multiple myeloma (MM) or plasma cell leukaemia (PCL) resistant to conventional therapies. The efficacy and durability of this potentially toxic regimen in this setting is unclear. We identified 75 patients who received D(T)PACE for relapsed/refractory MM at two tertiary care centres: Princess Margaret Hospital, Toronto and Mayo Clinic Arizona. At time of D(T)PACE, 16 patients had PCL and three patients had leptomeningeal disease. Patients were heavily pretreated (median three prior regimens, range 1-12; prior autologous stem cell transplant [ASCT] 33%). Overall response rate was 49% (very-good partial response 16%, partial response 33%) with stable disease in an additional 36%. Median progression-free survival (PFS) was 5·5 months (95% confidence interval [CI]:4·3-9·8); overall survival (OS) 14·0 months (95% CI:8·7-19·3). Thirty-five patients proceeded to ASCT or clinical trial, with median PFS for this subset of 13·4 months (95% CI:7·7-20·1) and OS 20·5 months (95% CI:14·8-63·8). D(T)PACE is an effective salvage therapy for heavily pretreated MM patients. Although the overall response rate of 49% in this poor prognosis cohort is reasonable, the PFS is short, suggesting the best role for D(T)PACE is in bridging to definitive therapy, such as transplantation." @default.
• W1992979998 created "2016-06-24" @default.
• W1992979998 creator A5006888644 @default.
• W1992979998 creator A5019526963 @default.
• W1992979998 creator A5043490010 @default.
• W1992979998 creator A5054254800 @default.
• W1992979998 creator A5058598134 @default.
• W1992979998 creator A5060412535 @default.
• W1992979998 creator A5067291402 @default.
• W1992979998 creator A5068398472 @default.
• W1992979998 creator A5069106696 @default.
• W1992979998 creator A5073327231 @default.
• W1992979998 creator A5082712392 @default.
• W1992979998 date "2013-04-18" @default.
• W1992979998 modified "2023-10-18" @default.
• W1992979998 title "D(T)PACE as salvage therapy for aggressive or refractory multiple myeloma" @default.
• W1992979998 cites W1992464801 @default.
• W1992979998 cites W2011871138 @default.
• W1992979998 cites W2018491765 @default.
• W1992979998 cites W2020778579 @default.
• W1992979998 cites W2051764726 @default.
• W1992979998 cites W2066800926 @default.
• W1992979998 cites W2069679926 @default.
• W1992979998 cites W2072077329 @default.
• W1992979998 cites W2089311432 @default.
• W1992979998 cites W2103018859 @default.
• W1992979998 cites W2124240218 @default.
• W1992979998 cites W2136373453 @default.
• W1992979998 cites W2151595053 @default.
• W1992979998 cites W2162610784 @default.
• W1992979998 cites W2169336006 @default.
• W1992979998 cites W2609930254 @default.
• W1992979998 cites W4293241248 @default.
• W1992979998 doi "https://doi.org/10.1111/bjh.12325" @default.
• W1992979998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23594335" @default.
• W1992979998 hasPublicationYear "2013" @default.
• W1992979998 type Work @default.
• W1992979998 sameAs 1992979998 @default.
• W1992979998 citedByCount "44" @default.
• W1992979998 countsByYear W19929799982013 @default.
• W1992979998 countsByYear W19929799982014 @default.
• W1992979998 countsByYear W19929799982015 @default.
• W1992979998 countsByYear W19929799982016 @default.
• W1992979998 countsByYear W19929799982017 @default.
• W1992979998 countsByYear W19929799982018 @default.
• W1992979998 countsByYear W19929799982019 @default.
• W1992979998 countsByYear W19929799982020 @default.
• W1992979998 countsByYear W19929799982021 @default.
• W1992979998 countsByYear W19929799982022 @default.
• W1992979998 countsByYear W19929799982023 @default.
• W1992979998 crossrefType "journal-article" @default.
• W1992979998 hasAuthorship W1992979998A5006888644 @default.
• W1992979998 hasAuthorship W1992979998A5019526963 @default.
• W1992979998 hasAuthorship W1992979998A5043490010 @default.
• W1992979998 hasAuthorship W1992979998A5054254800 @default.
• W1992979998 hasAuthorship W1992979998A5058598134 @default.
• W1992979998 hasAuthorship W1992979998A5060412535 @default.
• W1992979998 hasAuthorship W1992979998A5067291402 @default.
• W1992979998 hasAuthorship W1992979998A5068398472 @default.
• W1992979998 hasAuthorship W1992979998A5069106696 @default.
• W1992979998 hasAuthorship W1992979998A5073327231 @default.
• W1992979998 hasAuthorship W1992979998A5082712392 @default.
• W1992979998 hasBestOaLocation W19929799981 @default.
• W1992979998 hasConcept C121332964 @default.
• W1992979998 hasConcept C126322002 @default.
• W1992979998 hasConcept C141071460 @default.
• W1992979998 hasConcept C142424586 @default.
• W1992979998 hasConcept C2776364478 @default.
• W1992979998 hasConcept C2776694085 @default.
• W1992979998 hasConcept C2777408962 @default.
• W1992979998 hasConcept C2778119113 @default.
• W1992979998 hasConcept C2780775027 @default.
• W1992979998 hasConcept C2781413609 @default.
• W1992979998 hasConcept C2911091166 @default.
• W1992979998 hasConcept C71924100 @default.
• W1992979998 hasConcept C72563966 @default.
• W1992979998 hasConcept C87355193 @default.
• W1992979998 hasConceptScore W1992979998C121332964 @default.
• W1992979998 hasConceptScore W1992979998C126322002 @default.
• W1992979998 hasConceptScore W1992979998C141071460 @default.
• W1992979998 hasConceptScore W1992979998C142424586 @default.
• W1992979998 hasConceptScore W1992979998C2776364478 @default.
• W1992979998 hasConceptScore W1992979998C2776694085 @default.
• W1992979998 hasConceptScore W1992979998C2777408962 @default.
• W1992979998 hasConceptScore W1992979998C2778119113 @default.
• W1992979998 hasConceptScore W1992979998C2780775027 @default.
• W1992979998 hasConceptScore W1992979998C2781413609 @default.
• W1992979998 hasConceptScore W1992979998C2911091166 @default.
• W1992979998 hasConceptScore W1992979998C71924100 @default.
• W1992979998 hasConceptScore W1992979998C72563966 @default.
• W1992979998 hasConceptScore W1992979998C87355193 @default.
• W1992979998 hasIssue "6" @default.
• W1992979998 hasLocation W19929799981 @default.
• W1992979998 hasLocation W19929799982 @default.
• W1992979998 hasOpenAccess W1992979998 @default.
• W1992979998 hasPrimaryLocation W19929799981 @default.
• W1992979998 hasRelatedWork W2040492280 @default.
• W1992979998 hasRelatedWork W2066140364 @default.

• next