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- W1992982995 abstract "The racemic 7-methyl-7-hydroxy-2,3-benzo[c]octa-1,6-olide, the analog of natural product (6R)-3,7-dimethyl-7-hydroxy-2-octen-1,6-olide, was totally synthesized using easily available (E)-2-(2-carboxyvinyl)benzoic acid as a raw material in nine-step reactions including three key steps of Wittig reaction, epoxidation, and cyclization, with an overall yield of 10.3%. The bioassay results showed that ( ± )-2 exhibited stronger antifungal activity than the natural product ( ± )-1 and (R)-1 against Alternaria solani with an EC50 value of 27.36 μg/ml." @default.
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- W1992982995 date "2014-01-23" @default.
- W1992982995 modified "2023-09-25" @default.
- W1992982995 title "Synthesis and antifungal activity of 7-methyl-7-hydroxy-2,3-benzo[c]octa-1,6-olide" @default.
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- W1992982995 doi "https://doi.org/10.1080/10286020.2013.879121" @default.
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