Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992986317> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1992986317 endingPage "4029" @default.
- W1992986317 startingPage "4025" @default.
- W1992986317 abstract "The in vitro toxicities of 19 analogues of deoxyadenosine were tested using a panel of human melanoma cell lines including two lines sensitive to deoxyadenosine and deoxyinosine. The 2-fluoro-, 2-chloro-, 2-bromo- and 2-amino-8-aza derivatives were the most toxic and showed selectivity against deoxyadenosine-sensitive cells. 2-Bromodeoxyadenosine (BrdAdo) and its 5'-phosphate were less potent than the chloro compound but showed the greatest selectivity. In further studies of BrdAdo a third sensitive melanoma line was identified of the eight tested. A treatment time of 24 hr or more was required to develop toxicity to BrAdo; this could be prevented by deoxycytidine or cytidine added to the medium but not by other nucleosides. Flow cytometry showed that BrdAdo blocked cells in the G1 and S phases of the cell cycle. DNA synthesis as judged by thymidine incorporation was rapidly inhibited by BrdAdo to an extent which reflected the sensitivity of the particular cell line; RNA synthesis was less affected. Exposure to BrdAdo for 48 hr induced breaks in the preformed DNA of sensitive but not resistant cells. The results suggest that the toxicity of BrdAdo is associated with prolonged inhibition of DNA synthesis and subsequent DNA fragmentation." @default.
- W1992986317 created "2016-06-24" @default.
- W1992986317 creator A5003544014 @default.
- W1992986317 creator A5034981457 @default.
- W1992986317 creator A5079957920 @default.
- W1992986317 date "1986-11-01" @default.
- W1992986317 modified "2023-09-25" @default.
- W1992986317 title "Selective toxicity of deoxyadenosine analogues in human melanoma cell lines" @default.
- W1992986317 cites W121485390 @default.
- W1992986317 cites W1990699846 @default.
- W1992986317 cites W1999166980 @default.
- W1992986317 cites W2003975878 @default.
- W1992986317 cites W2006416369 @default.
- W1992986317 cites W2075377689 @default.
- W1992986317 cites W2082044786 @default.
- W1992986317 cites W2083493209 @default.
- W1992986317 cites W2086228433 @default.
- W1992986317 cites W2086984633 @default.
- W1992986317 cites W2094576147 @default.
- W1992986317 cites W2096208778 @default.
- W1992986317 cites W2107096255 @default.
- W1992986317 cites W2119263245 @default.
- W1992986317 doi "https://doi.org/10.1016/0006-2952(86)90022-5" @default.
- W1992986317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2430574" @default.
- W1992986317 hasPublicationYear "1986" @default.
- W1992986317 type Work @default.
- W1992986317 sameAs 1992986317 @default.
- W1992986317 citedByCount "25" @default.
- W1992986317 crossrefType "journal-article" @default.
- W1992986317 hasAuthorship W1992986317A5003544014 @default.
- W1992986317 hasAuthorship W1992986317A5034981457 @default.
- W1992986317 hasAuthorship W1992986317A5079957920 @default.
- W1992986317 hasConcept C109316439 @default.
- W1992986317 hasConcept C1491633281 @default.
- W1992986317 hasConcept C153911025 @default.
- W1992986317 hasConcept C178790620 @default.
- W1992986317 hasConcept C181199279 @default.
- W1992986317 hasConcept C185592680 @default.
- W1992986317 hasConcept C202751555 @default.
- W1992986317 hasConcept C2777108182 @default.
- W1992986317 hasConcept C2780636463 @default.
- W1992986317 hasConcept C2781184954 @default.
- W1992986317 hasConcept C29537977 @default.
- W1992986317 hasConcept C29730261 @default.
- W1992986317 hasConcept C54355233 @default.
- W1992986317 hasConcept C552990157 @default.
- W1992986317 hasConcept C55493867 @default.
- W1992986317 hasConcept C64241487 @default.
- W1992986317 hasConcept C81885089 @default.
- W1992986317 hasConcept C86803240 @default.
- W1992986317 hasConceptScore W1992986317C109316439 @default.
- W1992986317 hasConceptScore W1992986317C1491633281 @default.
- W1992986317 hasConceptScore W1992986317C153911025 @default.
- W1992986317 hasConceptScore W1992986317C178790620 @default.
- W1992986317 hasConceptScore W1992986317C181199279 @default.
- W1992986317 hasConceptScore W1992986317C185592680 @default.
- W1992986317 hasConceptScore W1992986317C202751555 @default.
- W1992986317 hasConceptScore W1992986317C2777108182 @default.
- W1992986317 hasConceptScore W1992986317C2780636463 @default.
- W1992986317 hasConceptScore W1992986317C2781184954 @default.
- W1992986317 hasConceptScore W1992986317C29537977 @default.
- W1992986317 hasConceptScore W1992986317C29730261 @default.
- W1992986317 hasConceptScore W1992986317C54355233 @default.
- W1992986317 hasConceptScore W1992986317C552990157 @default.
- W1992986317 hasConceptScore W1992986317C55493867 @default.
- W1992986317 hasConceptScore W1992986317C64241487 @default.
- W1992986317 hasConceptScore W1992986317C81885089 @default.
- W1992986317 hasConceptScore W1992986317C86803240 @default.
- W1992986317 hasIssue "22" @default.
- W1992986317 hasLocation W19929863171 @default.
- W1992986317 hasLocation W19929863172 @default.
- W1992986317 hasOpenAccess W1992986317 @default.
- W1992986317 hasPrimaryLocation W19929863171 @default.
- W1992986317 hasRelatedWork W1589604265 @default.
- W1992986317 hasRelatedWork W1610246587 @default.
- W1992986317 hasRelatedWork W1980880528 @default.
- W1992986317 hasRelatedWork W1992986317 @default.
- W1992986317 hasRelatedWork W2016552349 @default.
- W1992986317 hasRelatedWork W2024014622 @default.
- W1992986317 hasRelatedWork W2031387416 @default.
- W1992986317 hasRelatedWork W2072481810 @default.
- W1992986317 hasRelatedWork W2430808823 @default.
- W1992986317 hasRelatedWork W2468119864 @default.
- W1992986317 hasVolume "35" @default.
- W1992986317 isParatext "false" @default.
- W1992986317 isRetracted "false" @default.
- W1992986317 magId "1992986317" @default.
- W1992986317 workType "article" @default.