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- W1992995409 abstract "BACKGROUND: Patients receiving cellular blood components may form HLA antibodies and platelet‐specific alloantibodies. STUDY DESIGN AND METHODS: Serum samples from a cohort of 252 patients with hematologic or oncologic diseases who are receiving cellular blood components were studied for platelet‐reactive antibodies. Specificity of platelet alloantibodies was determined with a panel of typed platelets RESULTS: Platelet‐reactive antibodies were detected in the sera of 113 patients (44.8% of 252), HLA antibodies in the sera of 108 (42.9%), and platelet‐specific antibodies in the sera of 20 (8%). The following platelet‐specific antibodies were identified: anti‐HPA‐5b (n = 10), anti‐HPA‐1b (n = 4), anti‐HPA‐5a (n = 2), anti‐HPA‐1a (n = 1), anti‐HPA‐2b (n = 1), anti‐HPA‐1b+5b (n = 1), and anti‐HPA‐1b+2b (n = 1). Fifteen sera from the 108 patients with anti‐HLA (13.9%) contained additional platelet‐specific alloantibodies, while in 5 sera, platelet‐specific alloantibodies only were detected: anti‐HPA‐5b (n = 4) and anti‐HPA‐1a (n = 1). Of the 108 sera with HLA antibodies, 29 (26.9%) showed discordant results when studied with the lymphocytotoxicity test and the glycoprotein‐specific immunoassay. Ten sera contained panreactive antibodies against platelet glycoproteins (GP) IIb/IIIa, GPIa/IIa, and/or GPIb/IX. Alloimmunization occurred in 58.3 percent of female patients with previous pregnancies, but in only 23.3 percent of those without previous pregnancies (p = 0.0049). CONCLUSION: Platelet alloantibody specificities in transfused patients (predominantly anti‐HPA‐5b and ‐1b with antigen frequencies <30% among whites) differ significantly from those observed in patients with neonatal alloimmune thrombocytopenia or posttransfusion purpura, in whom anti‐HPA‐1a (antigen frequency >95%) is the most prevalent specificity. HLA antibody detection yields discordant results when the lymphocytotoxicity assay and a glycoprotein‐specific immunoglobulin‐binding assay are used." @default.
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- W1992995409 date "2001-06-01" @default.
- W1992995409 modified "2023-10-18" @default.
- W1992995409 title "Platelet alloantibodies in transfused patients" @default.
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- W1992995409 doi "https://doi.org/10.1046/j.1537-2995.2001.41060766.x" @default.
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