Matches in SemOpenAlex for { <https://semopenalex.org/work/W199299907> ?p ?o ?g. }
- W199299907 endingPage "245" @default.
- W199299907 startingPage "237" @default.
- W199299907 abstract "Subjects with Down syndrome exhibit various types of cognitive impairment. Neuropathological and neurochemical studies revealed similarities between Down syndrome and Alzheimer’s disease, cholinergic deficits being the most consistent findings. To explore the potential for cognitive enhancement utilizing nicotinic stimulation, 8 patients with Down syndrome (aged 18.5–31 years) received placebo and a single dose of transdermal nicotine (5mg patch) over 2h in a single-blind, within-subjects repeated measures design. Auditory event-related potentials (ERPs) and neuropsychological tests, comprising digit symbol performance subtest from WAIS-R and the Frankfurt Attention Inventory (FAIR) were performed. Effects of nicotine administration in Down syndrome individuals were a decrease of ERP-P3 latency in 7 of 8 subjects (electrode position Cz: 386.9 ± 24.0ms vs. 363.1 ± 26.9.2 ms, placebo vs. nicotine, respectively; P = 0.058) and an increase of ERP-P3 amplitude in 6 of 8 subjects (electrode position Cz: 17.4 ± 5.5 vs. 18.0 ± 4.5μV, placebo vs. nicotine respectively; P = 0.725). Neuropsychological tests exhibited improvements in digit symbol performance subtest in 4 of 8 subjects and 7 of 8 subjects in the Frankfurt Attention Inventory. These results suggest that stimulating central nicotinic receptors might have an acute cognitive benefit in young adult Down syndrome subjects." @default.
- W199299907 created "2016-06-24" @default.
- W199299907 creator A5003590248 @default.
- W199299907 creator A5058360225 @default.
- W199299907 creator A5059656112 @default.
- W199299907 creator A5061354287 @default.
- W199299907 creator A5067286977 @default.
- W199299907 date "2001-01-01" @default.
- W199299907 modified "2023-10-16" @default.
- W199299907 title "Effects of a single transdermal nicotine dose on cognitive performance in adults with Down syndrome" @default.
- W199299907 cites W1526007128 @default.
- W199299907 cites W1554440479 @default.
- W199299907 cites W1821382173 @default.
- W199299907 cites W1940356484 @default.
- W199299907 cites W1982775869 @default.
- W199299907 cites W1991888228 @default.
- W199299907 cites W2003851201 @default.
- W199299907 cites W2005231549 @default.
- W199299907 cites W2009815181 @default.
- W199299907 cites W2018885303 @default.
- W199299907 cites W2020370964 @default.
- W199299907 cites W2035560355 @default.
- W199299907 cites W2041789591 @default.
- W199299907 cites W2045309216 @default.
- W199299907 cites W2049774481 @default.
- W199299907 cites W2055640659 @default.
- W199299907 cites W2056745213 @default.
- W199299907 cites W2057410920 @default.
- W199299907 cites W2058318308 @default.
- W199299907 cites W2060504746 @default.
- W199299907 cites W2062419094 @default.
- W199299907 cites W2068126223 @default.
- W199299907 cites W2068987805 @default.
- W199299907 cites W2069894189 @default.
- W199299907 cites W2076583086 @default.
- W199299907 cites W2077174214 @default.
- W199299907 cites W2089104779 @default.
- W199299907 doi "https://doi.org/10.1007/978-3-7091-6262-0_19" @default.
- W199299907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11771747" @default.
- W199299907 hasPublicationYear "2001" @default.
- W199299907 type Work @default.
- W199299907 sameAs 199299907 @default.
- W199299907 citedByCount "2" @default.
- W199299907 crossrefType "book-chapter" @default.
- W199299907 hasAuthorship W199299907A5003590248 @default.
- W199299907 hasAuthorship W199299907A5058360225 @default.
- W199299907 hasAuthorship W199299907A5059656112 @default.
- W199299907 hasAuthorship W199299907A5061354287 @default.
- W199299907 hasAuthorship W199299907A5067286977 @default.
- W199299907 hasConcept C118552586 @default.
- W199299907 hasConcept C126322002 @default.
- W199299907 hasConcept C14216870 @default.
- W199299907 hasConcept C142724271 @default.
- W199299907 hasConcept C15744967 @default.
- W199299907 hasConcept C169760540 @default.
- W199299907 hasConcept C169900460 @default.
- W199299907 hasConcept C170493617 @default.
- W199299907 hasConcept C172467417 @default.
- W199299907 hasConcept C188987157 @default.
- W199299907 hasConcept C204787440 @default.
- W199299907 hasConcept C25876315 @default.
- W199299907 hasConcept C27081682 @default.
- W199299907 hasConcept C2779547902 @default.
- W199299907 hasConcept C42219234 @default.
- W199299907 hasConcept C548259974 @default.
- W199299907 hasConcept C71924100 @default.
- W199299907 hasConceptScore W199299907C118552586 @default.
- W199299907 hasConceptScore W199299907C126322002 @default.
- W199299907 hasConceptScore W199299907C14216870 @default.
- W199299907 hasConceptScore W199299907C142724271 @default.
- W199299907 hasConceptScore W199299907C15744967 @default.
- W199299907 hasConceptScore W199299907C169760540 @default.
- W199299907 hasConceptScore W199299907C169900460 @default.
- W199299907 hasConceptScore W199299907C170493617 @default.
- W199299907 hasConceptScore W199299907C172467417 @default.
- W199299907 hasConceptScore W199299907C188987157 @default.
- W199299907 hasConceptScore W199299907C204787440 @default.
- W199299907 hasConceptScore W199299907C25876315 @default.
- W199299907 hasConceptScore W199299907C27081682 @default.
- W199299907 hasConceptScore W199299907C2779547902 @default.
- W199299907 hasConceptScore W199299907C42219234 @default.
- W199299907 hasConceptScore W199299907C548259974 @default.
- W199299907 hasConceptScore W199299907C71924100 @default.
- W199299907 hasLocation W1992999071 @default.
- W199299907 hasLocation W1992999072 @default.
- W199299907 hasOpenAccess W199299907 @default.
- W199299907 hasPrimaryLocation W1992999071 @default.
- W199299907 hasRelatedWork W125047944 @default.
- W199299907 hasRelatedWork W1999543603 @default.
- W199299907 hasRelatedWork W2022684867 @default.
- W199299907 hasRelatedWork W2040422782 @default.
- W199299907 hasRelatedWork W2070995312 @default.
- W199299907 hasRelatedWork W2089111872 @default.
- W199299907 hasRelatedWork W2147183101 @default.
- W199299907 hasRelatedWork W2625887310 @default.
- W199299907 hasRelatedWork W4253315271 @default.
- W199299907 hasRelatedWork W965592079 @default.
- W199299907 isParatext "false" @default.