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- W1993004513 abstract "Long-term depression (LTD) in sensory cortices depends on the activation of NMDA receptors. Here, we report that in visual cortical slices, the induction of LTD (but not long-term potentiation) also requires the activation of receptors coupled to the phospholipase C (PLC) pathway. Using immunolesions in combination with agonists and antagonists, we selectively manipulated the activation of α1 adrenergic, M1 muscarinic, and mGluR5 glutamatergic receptors. Inactivation of these PLC-coupled receptors prevents the induction of LTD, but only when the three receptors were inactivated together. LTD is fully restored by activating any one of them or by supplying intracellular d -myo-inositol-1,4,5-triphosphate (IP 3 ). LTD was also impaired by intracellular application of PLC or IP 3 receptor blockers, and it was absent in mice lacking PLCβ1, the predominant PLC isoform in the forebrain. We propose that visual cortical LTD requires a minimum of PLC activity that can be supplied independently by at least three neurotransmitter systems. This essential requirement places PLC-linked receptors in a unique position to control the induction of LTD and provides a mechanism for gating visual cortical plasticity via extra-retinal inputs in the intact organism." @default.
- W1993004513 created "2016-06-24" @default.
- W1993004513 creator A5003237492 @default.
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- W1993004513 creator A5090537122 @default.
- W1993004513 date "2005-12-07" @default.
- W1993004513 modified "2023-09-23" @default.
- W1993004513 title "Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex" @default.
- W1993004513 cites W1505976679 @default.
- W1993004513 cites W1561430338 @default.
- W1993004513 cites W1564467813 @default.
- W1993004513 cites W1578028098 @default.
- W1993004513 cites W1597131590 @default.
- W1993004513 cites W1602481930 @default.
- W1993004513 cites W1603471307 @default.
- W1993004513 cites W1604228477 @default.
- W1993004513 cites W1618210884 @default.
- W1993004513 cites W1836828237 @default.
- W1993004513 cites W1916896154 @default.
- W1993004513 cites W1963806203 @default.
- W1993004513 cites W1965508391 @default.
- W1993004513 cites W1972897107 @default.
- W1993004513 cites W1981977956 @default.
- W1993004513 cites W1982455588 @default.
- W1993004513 cites W1987124837 @default.
- W1993004513 cites W1989440825 @default.
- W1993004513 cites W1999160850 @default.
- W1993004513 cites W2000460900 @default.
- W1993004513 cites W2000494479 @default.
- W1993004513 cites W2003083934 @default.
- W1993004513 cites W2006423839 @default.
- W1993004513 cites W2009362065 @default.
- W1993004513 cites W2010909249 @default.
- W1993004513 cites W2017615879 @default.
- W1993004513 cites W2025014122 @default.
- W1993004513 cites W2028596158 @default.
- W1993004513 cites W2028985118 @default.
- W1993004513 cites W2029542833 @default.
- W1993004513 cites W2029638208 @default.
- W1993004513 cites W2030193511 @default.
- W1993004513 cites W2032646816 @default.
- W1993004513 cites W2033066785 @default.
- W1993004513 cites W2035322026 @default.
- W1993004513 cites W2038496684 @default.
- W1993004513 cites W2046388858 @default.
- W1993004513 cites W2050066016 @default.
- W1993004513 cites W2054203244 @default.
- W1993004513 cites W2054959632 @default.
- W1993004513 cites W2057478733 @default.
- W1993004513 cites W2059405665 @default.
- W1993004513 cites W2059599887 @default.
- W1993004513 cites W2061405268 @default.
- W1993004513 cites W2062402618 @default.
- W1993004513 cites W2065229967 @default.
- W1993004513 cites W2065389311 @default.
- W1993004513 cites W2071852876 @default.
- W1993004513 cites W2074382776 @default.
- W1993004513 cites W2080252952 @default.
- W1993004513 cites W2081831423 @default.
- W1993004513 cites W2088384944 @default.
- W1993004513 cites W2088433445 @default.
- W1993004513 cites W2089160598 @default.
- W1993004513 cites W2091230743 @default.
- W1993004513 cites W2093545276 @default.
- W1993004513 cites W2095161495 @default.
- W1993004513 cites W2103177297 @default.
- W1993004513 cites W2109208582 @default.
- W1993004513 cites W2110240734 @default.
- W1993004513 cites W2110298861 @default.
- W1993004513 cites W2111627644 @default.
- W1993004513 cites W2116106251 @default.
- W1993004513 cites W2119125561 @default.
- W1993004513 cites W2123067258 @default.
- W1993004513 cites W2129526664 @default.
- W1993004513 cites W2132757296 @default.
- W1993004513 cites W2135068208 @default.
- W1993004513 cites W2138675786 @default.
- W1993004513 cites W2138940294 @default.
- W1993004513 cites W2141911467 @default.
- W1993004513 cites W2145936933 @default.
- W1993004513 cites W2146732533 @default.
- W1993004513 cites W2146893133 @default.
- W1993004513 cites W2147047301 @default.
- W1993004513 cites W2154045630 @default.
- W1993004513 cites W2157055126 @default.
- W1993004513 cites W2162593608 @default.
- W1993004513 cites W2163318744 @default.
- W1993004513 cites W2183530574 @default.
- W1993004513 cites W2288338024 @default.
- W1993004513 cites W2289804469 @default.
- W1993004513 cites W2418344628 @default.
- W1993004513 cites W2471457183 @default.