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- W1993013522 endingPage "855" @default.
- W1993013522 startingPage "845" @default.
- W1993013522 abstract "Since its discovery in the late 1970s considerable research has linked transforming growth factor-beta (TGF-beta) to several human diseases such as fibrosis, auto-immunity and cancer. TGF-beta acts initially as a growth inhibitory factor in early stages of tumour development. In contrast, as tumours evolve, they develop mechanisms to evade the growth-regulatory effects of TGF-beta, resulting in greater tumour invasiveness, increased metastatic potential and inhibition of surrounding immune responses. However, although extensively studied, the molecular mechanisms that trigger tumour cells to switch from TGF-beta-inhibited to TGF-beta-promoted are still not fully understood. Contradictory studies that demonstrate opposite cellular effects mediated by TGF-beta are abundant throughout the literature. This review summarizes the current molecular mechanisms involved in the tumour suppressive and tumour progressive characteristics of TGF-beta in brain tumours. Potential therapeutic agents that target TGF-beta and related proteins being evaluated against brain tumours is also discussed." @default.
- W1993013522 created "2016-06-24" @default.
- W1993013522 creator A5003231470 @default.
- W1993013522 creator A5054088397 @default.
- W1993013522 creator A5061700388 @default.
- W1993013522 date "2008-08-01" @default.
- W1993013522 modified "2023-10-16" @default.
- W1993013522 title "Transforming growth factor-beta (TGF-β) and brain tumours" @default.
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