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• W1993015272 abstract "Background: Various approaches have been used to retain the dosage form in stomach as a way of increasing the gastric residence time, including floatation systems; high-density systems; mucoadhesive systems; magnetic systems; unfoldable, extensible, or swellable systems; and superporous hydrogel systems. Aim : The objective of this study was to prepare and evaluate floating microspheres of rosiglitazone maleate for the prolongation of gastric residence time. Method: The microspheres were prepared by solvent diffusion–evaporation method using ethyl cellulose and hydroxypropylmethylcellulose. A full factorial design was applied to optimize the formulation. Results: Preliminary studies revealed that the polymer:drug ratio, concentration of polymer, and stirring speed significantly affected the characteristics of microspheres. The optimum batch exhibited a prolonged drug release, remained buoyant for >12 hours, high entrapment efficiency, and particle size in the order of 350 μm. Conclusion: The results of 32 full factorial design revealed that the concentration of ethylcellulose 7 cps (X1) and stirring speed (X2) significantly affected drug entrapment efficiency, percentage release after 8 h and particle size of microspheres." @default.
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• W1993015272 date "2009-05-19" @default.
• W1993015272 modified "2023-10-14" @default.
• W1993015272 title "Development and in vitro evaluation of floating rosiglitazone maleate microspheres" @default.
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• W1993015272 doi "https://doi.org/10.1080/03639040802627421" @default.
• W1993015272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19337874" @default.
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