Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993022226> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1993022226 endingPage "247" @default.
- W1993022226 startingPage "247" @default.
- W1993022226 abstract "Amiodarone, a class III antiarrhythmic with beta-adrenergic blocking and antimuscarinic properties, has a wide spectrum of clinical use in humans. This study was conducted to establish the effects of a 25 mg/kg q12h loading dose and a 30 mg/kg q24h maintenance dose of amiodarone, each given PO for 3.5 weeks, on systemic arterial pressure, echocardiographic (ECHO) indices of left ventricular function, ECGs, exercise tolerance, and serum biochemistries in adult, clinically normal dogs. Means were calculated and were compared by analysis of variance with repeated measures. When a significant F statistic was identified, specific means were compared by Bonferroni's post hoc test. Body weight and heart rate (HR) decreased, and PQ, QT, and corrected QT (QTc) increased significantly (P < .05) for the weeks that the dogs received the loading dose, but all parameters returned to values the same as those in the pretest for the weeks when dogs received the maintenance dose. Serum activity of hepatic enzyme activities and cholesterol concentrations increased, and serum concentrations of thyroid hormones (triiodothyronine [T3] and thyroxine [T4]), phosphorous, and total carbon dioxide decreased. The changes in PQ, QT, and QTc are similar to those obtained previously, but the detailed ECG and ECHO observations have not been reported. A dose of 25 mg/kg q12h, but not 30 mg/kg q24h, is an appetite suppressant, and the lower dose produces neither ECG nor ECHO changes of clinical or toxicological significance in normal dogs." @default.
- W1993022226 created "2016-06-24" @default.
- W1993022226 creator A5013447711 @default.
- W1993022226 creator A5021966312 @default.
- W1993022226 creator A5048833151 @default.
- W1993022226 date "2002-01-01" @default.
- W1993022226 modified "2023-09-25" @default.
- W1993022226 title "Effects of Chronic Oral Amiodarone on Left Ventricular Function, ECGs, Serum Chemistries, and Exercise Tolerance in Healthy Dogs" @default.
- W1993022226 cites W17816465 @default.
- W1993022226 cites W1898317481 @default.
- W1993022226 cites W1976055925 @default.
- W1993022226 cites W1979418870 @default.
- W1993022226 cites W1986627719 @default.
- W1993022226 cites W1988057529 @default.
- W1993022226 cites W1995080987 @default.
- W1993022226 cites W1995542023 @default.
- W1993022226 cites W1999378154 @default.
- W1993022226 cites W1999383461 @default.
- W1993022226 cites W2009048447 @default.
- W1993022226 cites W2010386758 @default.
- W1993022226 cites W2020509502 @default.
- W1993022226 cites W2021891155 @default.
- W1993022226 cites W2024858185 @default.
- W1993022226 cites W2028710966 @default.
- W1993022226 cites W2037187539 @default.
- W1993022226 cites W2039138983 @default.
- W1993022226 cites W2041859882 @default.
- W1993022226 cites W2065808951 @default.
- W1993022226 cites W2072298555 @default.
- W1993022226 cites W2078754141 @default.
- W1993022226 cites W2080224289 @default.
- W1993022226 cites W2093604572 @default.
- W1993022226 cites W2112300580 @default.
- W1993022226 cites W2121368106 @default.
- W1993022226 cites W2124278962 @default.
- W1993022226 cites W2146425258 @default.
- W1993022226 cites W2169197323 @default.
- W1993022226 cites W2401532202 @default.
- W1993022226 cites W2409973201 @default.
- W1993022226 doi "https://doi.org/10.1892/0891-6640(2002)016<0247:eocoao>2.3.co;2" @default.
- W1993022226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12041653" @default.
- W1993022226 hasPublicationYear "2002" @default.
- W1993022226 type Work @default.
- W1993022226 sameAs 1993022226 @default.
- W1993022226 citedByCount "5" @default.
- W1993022226 countsByYear W19930222262014 @default.
- W1993022226 countsByYear W19930222262015 @default.
- W1993022226 countsByYear W19930222262017 @default.
- W1993022226 crossrefType "journal-article" @default.
- W1993022226 hasAuthorship W1993022226A5013447711 @default.
- W1993022226 hasAuthorship W1993022226A5021966312 @default.
- W1993022226 hasAuthorship W1993022226A5048833151 @default.
- W1993022226 hasConcept C118441451 @default.
- W1993022226 hasConcept C126322002 @default.
- W1993022226 hasConcept C134018914 @default.
- W1993022226 hasConcept C164705383 @default.
- W1993022226 hasConcept C2777953023 @default.
- W1993022226 hasConcept C2778094803 @default.
- W1993022226 hasConcept C2778288131 @default.
- W1993022226 hasConcept C2779161974 @default.
- W1993022226 hasConcept C71315377 @default.
- W1993022226 hasConcept C71924100 @default.
- W1993022226 hasConcept C84393581 @default.
- W1993022226 hasConceptScore W1993022226C118441451 @default.
- W1993022226 hasConceptScore W1993022226C126322002 @default.
- W1993022226 hasConceptScore W1993022226C134018914 @default.
- W1993022226 hasConceptScore W1993022226C164705383 @default.
- W1993022226 hasConceptScore W1993022226C2777953023 @default.
- W1993022226 hasConceptScore W1993022226C2778094803 @default.
- W1993022226 hasConceptScore W1993022226C2778288131 @default.
- W1993022226 hasConceptScore W1993022226C2779161974 @default.
- W1993022226 hasConceptScore W1993022226C71315377 @default.
- W1993022226 hasConceptScore W1993022226C71924100 @default.
- W1993022226 hasConceptScore W1993022226C84393581 @default.
- W1993022226 hasIssue "3" @default.
- W1993022226 hasLocation W19930222261 @default.
- W1993022226 hasLocation W19930222262 @default.
- W1993022226 hasOpenAccess W1993022226 @default.
- W1993022226 hasPrimaryLocation W19930222261 @default.
- W1993022226 hasRelatedWork W1548669396 @default.
- W1993022226 hasRelatedWork W1966695668 @default.
- W1993022226 hasRelatedWork W1991634850 @default.
- W1993022226 hasRelatedWork W1993392811 @default.
- W1993022226 hasRelatedWork W2037952323 @default.
- W1993022226 hasRelatedWork W2069420617 @default.
- W1993022226 hasRelatedWork W2095639129 @default.
- W1993022226 hasRelatedWork W2118001750 @default.
- W1993022226 hasRelatedWork W2133799251 @default.
- W1993022226 hasRelatedWork W4245320514 @default.
- W1993022226 hasVolume "16" @default.
- W1993022226 isParatext "false" @default.
- W1993022226 isRetracted "false" @default.
- W1993022226 magId "1993022226" @default.
- W1993022226 workType "article" @default.