FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993033897> ?p ?o ?g. }

• W1993033897 endingPage "e103272" @default.
• W1993033897 startingPage "e103272" @default.
• W1993033897 abstract "Survival and virulence of the human malaria parasite Plasmodium falciparum during the blood stage of infection critically depend on extensive host cell refurbishments mediated through export of numerous parasite proteins into the host cell. The parasite-derived membranous structures called Maurer's clefts (MC) play an important role in protein trafficking from the parasite to the red blood cell membrane. However, their specific function has yet to be determined. We identified and characterized a new MC membrane protein, termed small exported membrane protein 1 (SEMP1). Upon invasion it is exported into the RBC cytosol where it inserts into the MCs before it is partly translocated to the RBC membrane. Using conventional and conditional loss-of-function approaches we showed that SEMP1 is not essential for parasite survival, gametocytogenesis, or PfEMP1 export under culture conditions. Co-IP experiments identified several potential interaction partners, including REX1 and other membrane-associated proteins that were confirmed to co-localize with SEMP1 at MCs. Transcriptome analysis further showed that expression of a number of exported parasite proteins was up-regulated in SEMP1-depleted parasites. By using Co-IP and transcriptome analysis for functional characterization of an exported parasite protein we provide a new starting point for further detailed dissection and characterisation of MC-associated protein complexes." @default.
• W1993033897 created "2016-06-24" @default.
• W1993033897 creator A5012216455 @default.
• W1993033897 creator A5013432533 @default.
• W1993033897 creator A5026181239 @default.
• W1993033897 creator A5028570832 @default.
• W1993033897 creator A5051051823 @default.
• W1993033897 creator A5085052826 @default.
• W1993033897 creator A5088863618 @default.
• W1993033897 date "2014-07-25" @default.
• W1993033897 modified "2023-10-16" @default.
• W1993033897 title "Characterization of the Small Exported Plasmodium falciparum Membrane Protein SEMP1" @default.
• W1993033897 cites W1527127553 @default.
• W1993033897 cites W1595322628 @default.
• W1993033897 cites W1601956283 @default.
• W1993033897 cites W1949772429 @default.
• W1993033897 cites W1973541716 @default.
• W1993033897 cites W1975685743 @default.
• W1993033897 cites W1977922844 @default.
• W1993033897 cites W1979637363 @default.
• W1993033897 cites W2000722649 @default.
• W1993033897 cites W2002869829 @default.
• W1993033897 cites W2009520681 @default.
• W1993033897 cites W2010201271 @default.
• W1993033897 cites W2016266809 @default.
• W1993033897 cites W2016728754 @default.
• W1993033897 cites W2019003837 @default.
• W1993033897 cites W2020251171 @default.
• W1993033897 cites W2023114159 @default.
• W1993033897 cites W2029179276 @default.
• W1993033897 cites W2033929194 @default.
• W1993033897 cites W2035881638 @default.
• W1993033897 cites W2037173275 @default.
• W1993033897 cites W2039227742 @default.
• W1993033897 cites W2041009167 @default.
• W1993033897 cites W2047849307 @default.
• W1993033897 cites W2051913819 @default.
• W1993033897 cites W2058539632 @default.
• W1993033897 cites W2064830352 @default.
• W1993033897 cites W2066686101 @default.
• W1993033897 cites W2078693237 @default.
• W1993033897 cites W2084670771 @default.
• W1993033897 cites W2090685379 @default.
• W1993033897 cites W2094235433 @default.
• W1993033897 cites W2097432311 @default.
• W1993033897 cites W2102517059 @default.
• W1993033897 cites W2104112226 @default.
• W1993033897 cites W2109735813 @default.
• W1993033897 cites W2112798524 @default.
• W1993033897 cites W2117312427 @default.
• W1993033897 cites W2124833370 @default.
• W1993033897 cites W2126071146 @default.
• W1993033897 cites W2126961090 @default.
• W1993033897 cites W2128611502 @default.
• W1993033897 cites W2130923306 @default.
• W1993033897 cites W2145767020 @default.
• W1993033897 cites W2149087378 @default.
• W1993033897 cites W2150926065 @default.
• W1993033897 cites W2168855679 @default.
• W1993033897 cites W2409442395 @default.
• W1993033897 cites W4294107304 @default.
• W1993033897 doi "https://doi.org/10.1371/journal.pone.0103272" @default.
• W1993033897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4111544" @default.
• W1993033897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25062022" @default.
• W1993033897 hasPublicationYear "2014" @default.
• W1993033897 type Work @default.
• W1993033897 sameAs 1993033897 @default.
• W1993033897 citedByCount "21" @default.
• W1993033897 countsByYear W19930338972015 @default.
• W1993033897 countsByYear W19930338972016 @default.
• W1993033897 countsByYear W19930338972017 @default.
• W1993033897 countsByYear W19930338972018 @default.
• W1993033897 countsByYear W19930338972019 @default.
• W1993033897 countsByYear W19930338972020 @default.
• W1993033897 countsByYear W19930338972021 @default.
• W1993033897 countsByYear W19930338972022 @default.
• W1993033897 countsByYear W19930338972023 @default.
• W1993033897 crossrefType "journal-article" @default.
• W1993033897 hasAuthorship W1993033897A5012216455 @default.
• W1993033897 hasAuthorship W1993033897A5013432533 @default.
• W1993033897 hasAuthorship W1993033897A5026181239 @default.
• W1993033897 hasAuthorship W1993033897A5028570832 @default.
• W1993033897 hasAuthorship W1993033897A5051051823 @default.
• W1993033897 hasAuthorship W1993033897A5085052826 @default.
• W1993033897 hasAuthorship W1993033897A5088863618 @default.
• W1993033897 hasBestOaLocation W19930338971 @default.
• W1993033897 hasConcept C104317684 @default.
• W1993033897 hasConcept C136764020 @default.
• W1993033897 hasConcept C144647389 @default.
• W1993033897 hasConcept C150194340 @default.
• W1993033897 hasConcept C162317418 @default.
• W1993033897 hasConcept C181199279 @default.
• W1993033897 hasConcept C203014093 @default.
• W1993033897 hasConcept C2777237215 @default.
• W1993033897 hasConcept C2778048844 @default.
• W1993033897 hasConcept C2778371730 @default.
• W1993033897 hasConcept C2778675580 @default.
• W1993033897 hasConcept C41008148 @default.

• next