Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993043820> ?p ?o ?g. }
- W1993043820 endingPage "1225" @default.
- W1993043820 startingPage "1219" @default.
- W1993043820 abstract "The aim of this study was to investigate the effects of ultraviolet B (UVB) exposure on DNA methylation in patients with systemic lupus erythematosus (SLE) and its significance in the pathogenesis of SLE. T cells from 35 SLE patients and 21 healthy individuals were cultured and irradiated with UVB. The global DNA methylation profiles of the T cells obtained from the patients and controls following irradiation with UVB were assessed using specific monoclonal antibodies for 5‑methylcytosine and analyzed quantitatively through flow cytometry. Real‑time reverse transcription‑polymerase chain reaction (RT‑PCR) was used to analyze the levels of DNA methyltransferase 1 (DNMT1) and methyl CpG binding domain protein 2 (MBD2) in T cells from the patients and controls following UVB irradiation. Significant global DNA hypomethylation was observed in the SLE patients compared with the controls (P<0.01). The SLE patients also had significantly lower levels of DNMT1 mRNA expression (P<0.01) and significantly higher levels of MBD2 mRNA compared with the controls (P<0.01). DNA methylation was decreased following UVB irradiation at two different dosages and the DNA methylation levels of the patients with active SLE were more sensitive to UVB. The level of DNMT1 mRNA was decreased following UVB irradiation at the higher dosage in the patients with active SLE, but no significant difference was observed in MBD2 mRNA expression. UVB exposure is able to inhibit DNA methylation and DNMT1 mRNA expression, which is subsequently involved in the epigenetic mechanism of SLE. The process by which DNA hypomethylation occurs in patients with SLE is complicated and the multiple factors that are involved in DNA methylation and demethylation events require further study." @default.
- W1993043820 created "2016-06-24" @default.
- W1993043820 creator A5000608768 @default.
- W1993043820 creator A5002708668 @default.
- W1993043820 creator A5021555943 @default.
- W1993043820 creator A5039487331 @default.
- W1993043820 creator A5058812525 @default.
- W1993043820 creator A5076139055 @default.
- W1993043820 date "2013-02-18" @default.
- W1993043820 modified "2023-10-18" @default.
- W1993043820 title "Effects of ultraviolet B exposure on DNA methylation in patients with systemic lupus erythematosus" @default.
- W1993043820 cites W1538430276 @default.
- W1993043820 cites W1577875429 @default.
- W1993043820 cites W1605104953 @default.
- W1993043820 cites W1637312052 @default.
- W1993043820 cites W1652583010 @default.
- W1993043820 cites W1823692109 @default.
- W1993043820 cites W1970745149 @default.
- W1993043820 cites W1973869717 @default.
- W1993043820 cites W1994009027 @default.
- W1993043820 cites W1994602086 @default.
- W1993043820 cites W1998631235 @default.
- W1993043820 cites W1999481203 @default.
- W1993043820 cites W2001316126 @default.
- W1993043820 cites W2001864787 @default.
- W1993043820 cites W2008261028 @default.
- W1993043820 cites W2008521296 @default.
- W1993043820 cites W2013359460 @default.
- W1993043820 cites W2014912378 @default.
- W1993043820 cites W2017595171 @default.
- W1993043820 cites W2028418054 @default.
- W1993043820 cites W2034583127 @default.
- W1993043820 cites W2035744678 @default.
- W1993043820 cites W2042515987 @default.
- W1993043820 cites W2047396455 @default.
- W1993043820 cites W2056521900 @default.
- W1993043820 cites W2064999867 @default.
- W1993043820 cites W2074288313 @default.
- W1993043820 cites W2080040722 @default.
- W1993043820 cites W2081195534 @default.
- W1993043820 cites W2084101481 @default.
- W1993043820 cites W2084410329 @default.
- W1993043820 cites W2084747376 @default.
- W1993043820 cites W2098976753 @default.
- W1993043820 cites W2106655704 @default.
- W1993043820 cites W2121082106 @default.
- W1993043820 cites W2122116522 @default.
- W1993043820 cites W2135658911 @default.
- W1993043820 cites W2136219225 @default.
- W1993043820 cites W2137063551 @default.
- W1993043820 cites W2144410175 @default.
- W1993043820 cites W2146203649 @default.
- W1993043820 cites W2148029194 @default.
- W1993043820 cites W2150769574 @default.
- W1993043820 cites W2152497434 @default.
- W1993043820 cites W2159886746 @default.
- W1993043820 cites W2171897475 @default.
- W1993043820 doi "https://doi.org/10.3892/etm.2013.960" @default.
- W1993043820 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3628076" @default.
- W1993043820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23596493" @default.
- W1993043820 hasPublicationYear "2013" @default.
- W1993043820 type Work @default.
- W1993043820 sameAs 1993043820 @default.
- W1993043820 citedByCount "26" @default.
- W1993043820 countsByYear W19930438202014 @default.
- W1993043820 countsByYear W19930438202015 @default.
- W1993043820 countsByYear W19930438202016 @default.
- W1993043820 countsByYear W19930438202017 @default.
- W1993043820 countsByYear W19930438202018 @default.
- W1993043820 countsByYear W19930438202019 @default.
- W1993043820 countsByYear W19930438202020 @default.
- W1993043820 countsByYear W19930438202021 @default.
- W1993043820 countsByYear W19930438202022 @default.
- W1993043820 countsByYear W19930438202023 @default.
- W1993043820 crossrefType "journal-article" @default.
- W1993043820 hasAuthorship W1993043820A5000608768 @default.
- W1993043820 hasAuthorship W1993043820A5002708668 @default.
- W1993043820 hasAuthorship W1993043820A5021555943 @default.
- W1993043820 hasAuthorship W1993043820A5039487331 @default.
- W1993043820 hasAuthorship W1993043820A5058812525 @default.
- W1993043820 hasAuthorship W1993043820A5076139055 @default.
- W1993043820 hasBestOaLocation W19930438201 @default.
- W1993043820 hasConcept C104317684 @default.
- W1993043820 hasConcept C140173407 @default.
- W1993043820 hasConcept C150194340 @default.
- W1993043820 hasConcept C153911025 @default.
- W1993043820 hasConcept C175211621 @default.
- W1993043820 hasConcept C190727270 @default.
- W1993043820 hasConcept C203014093 @default.
- W1993043820 hasConcept C2779979206 @default.
- W1993043820 hasConcept C2780942790 @default.
- W1993043820 hasConcept C33288867 @default.
- W1993043820 hasConcept C41091548 @default.
- W1993043820 hasConcept C48023723 @default.
- W1993043820 hasConcept C502942594 @default.
- W1993043820 hasConcept C552990157 @default.
- W1993043820 hasConcept C553184892 @default.
- W1993043820 hasConcept C55493867 @default.