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- W1993051739 abstract "Rats were fed a low iodine diet with propylthiouracil added at a level of from 2×1O−5 to 15×lO−2%. In 2 of the 3 experiments, half the animals received supplementary iodine. In no instance was the thyroid enlargement in propylthiouracil-fed rats significantly greater than that of the respective controls without a concomitant lowering of radioiodine uptake. Iodine supplementation favored the formation of diiodotyrosine and T4 over monoiodotyrosine and T3. Propylthiouracil inhibited formation of diiodotyrosine and T4 to a greater extent than it did monoiodotyrosine and T3. Supplementary iodine decreased goitrogenesis but increased the inhibitory effects of propylthiouracil on radioiodine uptake and on formation of diiodotyrosine and T4." @default.
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- W1993051739 date "1962-05-01" @default.
- W1993051739 modified "2023-09-27" @default.
- W1993051739 title "Studies on the Production of High Radioiodine Uptake Goiter with Propylthiouracil" @default.
- W1993051739 doi "https://doi.org/10.1210/endo-70-5-650" @default.
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