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• W1993071510 abstract "Abstract The role of the major histocompatibility complex (MHC) in mate choice in humans is controversial. Nowadays, the availability of genetic variation data at genomic scales allows for a careful assessment of this question. In 2008, Chaix et al. reported evidence for MHC‐dependent mate choice among European American spouses from the HapMap 2 dataset. Recently, Derti et al. suggested that this observation was not robust. Furthermore, when Derti et al. applied similar analyses to the HapMap 3 European American samples, they did not see a significant effect. Although some of the points raised by Derti et al. are relevant, we disagree with the reported absence of evidence for MHC‐dependent mate choice within the HapMap samples. More precisely, we show here that the MHC dissimilarity among HapMap 3 European American spouses is still extreme in comparison to the rest of the genome, even after multiple testing correction. This finding supports the hypothesis of MHC‐dependent mate choice in some human populations." @default.
• W1993071510 created "2016-06-24" @default.
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• W1993071510 date "2012-02-16" @default.
• W1993071510 modified "2023-10-18" @default.
• W1993071510 title "MHC-dependent mate choice in humans: Why genomic patterns from the HapMap European American dataset support the hypothesis" @default.
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• W1993071510 doi "https://doi.org/10.1002/bies.201100150" @default.
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