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• W1993089905 abstract "Abstract Background Antidepressants promote neuronal structural plasticity in young-adult rodents, but little is known of their effects on older animals. The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) may mediate these structural changes through its anti-adhesive properties. PSA-NCAM is expressed in immature neurons and in a subpopulation of mature interneurons and its expression is modulated by antidepressants in the telencephalon of young-adult rodents. Results We have analyzed the effects of 14 days of fluoxetine treatment on the density of puncta expressing PSA-NCAM and different presynaptic markers in the medial prefrontal cortex, hippocampus and amygdala of middle-aged (8 months old) rats. The density of puncta expressing PSA-NCAM increased in the dorsal cingulate cortex, as well as in different hippocampal and amygdaloid regions. In these later regions there were also increases in the density of puncta expressing glutamic acid decarboxylase 65/67 (GAD6), synaptophysin (SYN), PSA-NCAM/SYN and PSA-NCAM/GAD6, but a decrease of those expressing vesicular glutamate transporter 1 (VGluT1). Since there is controversy on the effects of antidepressants on neurogenesis during aging, we analyzed the number of proliferating cells expressing Ki67 and that of immature neurons expressing doublecortin or PSA-NCAM. No significant changes were found in the subgranular zone, but the number of proliferating cells decreased in the subventricular zone. Conclusions These results indicate that the effects of fluoxetine in middle-aged rats are different to those previously described in young-adult animals, being more restricted in the mPFC and even following an opposite direction in the amygdala or the subventricular zone." @default.
• W1993089905 created "2016-06-24" @default.
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• W1993089905 date "2012-01-05" @default.
• W1993089905 modified "2023-10-17" @default.
• W1993089905 title "Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis" @default.
• W1993089905 cites W1491963713 @default.
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• W1993089905 cites W1963532283 @default.
• W1993089905 cites W1964814541 @default.
• W1993089905 cites W1965822810 @default.
• W1993089905 cites W1966023781 @default.
• W1993089905 cites W1967095650 @default.
• W1993089905 cites W1967913887 @default.
• W1993089905 cites W1974629262 @default.
• W1993089905 cites W1974776346 @default.
• W1993089905 cites W1977550486 @default.
• W1993089905 cites W1983706324 @default.
• W1993089905 cites W1985237413 @default.
• W1993089905 cites W1985244709 @default.
• W1993089905 cites W1986618663 @default.
• W1993089905 cites W1993191726 @default.
• W1993089905 cites W1996642120 @default.
• W1993089905 cites W1997901204 @default.
• W1993089905 cites W2003303130 @default.
• W1993089905 cites W2004019962 @default.
• W1993089905 cites W2005556413 @default.
• W1993089905 cites W2010757191 @default.
• W1993089905 cites W2013336473 @default.
• W1993089905 cites W2016166396 @default.
• W1993089905 cites W2016929792 @default.
• W1993089905 cites W2022221011 @default.
• W1993089905 cites W2025353122 @default.
• W1993089905 cites W2027262215 @default.
• W1993089905 cites W2028085044 @default.
• W1993089905 cites W2028443866 @default.
• W1993089905 cites W2029046909 @default.
• W1993089905 cites W2030571181 @default.
• W1993089905 cites W2030772288 @default.
• W1993089905 cites W2030868131 @default.
• W1993089905 cites W2041156404 @default.
• W1993089905 cites W2041794679 @default.
• W1993089905 cites W2042996394 @default.
• W1993089905 cites W2044137472 @default.
• W1993089905 cites W2051045604 @default.
• W1993089905 cites W2051081004 @default.
• W1993089905 cites W2051519442 @default.
• W1993089905 cites W2057566553 @default.
• W1993089905 cites W2058868956 @default.
• W1993089905 cites W2060420002 @default.
• W1993089905 cites W2061191067 @default.
• W1993089905 cites W2062254178 @default.
• W1993089905 cites W2062476270 @default.
• W1993089905 cites W2067477227 @default.
• W1993089905 cites W2071804866 @default.
• W1993089905 cites W2072268612 @default.
• W1993089905 cites W2072969178 @default.
• W1993089905 cites W2079014559 @default.
• W1993089905 cites W2082305818 @default.
• W1993089905 cites W2082596163 @default.
• W1993089905 cites W2089372771 @default.
• W1993089905 cites W2089776296 @default.
• W1993089905 cites W2093359958 @default.
• W1993089905 cites W2109636493 @default.
• W1993089905 cites W2122369103 @default.
• W1993089905 cites W2125517953 @default.
• W1993089905 cites W2127838460 @default.
• W1993089905 cites W2130065224 @default.
• W1993089905 cites W2133565799 @default.
• W1993089905 cites W2134083528 @default.
• W1993089905 cites W2141167930 @default.
• W1993089905 cites W2142002093 @default.
• W1993089905 cites W2146159594 @default.
• W1993089905 cites W2146504162 @default.
• W1993089905 cites W2148239264 @default.
• W1993089905 cites W2154841219 @default.
• W1993089905 cites W2160383565 @default.
• W1993089905 cites W2167179332 @default.
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• W1993089905 doi "https://doi.org/10.1186/1471-2202-13-5" @default.
• W1993089905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3278353" @default.
• W1993089905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22221403" @default.
• W1993089905 hasPublicationYear "2012" @default.
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