FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993094865> ?p ?o ?g. }

• W1993094865 endingPage "e24923" @default.
• W1993094865 startingPage "e24923" @default.
• W1993094865 abstract "Cytokine and growth factor signaling pathways involving STAT3 are frequently constitutively activated in many human primary tumors, and are known for the transcriptional role they play in controlling cell growth and cell cycle progression. However, the extent of STAT3's reach on transcriptional control of the genome as a whole remains an important question. We predicted that this persistent STAT3 signaling affects a wide variety of cellular functions, many of which still remain to be characterized. We took a broad approach to identify novel STAT3 regulated genes by examining changes in the genome-wide gene expression profile by microarray, using cells expressing constitutively-activated STAT3. Using computational analysis, we were able to define the gene expression profiles of cells containing activated STAT3 and identify candidate target genes with a wide range of biological functions. Among these genes we identified Necdin, a negative growth regulator, as a novel STAT3 target gene, whose expression is down-regulated at the mRNA and protein levels when STAT3 is constitutively active. This repression is STAT3 dependent, since inhibition of STAT3 using siRNA restores Necdin expression. A STAT3 DNA-binding site was identified in the Necdin promoter and both EMSA and chromatin immunoprecipitation confirm binding of STAT3 to this region. Necdin expression has previously been shown to be down-regulated in a melanoma and a drug-resistant ovarian cancer cell line. Further analysis of Necdin expression demonstrated repression in a STAT3-dependent manner in human melanoma, prostate and breast cancer cell lines. These results suggest that STAT3 coordinates expression of genes involved in multiple metabolic and biosynthetic pathways, integrating signals that lead to global transcriptional changes and oncogenesis. STAT3 may exert its oncogenic effect by up-regulating transcription of genes involved in promoting growth and proliferation, but also by down-regulating expression of negative regulators of the same cellular processes, such as Necdin." @default.
• W1993094865 created "2016-06-24" @default.
• W1993094865 creator A5010264712 @default.
• W1993094865 creator A5022795218 @default.
• W1993094865 creator A5026325794 @default.
• W1993094865 creator A5053258201 @default.
• W1993094865 creator A5063756425 @default.
• W1993094865 creator A5069870473 @default.
• W1993094865 creator A5088825137 @default.
• W1993094865 date "2011-10-27" @default.
• W1993094865 modified "2023-10-16" @default.
• W1993094865 title "Necdin, a Negative Growth Regulator, Is a Novel STAT3 Target Gene Down-Regulated in Human Cancer" @default.
• W1993094865 cites W1548640328 @default.
• W1993094865 cites W1550156431 @default.
• W1993094865 cites W1558123369 @default.
• W1993094865 cites W1605768520 @default.
• W1993094865 cites W1639450499 @default.
• W1993094865 cites W1821858011 @default.
• W1993094865 cites W1917630072 @default.
• W1993094865 cites W1936787907 @default.
• W1993094865 cites W1965878299 @default.
• W1993094865 cites W1966593231 @default.
• W1993094865 cites W1969512609 @default.
• W1993094865 cites W1977681992 @default.
• W1993094865 cites W1979216378 @default.
• W1993094865 cites W1980480652 @default.
• W1993094865 cites W1984539870 @default.
• W1993094865 cites W1988296630 @default.
• W1993094865 cites W1989220451 @default.
• W1993094865 cites W1990247827 @default.
• W1993094865 cites W1999468766 @default.
• W1993094865 cites W2002331964 @default.
• W1993094865 cites W2004150291 @default.
• W1993094865 cites W2007897471 @default.
• W1993094865 cites W2009177754 @default.
• W1993094865 cites W2011717936 @default.
• W1993094865 cites W2020259322 @default.
• W1993094865 cites W2024161072 @default.
• W1993094865 cites W2024282024 @default.
• W1993094865 cites W2024728491 @default.
• W1993094865 cites W2028617581 @default.
• W1993094865 cites W2029275361 @default.
• W1993094865 cites W2032674547 @default.
• W1993094865 cites W2044991100 @default.
• W1993094865 cites W2056961869 @default.
• W1993094865 cites W2057360439 @default.
• W1993094865 cites W2059566143 @default.
• W1993094865 cites W2061070237 @default.
• W1993094865 cites W2062084642 @default.
• W1993094865 cites W2062222985 @default.
• W1993094865 cites W2069311674 @default.
• W1993094865 cites W2070217465 @default.
• W1993094865 cites W2071516626 @default.
• W1993094865 cites W2071671690 @default.
• W1993094865 cites W2072493113 @default.
• W1993094865 cites W2074356752 @default.
• W1993094865 cites W2076716879 @default.
• W1993094865 cites W2083802827 @default.
• W1993094865 cites W2087897472 @default.
• W1993094865 cites W2088179569 @default.
• W1993094865 cites W2088357471 @default.
• W1993094865 cites W2108814365 @default.
• W1993094865 cites W2114445658 @default.
• W1993094865 cites W2115744231 @default.
• W1993094865 cites W2116401711 @default.
• W1993094865 cites W2118310862 @default.
• W1993094865 cites W2122456293 @default.
• W1993094865 cites W2122683221 @default.
• W1993094865 cites W2124043243 @default.
• W1993094865 cites W2134661616 @default.
• W1993094865 cites W2157795344 @default.
• W1993094865 cites W2158217645 @default.
• W1993094865 cites W2159730182 @default.
• W1993094865 cites W2160770127 @default.
• W1993094865 cites W2167646860 @default.
• W1993094865 cites W2170090299 @default.
• W1993094865 cites W2170989872 @default.
• W1993094865 cites W2330829715 @default.
• W1993094865 cites W4294107304 @default.
• W1993094865 cites W4383058088 @default.
• W1993094865 doi "https://doi.org/10.1371/journal.pone.0024923" @default.
• W1993094865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3203112" @default.
• W1993094865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22046235" @default.
• W1993094865 hasPublicationYear "2011" @default.
• W1993094865 type Work @default.
• W1993094865 sameAs 1993094865 @default.
• W1993094865 citedByCount "18" @default.
• W1993094865 countsByYear W19930948652012 @default.
• W1993094865 countsByYear W19930948652013 @default.
• W1993094865 countsByYear W19930948652014 @default.
• W1993094865 countsByYear W19930948652015 @default.
• W1993094865 countsByYear W19930948652016 @default.
• W1993094865 countsByYear W19930948652018 @default.
• W1993094865 countsByYear W19930948652021 @default.
• W1993094865 countsByYear W19930948652022 @default.
• W1993094865 crossrefType "journal-article" @default.
• W1993094865 hasAuthorship W1993094865A5010264712 @default.
• W1993094865 hasAuthorship W1993094865A5022795218 @default.

• next