FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993102708> ?p ?o ?g. }

• W1993102708 endingPage "457" @default.
• W1993102708 startingPage "448" @default.
• W1993102708 abstract "CXCL14, a member of chemokine family, was previously known to participate in many pathophysiological events, such as leukocytes recruitment and tumor suppression. However, it remained largely unknown whether CXCL14 is a physiological player during early pregnancy. In this regard, our recent global gene microarray analysis has observed an implantation-specific expression profile of CXCL14 mRNA during early pregnancy in mice, showing its higher levels at implantation sites compared to inter-implantation sites, implicating a potential role of CXCL14 in the periimplantation events. In the present investigation, using Northern blot, in situ hybridization and immunostaining, we further demonstrated that uterine CXCL14 expression was specifically induced at embryo implantation site and expanded with subsequent decidualization process in a spatiotemporal manner. The implanting embryo also showed a highlighted expression of CXCL14 in the blastocyst trophectoderm and its derived ectoplacental cones (EPCs) during postimplantation development. In vitro functional study revealed that CXCL14 could significantly inhibit both primary and secondary trophoblast attachment and outgrowth, correlated with a stage-dependant downregulation of MMP-2 and/or MMP-9 activity. Moreover, it was found that biotinylated CXCL14 could specifically bind to trophoblast cells in vitro and in vivo, suggesting trophoblast cell, perhaps expressing the unidentified CXCL14 receptor, is a bioactive target of CXCL14. Collectively, our findings provide evidences supporting the contention that CXCL14 is an important paracrine/autocrine modulator regulating trophoblast outgrowth at the maternal-fetal interface during the process of pregnancy establishment. This study is clinically related since CXCL14 is also highly expressed in human receptive endometrium and trophoblasts." @default.
• W1993102708 created "2016-06-24" @default.
• W1993102708 creator A5016034217 @default.
• W1993102708 creator A5025175329 @default.
• W1993102708 creator A5042973046 @default.
• W1993102708 creator A5047645060 @default.
• W1993102708 creator A5053029021 @default.
• W1993102708 creator A5053263581 @default.
• W1993102708 creator A5066716873 @default.
• W1993102708 creator A5067335142 @default.
• W1993102708 date "2009-07-22" @default.
• W1993102708 modified "2023-10-01" @default.
• W1993102708 title "CXCL14 inhibits trophoblast outgrowth via a paracrine/autocrine manner during early pregnancy in mice" @default.
• W1993102708 cites W1540238567 @default.
• W1993102708 cites W1575333294 @default.
• W1993102708 cites W1649213427 @default.
• W1993102708 cites W1970219684 @default.
• W1993102708 cites W1973951521 @default.
• W1993102708 cites W1982671249 @default.
• W1993102708 cites W1989445180 @default.
• W1993102708 cites W1990498979 @default.
• W1993102708 cites W2009505821 @default.
• W1993102708 cites W2030384822 @default.
• W1993102708 cites W2043267841 @default.
• W1993102708 cites W2048007521 @default.
• W1993102708 cites W2055133425 @default.
• W1993102708 cites W2056568186 @default.
• W1993102708 cites W2061018632 @default.
• W1993102708 cites W2063591322 @default.
• W1993102708 cites W2081211027 @default.
• W1993102708 cites W2093060517 @default.
• W1993102708 cites W2100963977 @default.
• W1993102708 cites W2104918497 @default.
• W1993102708 cites W2105446185 @default.
• W1993102708 cites W2107797512 @default.
• W1993102708 cites W2111432660 @default.
• W1993102708 cites W2120360916 @default.
• W1993102708 cites W2121952176 @default.
• W1993102708 cites W2124717097 @default.
• W1993102708 cites W2125686203 @default.
• W1993102708 cites W2132798799 @default.
• W1993102708 cites W2133192035 @default.
• W1993102708 cites W2135421977 @default.
• W1993102708 cites W2140641560 @default.
• W1993102708 cites W2141698984 @default.
• W1993102708 cites W2150365936 @default.
• W1993102708 cites W2157674060 @default.
• W1993102708 cites W2158472102 @default.
• W1993102708 cites W2164002837 @default.
• W1993102708 cites W2165261531 @default.
• W1993102708 cites W2325674170 @default.
• W1993102708 doi "https://doi.org/10.1002/jcp.21877" @default.
• W1993102708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19626669" @default.
• W1993102708 hasPublicationYear "2009" @default.
• W1993102708 type Work @default.
• W1993102708 sameAs 1993102708 @default.
• W1993102708 citedByCount "29" @default.
• W1993102708 countsByYear W19931027082012 @default.
• W1993102708 countsByYear W19931027082015 @default.
• W1993102708 countsByYear W19931027082016 @default.
• W1993102708 countsByYear W19931027082017 @default.
• W1993102708 countsByYear W19931027082019 @default.
• W1993102708 countsByYear W19931027082020 @default.
• W1993102708 countsByYear W19931027082021 @default.
• W1993102708 countsByYear W19931027082022 @default.
• W1993102708 crossrefType "journal-article" @default.
• W1993102708 hasAuthorship W1993102708A5016034217 @default.
• W1993102708 hasAuthorship W1993102708A5025175329 @default.
• W1993102708 hasAuthorship W1993102708A5042973046 @default.
• W1993102708 hasAuthorship W1993102708A5047645060 @default.
• W1993102708 hasAuthorship W1993102708A5053029021 @default.
• W1993102708 hasAuthorship W1993102708A5053263581 @default.
• W1993102708 hasAuthorship W1993102708A5066716873 @default.
• W1993102708 hasAuthorship W1993102708A5067335142 @default.
• W1993102708 hasConcept C12823836 @default.
• W1993102708 hasConcept C128240485 @default.
• W1993102708 hasConcept C13373296 @default.
• W1993102708 hasConcept C134018914 @default.
• W1993102708 hasConcept C16685009 @default.
• W1993102708 hasConcept C170493617 @default.
• W1993102708 hasConcept C172680121 @default.
• W1993102708 hasConcept C196843134 @default.
• W1993102708 hasConcept C2776953305 @default.
• W1993102708 hasConcept C2777495146 @default.
• W1993102708 hasConcept C2778177303 @default.
• W1993102708 hasConcept C2778316770 @default.
• W1993102708 hasConcept C2779234561 @default.
• W1993102708 hasConcept C2779742232 @default.
• W1993102708 hasConcept C45167389 @default.
• W1993102708 hasConcept C45240729 @default.
• W1993102708 hasConcept C54355233 @default.
• W1993102708 hasConcept C71924100 @default.
• W1993102708 hasConcept C7876069 @default.
• W1993102708 hasConcept C86803240 @default.
• W1993102708 hasConcept C87073359 @default.
• W1993102708 hasConcept C95444343 @default.
• W1993102708 hasConceptScore W1993102708C12823836 @default.
• W1993102708 hasConceptScore W1993102708C128240485 @default.

• next