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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993109766> ?p ?o ?g. }

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• W1993109766 abstract "Twenty compounds selected as representative members of three series of long-chain 1,2-diamines, 2-amino-1-alkanols and 1-amino-2-alkanols structurally related to dihydrosphingosin, were synthesized and tested in vitro for their ability to inhibit the sleeping sickness parasites Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Eight compounds showed EC50 values in the submicromolar range, with selectivity indexes up to 39 related to the respective cytotoxicity values for Vero cells. The parasite phenotype detected after treatment with the most potent compounds showed irreversible cell morphology alterations of the flagellar pocket that lead to inhibition of cell growth and parasite death." @default.
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• W1993109766 date "2012-01-01" @default.
• W1993109766 modified "2023-10-02" @default.
• W1993109766 title "Diamine and aminoalcohol derivatives active against Trypanosoma brucei" @default.
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• W1993109766 doi "https://doi.org/10.1016/j.bmcl.2011.10.108" @default.
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