FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993113186> ?p ?o ?g. }

• W1993113186 endingPage "826" @default.
• W1993113186 startingPage "817" @default.
• W1993113186 abstract "Sympathetic vasoconstriction is attenuated by metabolic events in contracting rat skeletal muscle, in part by activation of ATP‐sensitive potassium (K ATP ) channels. However, the specific metabolites in contracting muscle that open K ATP channels are not known. We therefore asked if contraction‐induced attenuation of sympathetic vasoconstriction is mediated by the endogenous vasodilators nitric oxide (NO), adenosine, or prostaglandins PGI 2 or PGE 2 , all of which are putative K ATP channel openers. In anaesthetized rats, hindlimb contraction alone significantly attenuated the vasoconstrictor responses to lumbar sympathetic nerve stimulation. Inhibition of NO synthase with N ‐nitro‐L‐arginine methyl ester (L‐NAME, 5 mg kg −1 , i.v.) partially reversed this effect of contraction, resulting in enhanced sympathetic vasoconstriction in contracting hindlimb. Subsequent treatment with the K ATP channel blocker glibenclamide (20 mg kg −1 , i.v.) had no further effect on sympathetic vasoconstriction in contracting hindlimb. This effect of L‐NAME to partially reverse contraction‐induced attenuation of sympathetic vasoconstriction was not replicated by D‐NAME (5 mg kg −1 , i.v.) or angiotensin II (12.5 ng kg −1 min −1 , i.v.), the latter used as a hypertensive control. Adenosine receptor blockade with 8‐( p ‐sulphophenyl)theophylline (10 mg kg −1 , i.v.) or cyclooxygenase inhibition with indomethacin (5 mg kg −1 , i.v.) had no effect on contraction‐induced attenuation of sympathetic vasoconstriction. These results suggest that NO plays an important role in the precise regulation of blood flow in exercising skeletal muscles by opposing sympathetic vasoconstriction. Although the underlying mechanism is not known, it may involve NO‐induced activation of vascular K ATP channels." @default.
• W1993113186 created "2016-06-24" @default.
• W1993113186 creator A5011058208 @default.
• W1993113186 creator A5011335360 @default.
• W1993113186 date "1998-02-01" @default.
• W1993113186 modified "2023-10-15" @default.
• W1993113186 title "Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle" @default.
• W1993113186 cites W1795275022 @default.
• W1993113186 cites W1800235608 @default.
• W1993113186 cites W1837367668 @default.
• W1993113186 cites W1969764912 @default.
• W1993113186 cites W1978104136 @default.
• W1993113186 cites W1981549053 @default.
• W1993113186 cites W2010469212 @default.
• W1993113186 cites W2022021204 @default.
• W1993113186 cites W2032702492 @default.
• W1993113186 cites W2042054187 @default.
• W1993113186 cites W2054558538 @default.
• W1993113186 cites W2059155059 @default.
• W1993113186 cites W2064620945 @default.
• W1993113186 cites W2067414024 @default.
• W1993113186 cites W2073710276 @default.
• W1993113186 cites W2077528102 @default.
• W1993113186 cites W2086823174 @default.
• W1993113186 cites W2090968114 @default.
• W1993113186 cites W2092928881 @default.
• W1993113186 cites W2100750557 @default.
• W1993113186 cites W2113079538 @default.
• W1993113186 cites W2113769239 @default.
• W1993113186 cites W2115537698 @default.
• W1993113186 cites W2127846112 @default.
• W1993113186 cites W2132580447 @default.
• W1993113186 cites W2133421622 @default.
• W1993113186 cites W2137114742 @default.
• W1993113186 cites W2146301720 @default.
• W1993113186 cites W2154239903 @default.
• W1993113186 cites W2163393286 @default.
• W1993113186 cites W2180338224 @default.
• W1993113186 cites W2209062459 @default.
• W1993113186 cites W2243722387 @default.
• W1993113186 cites W2253802262 @default.
• W1993113186 cites W2277288131 @default.
• W1993113186 cites W2311393071 @default.
• W1993113186 cites W2333859762 @default.
• W1993113186 cites W2411321651 @default.
• W1993113186 cites W2425827454 @default.
• W1993113186 cites W2746027690 @default.
• W1993113186 doi "https://doi.org/10.1111/j.1469-7793.1998.817bv.x" @default.
• W1993113186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2230749" @default.
• W1993113186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9503340" @default.
• W1993113186 hasPublicationYear "1998" @default.
• W1993113186 type Work @default.
• W1993113186 sameAs 1993113186 @default.
• W1993113186 citedByCount "231" @default.
• W1993113186 countsByYear W19931131862012 @default.
• W1993113186 countsByYear W19931131862013 @default.
• W1993113186 countsByYear W19931131862014 @default.
• W1993113186 countsByYear W19931131862015 @default.
• W1993113186 countsByYear W19931131862016 @default.
• W1993113186 countsByYear W19931131862017 @default.
• W1993113186 countsByYear W19931131862018 @default.
• W1993113186 countsByYear W19931131862019 @default.
• W1993113186 countsByYear W19931131862020 @default.
• W1993113186 countsByYear W19931131862021 @default.
• W1993113186 countsByYear W19931131862022 @default.
• W1993113186 countsByYear W19931131862023 @default.
• W1993113186 crossrefType "journal-article" @default.
• W1993113186 hasAuthorship W1993113186A5011058208 @default.
• W1993113186 hasAuthorship W1993113186A5011335360 @default.
• W1993113186 hasBestOaLocation W19931131862 @default.
• W1993113186 hasConcept C120770815 @default.
• W1993113186 hasConcept C126322002 @default.
• W1993113186 hasConcept C134018914 @default.
• W1993113186 hasConcept C163415756 @default.
• W1993113186 hasConcept C185592680 @default.
• W1993113186 hasConcept C2777622882 @default.
• W1993113186 hasConcept C2779395532 @default.
• W1993113186 hasConcept C2779961880 @default.
• W1993113186 hasConcept C2992686903 @default.
• W1993113186 hasConcept C519581460 @default.
• W1993113186 hasConcept C71924100 @default.
• W1993113186 hasConceptScore W1993113186C120770815 @default.
• W1993113186 hasConceptScore W1993113186C126322002 @default.
• W1993113186 hasConceptScore W1993113186C134018914 @default.
• W1993113186 hasConceptScore W1993113186C163415756 @default.
• W1993113186 hasConceptScore W1993113186C185592680 @default.
• W1993113186 hasConceptScore W1993113186C2777622882 @default.
• W1993113186 hasConceptScore W1993113186C2779395532 @default.
• W1993113186 hasConceptScore W1993113186C2779961880 @default.
• W1993113186 hasConceptScore W1993113186C2992686903 @default.
• W1993113186 hasConceptScore W1993113186C519581460 @default.
• W1993113186 hasConceptScore W1993113186C71924100 @default.
• W1993113186 hasIssue "3" @default.
• W1993113186 hasLocation W19931131861 @default.
• W1993113186 hasLocation W19931131862 @default.
• W1993113186 hasLocation W19931131863 @default.
• W1993113186 hasOpenAccess W1993113186 @default.
• W1993113186 hasPrimaryLocation W19931131861 @default.

• next