Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993120900> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1993120900 abstract "Abstract The administration of acetate or sulfanilamide depressed the porphyric response of rats to 3,5-dicarbethoxy-1,4-dihydrocollidine. The induction of δ-aminolevulinate synthetase (EC 2.3.1.37) in porphyric rats was decreased by acetate administration and δ-aminolevulinate synthetase activity in hepatic homogenates was inhibited by acetate. Succinate reversed the inhibition by acetate in vitro . Since an alteration of heme biosynthesis by acetate was observed, the effect of acetate on the induction of hepatic microsomal cytochrome P -450 and microsomal mixed-function oxidase by phenobarbital was examined. Acetate prevented the induction of hepatic mixed-function oxidase and cytochrome P -450 by phenobarbital. Unlike the action of other inhibitors of hepatic heme biosynthesis, acetate also prevented the induction by phenobarbital of NADPH-cytochrome c reductase (EC 1.6.99.3). These findings suggest that acetate may be inhibiting heme biosynthesis by effects on δ-aminolevulinate synthetase, the rate-limiting step in heme biosynthesis, by alteration of the induction of this enzyme and by a direct effect on the enzymic reaction itself. It is suggested that acetate may be involved in the glucose effect related to the inhibition of the induction of δ-aminolevulinate synthetase." @default.
- W1993120900 created "2016-06-24" @default.
- W1993120900 creator A5002630064 @default.
- W1993120900 creator A5022401835 @default.
- W1993120900 date "1974-09-01" @default.
- W1993120900 modified "2023-09-27" @default.
- W1993120900 title "The reversal of experimental porphyria and the prevention of induction of hepatic mixed-function oxidase by acetate" @default.
- W1993120900 cites W1564577776 @default.
- W1993120900 cites W1665143716 @default.
- W1993120900 cites W1775749144 @default.
- W1993120900 cites W1964479613 @default.
- W1993120900 cites W2006300374 @default.
- W1993120900 cites W2037930016 @default.
- W1993120900 cites W2059366048 @default.
- W1993120900 cites W2090094658 @default.
- W1993120900 doi "https://doi.org/10.1016/0003-9861(74)90041-1" @default.
- W1993120900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4372951" @default.
- W1993120900 hasPublicationYear "1974" @default.
- W1993120900 type Work @default.
- W1993120900 sameAs 1993120900 @default.
- W1993120900 citedByCount "8" @default.
- W1993120900 countsByYear W19931209002019 @default.
- W1993120900 crossrefType "journal-article" @default.
- W1993120900 hasAuthorship W1993120900A5002630064 @default.
- W1993120900 hasAuthorship W1993120900A5022401835 @default.
- W1993120900 hasConcept C132154277 @default.
- W1993120900 hasConcept C134018914 @default.
- W1993120900 hasConcept C181199279 @default.
- W1993120900 hasConcept C185592680 @default.
- W1993120900 hasConcept C2776217839 @default.
- W1993120900 hasConcept C2777940757 @default.
- W1993120900 hasConcept C2778793413 @default.
- W1993120900 hasConcept C2780768313 @default.
- W1993120900 hasConcept C38485361 @default.
- W1993120900 hasConcept C553450214 @default.
- W1993120900 hasConcept C55493867 @default.
- W1993120900 hasConcept C86803240 @default.
- W1993120900 hasConcept C87644729 @default.
- W1993120900 hasConceptScore W1993120900C132154277 @default.
- W1993120900 hasConceptScore W1993120900C134018914 @default.
- W1993120900 hasConceptScore W1993120900C181199279 @default.
- W1993120900 hasConceptScore W1993120900C185592680 @default.
- W1993120900 hasConceptScore W1993120900C2776217839 @default.
- W1993120900 hasConceptScore W1993120900C2777940757 @default.
- W1993120900 hasConceptScore W1993120900C2778793413 @default.
- W1993120900 hasConceptScore W1993120900C2780768313 @default.
- W1993120900 hasConceptScore W1993120900C38485361 @default.
- W1993120900 hasConceptScore W1993120900C553450214 @default.
- W1993120900 hasConceptScore W1993120900C55493867 @default.
- W1993120900 hasConceptScore W1993120900C86803240 @default.
- W1993120900 hasConceptScore W1993120900C87644729 @default.
- W1993120900 hasLocation W19931209001 @default.
- W1993120900 hasLocation W19931209002 @default.
- W1993120900 hasOpenAccess W1993120900 @default.
- W1993120900 hasPrimaryLocation W19931209001 @default.
- W1993120900 hasRelatedWork W1793979483 @default.
- W1993120900 hasRelatedWork W2019730007 @default.
- W1993120900 hasRelatedWork W2033434649 @default.
- W1993120900 hasRelatedWork W2037670419 @default.
- W1993120900 hasRelatedWork W2059522525 @default.
- W1993120900 hasRelatedWork W2062055751 @default.
- W1993120900 hasRelatedWork W2118376642 @default.
- W1993120900 hasRelatedWork W2411360883 @default.
- W1993120900 hasRelatedWork W2413208464 @default.
- W1993120900 hasRelatedWork W4250989885 @default.
- W1993120900 isParatext "false" @default.
- W1993120900 isRetracted "false" @default.
- W1993120900 magId "1993120900" @default.
- W1993120900 workType "article" @default.