FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993123841> ?p ?o ?g. }

• W1993123841 abstract "Fibroblast growth factor (FGF) 23 is one of the most recently discovered FGFs. This phosphaturic hormone produced in bones is a risk factor for cardiovascular diseases and thus mortality. Klotho is an essential coreceptor for FGF23 and at the same time it is known as a longevity hormone. There are no data considering FGF23 and Klotho roles in heart transplant (HT) recipients. The aim of this study was to assess Klotho and FGF23 serum concentration in heart transplant recipients depending on immunosuppressive therapy regimen and comorbidities.Eighty-four stable heart transplant recipients were enrolled in the study; 22 healthy volunteers served as control subjects. FGF23 and Klotho protein concentration, markers of renal function, such as cystatin C and neutrophil gelatinase-associated lipocalin (NGAL), and heart failure markers, such as copeptine and N-termiinal pro-B-type natriuretic peptide (NT-proBNP), were evaluated.FGF23 concentration was significantly higher in the HT group whereas Klotho protein was significantly lower. FGF23 correlated with creatinine level (r = 0.72; P < .001), estimated glomerular filtration rate (eGFR; r = -0.32; P < .01), cystatin C (r = 0.36; P < .01), NGAL (r = 0.51; P < .001), hemoglobin (r = -0.39; P < .001), NT-proBNP (r = 0.51; P < .001), high-density lipoprotein (HDL; r = 0.27; P < .05), intraventricular septum thickness (r = 0.42; P < .01) and right ventricular systolic pressure (r = 0.34; P < .05). Klotho protein correlated only with age (r = -0.21; P < .05), creatinine (r = -0.21; P < .05), and eGFR (r = -0.31; P < .01). FGF23 concentration was significantly higher in patients with eGFR <60 mL/min whereas Klotho protein was significantly lower. FGF23 predictors were renal function (creatinine concentration; β = 0.45; P = .0001), HDL (β = 0.33; P = .003), intraventricular septum thickness (β = 0.38; P = .0003), and right ventricular systolic pressure (β = 0.34; P = .003), explaining 70% of FGF23 variability.FGF23/Klotho system disorders in HT recipients are related to cardiovascular system function and kidney failure and could cause increased risk of cardiovascular disease." @default.
• W1993123841 created "2016-06-24" @default.
• W1993123841 creator A5002371458 @default.
• W1993123841 creator A5013643613 @default.
• W1993123841 creator A5046856007 @default.
• W1993123841 creator A5075740190 @default.
• W1993123841 creator A5078572020 @default.
• W1993123841 creator A5085303822 @default.
• W1993123841 date "2014-10-01" @default.
• W1993123841 modified "2023-09-27" @default.
• W1993123841 title "Fibroblast Growth Factor 23 and Klotho as Cardiovascular Risk Factors in Heart Transplant Recipients" @default.
• W1993123841 cites W1550111394 @default.
• W1993123841 cites W1803609188 @default.
• W1993123841 cites W1967918805 @default.
• W1993123841 cites W1976544899 @default.
• W1993123841 cites W1977645780 @default.
• W1993123841 cites W1988032328 @default.
• W1993123841 cites W2015668150 @default.
• W1993123841 cites W2025952915 @default.
• W1993123841 cites W2060108666 @default.
• W1993123841 cites W2120129493 @default.
• W1993123841 cites W2129321769 @default.
• W1993123841 cites W2147716913 @default.
• W1993123841 cites W2152523414 @default.
• W1993123841 cites W2155965977 @default.
• W1993123841 cites W2157448600 @default.
• W1993123841 cites W2162615269 @default.
• W1993123841 cites W2487377689 @default.
• W1993123841 cites W2525239864 @default.
• W1993123841 doi "https://doi.org/10.1016/j.transproceed.2014.09.039" @default.
• W1993123841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25380933" @default.
• W1993123841 hasPublicationYear "2014" @default.
• W1993123841 type Work @default.
• W1993123841 sameAs 1993123841 @default.
• W1993123841 citedByCount "6" @default.
• W1993123841 countsByYear W19931238412016 @default.
• W1993123841 countsByYear W19931238412017 @default.
• W1993123841 countsByYear W19931238412019 @default.
• W1993123841 countsByYear W19931238412020 @default.
• W1993123841 crossrefType "journal-article" @default.
• W1993123841 hasAuthorship W1993123841A5002371458 @default.
• W1993123841 hasAuthorship W1993123841A5013643613 @default.
• W1993123841 hasAuthorship W1993123841A5046856007 @default.
• W1993123841 hasAuthorship W1993123841A5075740190 @default.
• W1993123841 hasAuthorship W1993123841A5078572020 @default.
• W1993123841 hasAuthorship W1993123841A5085303822 @default.
• W1993123841 hasConcept C114276007 @default.
• W1993123841 hasConcept C126322002 @default.
• W1993123841 hasConcept C134018914 @default.
• W1993123841 hasConcept C159641895 @default.
• W1993123841 hasConcept C170493617 @default.
• W1993123841 hasConcept C2775915353 @default.
• W1993123841 hasConcept C2778198053 @default.
• W1993123841 hasConcept C2779548226 @default.
• W1993123841 hasConcept C2780091579 @default.
• W1993123841 hasConcept C2781208988 @default.
• W1993123841 hasConcept C50440223 @default.
• W1993123841 hasConcept C519063684 @default.
• W1993123841 hasConcept C71924100 @default.
• W1993123841 hasConcept C74373430 @default.
• W1993123841 hasConcept C9832595 @default.
• W1993123841 hasConceptScore W1993123841C114276007 @default.
• W1993123841 hasConceptScore W1993123841C126322002 @default.
• W1993123841 hasConceptScore W1993123841C134018914 @default.
• W1993123841 hasConceptScore W1993123841C159641895 @default.
• W1993123841 hasConceptScore W1993123841C170493617 @default.
• W1993123841 hasConceptScore W1993123841C2775915353 @default.
• W1993123841 hasConceptScore W1993123841C2778198053 @default.
• W1993123841 hasConceptScore W1993123841C2779548226 @default.
• W1993123841 hasConceptScore W1993123841C2780091579 @default.
• W1993123841 hasConceptScore W1993123841C2781208988 @default.
• W1993123841 hasConceptScore W1993123841C50440223 @default.
• W1993123841 hasConceptScore W1993123841C519063684 @default.
• W1993123841 hasConceptScore W1993123841C71924100 @default.
• W1993123841 hasConceptScore W1993123841C74373430 @default.
• W1993123841 hasConceptScore W1993123841C9832595 @default.
• W1993123841 hasLocation W19931238411 @default.
• W1993123841 hasLocation W19931238412 @default.
• W1993123841 hasOpenAccess W1993123841 @default.
• W1993123841 hasPrimaryLocation W19931238411 @default.
• W1993123841 hasRelatedWork W1866926151 @default.
• W1993123841 hasRelatedWork W2010011920 @default.
• W1993123841 hasRelatedWork W2034177879 @default.
• W1993123841 hasRelatedWork W204922768 @default.
• W1993123841 hasRelatedWork W2076466637 @default.
• W1993123841 hasRelatedWork W2083050077 @default.
• W1993123841 hasRelatedWork W2093888290 @default.
• W1993123841 hasRelatedWork W2094039997 @default.
• W1993123841 hasRelatedWork W2098073856 @default.
• W1993123841 hasRelatedWork W2336391244 @default.
• W1993123841 hasRelatedWork W2427904904 @default.
• W1993123841 hasRelatedWork W2643806150 @default.
• W1993123841 hasRelatedWork W2772308797 @default.
• W1993123841 hasRelatedWork W2803682588 @default.
• W1993123841 hasRelatedWork W2803829870 @default.
• W1993123841 hasRelatedWork W2923097976 @default.
• W1993123841 hasRelatedWork W2938313062 @default.
• W1993123841 hasRelatedWork W3034015003 @default.
• W1993123841 hasRelatedWork W3041303237 @default.
• W1993123841 hasRelatedWork W3047661303 @default.

• next