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- W1993124600 endingPage "1128" @default.
- W1993124600 startingPage "1107" @default.
- W1993124600 abstract "Introduction: Microwave and continuous flow microreactors have become mainstream heating sources in contemporary pharmaceutical company laboratories. Such technologies will continue to benefit from design and engineering improvements, and now play a key role in the drug discovery process. Areas covered: The authors review the applications of flow- and microwave-mediated heating in library, combinatorial, solid-phase, metal-assisted, and protein chemistries. Additionally, the authors provide a description of the combination of microwave and continuous flow platforms, with applications in the preparation of radiopharmaceuticals and in drug candidate development. Literature reviewed is chiefly 2000 – 2012, plus key citations from earlier reports. Expert opinion: With the advent of microwave irradiation, reactions that normally took days to complete can now be performed in a matter of minutes. Coupled with the introduction of continuous flow microreactors, pharmaceutical companies have an easy way to improve the greenness and efficiency of many synthetic operations. The combined force of these technologies offers the potential to revolutionize discovery and manufacturing processes." @default.
- W1993124600 created "2016-06-24" @default.
- W1993124600 creator A5000635366 @default.
- W1993124600 creator A5012261183 @default.
- W1993124600 creator A5072679205 @default.
- W1993124600 date "2012-09-24" @default.
- W1993124600 modified "2023-09-25" @default.
- W1993124600 title "Microwave and continuous flow technologies in drug discovery" @default.
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