FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993128166> ?p ?o ?g. }

• W1993128166 endingPage "19883" @default.
• W1993128166 startingPage "19878" @default.
• W1993128166 abstract "Meiotic chromosome segregation involves pairing and segregation of homologous chromosomes in the first division and segregation of sister chromatids in the second division. Although it is known that the centromere and kinetochore are responsible for chromosome movement in meiosis as in mitosis, potential specialized meiotic functions are being uncovered. Centromere pairing early in meiosis I, even between nonhomologous chromosomes, and clustering of centromeres can promote proper homolog associations in meiosis I in yeast, plants, and Drosophila. It was not known, however, whether centromere proteins are required for this clustering. We exploited Drosophila mutants for the centromere proteins centromere protein-C (CENP-C) and chromosome alignment 1 (CAL1) to demonstrate that a functional centromere is needed for centromere clustering and pairing. The cenp-C and cal1 mutations result in C-terminal truncations, removing the domains through which these two proteins interact. The mutants show striking genetic interactions, failing to complement as double heterozygotes, resulting in disrupted centromere clustering and meiotic nondisjunction. The cluster of meiotic centromeres localizes to the nucleolus, and this association requires centromere function. In Drosophila, synaptonemal complex (SC) formation can initiate from the centromere, and the SC is retained at the centromere after it disassembles from the chromosome arms. Although functional CENP-C and CAL1 are dispensable for assembly of the SC, they are required for subsequent retention of the SC at the centromere. These results show that integral centromere proteins are required for nuclear position and intercentromere associations in meiosis." @default.
• W1993128166 created "2016-06-24" @default.
• W1993128166 creator A5018864319 @default.
• W1993128166 creator A5034360567 @default.
• W1993128166 date "2013-11-18" @default.
• W1993128166 modified "2023-10-13" @default.
• W1993128166 title "Centromere proteins CENP-C and CAL1 functionally interact in meiosis for centromere clustering, pairing, and chromosome segregation" @default.
• W1993128166 cites W1865573391 @default.
• W1993128166 cites W1967249732 @default.
• W1993128166 cites W1972784371 @default.
• W1993128166 cites W1977508050 @default.
• W1993128166 cites W1980179971 @default.
• W1993128166 cites W1983356538 @default.
• W1993128166 cites W1988762781 @default.
• W1993128166 cites W1991119887 @default.
• W1993128166 cites W2002402022 @default.
• W1993128166 cites W2003629404 @default.
• W1993128166 cites W2004910827 @default.
• W1993128166 cites W2005654623 @default.
• W1993128166 cites W2007645732 @default.
• W1993128166 cites W2013936241 @default.
• W1993128166 cites W2018057088 @default.
• W1993128166 cites W2020233047 @default.
• W1993128166 cites W2023980699 @default.
• W1993128166 cites W2024133477 @default.
• W1993128166 cites W2033797646 @default.
• W1993128166 cites W2034482404 @default.
• W1993128166 cites W2037149555 @default.
• W1993128166 cites W2039055983 @default.
• W1993128166 cites W2040867342 @default.
• W1993128166 cites W2042746313 @default.
• W1993128166 cites W2043516673 @default.
• W1993128166 cites W2048607858 @default.
• W1993128166 cites W2054928611 @default.
• W1993128166 cites W2056604483 @default.
• W1993128166 cites W2063017153 @default.
• W1993128166 cites W2067918695 @default.
• W1993128166 cites W2076095878 @default.
• W1993128166 cites W2076173602 @default.
• W1993128166 cites W2076627841 @default.
• W1993128166 cites W2077360297 @default.
• W1993128166 cites W2086575042 @default.
• W1993128166 cites W2087985833 @default.
• W1993128166 cites W2102032416 @default.
• W1993128166 cites W2111481274 @default.
• W1993128166 cites W2118117928 @default.
• W1993128166 cites W2118806304 @default.
• W1993128166 cites W2120782923 @default.
• W1993128166 cites W2124670713 @default.
• W1993128166 cites W2128588592 @default.
• W1993128166 cites W2132339860 @default.
• W1993128166 cites W2144681426 @default.
• W1993128166 cites W2154044359 @default.
• W1993128166 doi "https://doi.org/10.1073/pnas.1320074110" @default.
• W1993128166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3856785" @default.
• W1993128166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24248385" @default.
• W1993128166 hasPublicationYear "2013" @default.
• W1993128166 type Work @default.
• W1993128166 sameAs 1993128166 @default.
• W1993128166 citedByCount "25" @default.
• W1993128166 countsByYear W19931281662014 @default.
• W1993128166 countsByYear W19931281662015 @default.
• W1993128166 countsByYear W19931281662016 @default.
• W1993128166 countsByYear W19931281662017 @default.
• W1993128166 countsByYear W19931281662018 @default.
• W1993128166 countsByYear W19931281662019 @default.
• W1993128166 countsByYear W19931281662020 @default.
• W1993128166 countsByYear W19931281662021 @default.
• W1993128166 countsByYear W19931281662022 @default.
• W1993128166 countsByYear W19931281662023 @default.
• W1993128166 crossrefType "journal-article" @default.
• W1993128166 hasAuthorship W1993128166A5018864319 @default.
• W1993128166 hasAuthorship W1993128166A5034360567 @default.
• W1993128166 hasBestOaLocation W19931281661 @default.
• W1993128166 hasConcept C104317684 @default.
• W1993128166 hasConcept C148196450 @default.
• W1993128166 hasConcept C2778354886 @default.
• W1993128166 hasConcept C2779066155 @default.
• W1993128166 hasConcept C2779672484 @default.
• W1993128166 hasConcept C30481170 @default.
• W1993128166 hasConcept C54355233 @default.
• W1993128166 hasConcept C63491729 @default.
• W1993128166 hasConcept C64894306 @default.
• W1993128166 hasConcept C73397532 @default.
• W1993128166 hasConcept C8502773 @default.
• W1993128166 hasConcept C86803240 @default.
• W1993128166 hasConcept C95444343 @default.
• W1993128166 hasConceptScore W1993128166C104317684 @default.
• W1993128166 hasConceptScore W1993128166C148196450 @default.
• W1993128166 hasConceptScore W1993128166C2778354886 @default.
• W1993128166 hasConceptScore W1993128166C2779066155 @default.
• W1993128166 hasConceptScore W1993128166C2779672484 @default.
• W1993128166 hasConceptScore W1993128166C30481170 @default.
• W1993128166 hasConceptScore W1993128166C54355233 @default.
• W1993128166 hasConceptScore W1993128166C63491729 @default.
• W1993128166 hasConceptScore W1993128166C64894306 @default.
• W1993128166 hasConceptScore W1993128166C73397532 @default.
• W1993128166 hasConceptScore W1993128166C8502773 @default.

• next