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- W1993133035 abstract "Clathrin light chain B (LCB) is a major component of clathrin coated vesicles, which are structures involved in intracellular transport. A neuron-specific isoform of LCB is generated by incorporation of a single exon (EN) using an alternative splicing mechanism that reflects the special demands of neurons, such as axonal transport and synaptic neurotransmission. Here, we demonstrate that this neuron-specific exon is developmentally regulated and is excluded in non-neuronal cells because its 5′ and 3′ splice sites deviate from the mammalian consensus sequences. A gel retardation assay indicated the presence of a developmentally regulated factor in brain that binds to the neuronal exon. In addition, EN usage is repressed by increasing the concentration of htra2-beta1, a splice factor whose isoform expression is influenced by neuronal activity. We propose that a brain-specific factor is involved in EN recognition during development and adulthood. In addition, ubiquitously expressed splicing factors such as htra2-beta1 are involved in regulating EN expression in the adult brain." @default.
- W1993133035 created "2016-06-24" @default.
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- W1993133035 creator A5064086988 @default.
- W1993133035 date "1999-01-01" @default.
- W1993133035 modified "2023-09-27" @default.
- W1993133035 title "Regulation of the neuron-specific exon of clathrin light chain B" @default.
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- W1993133035 doi "https://doi.org/10.1016/s0169-328x(98)00313-1" @default.
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