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• W1993145658 abstract "<i>Objectives:</i> Cyclooxygenase (COX) is the rate-limiting enzyme that catalyzes the conversion of arachidonic acid to prostaglandins. The purpose of the present study was to investigate the involvement of COX-2 protein in breast cancer biological behavior through its correlation with the well-known clinicopathological parameters and the expression of p53, c-erbB-2, topoisomerase IIα (topoIIα) and peroxisome proliferator-activated receptor (PPARγ) proteins, as well as its effect on patients’ survival. <i>Methods:</i> We performed immunohistochemistry to detect COX-2, estrogen receptor (ER), progesterone receptor (PR), p53, c-erbB-2, topoIIα and PPARγ proteins in 175 cases of invasive breast carcinomas. The results were elaborated by statistic analysis. <i>Results:</i> Cytoplasmic expression of COX-2 was detected in 66.9% of breast carcinoma samples and was inversely correlated with both nuclear and histological grade (p < 0.0001 and p = 0.039, respectively), whereas its association with PR was found to be positive (p = 0.016). COX-2 expression was inversely correlated with topoIIα and p53 (p = 0.033 and p = 0.002, respectively), whereas its association with PPARγ was parallel (p < 0.0001). In addition, c-erbB-2 of tumor cells was inversely correlated with COX-2 in stromal cells of the tumor (p = 0.011). Neither univariate nor multivariate analysis demonstrated any association between COX-2 expression and patient overall or disease-free survival. <i>Conclusions:</i> The current data suggest that increased expression of COX-2 may be related to breast carcinomas with less aggressive phenotype. This suggestion is further supported by the positive correlation between COX-2 and PPARγ, since the latter is considered to be indicative of a less malignant phenotype of tumor cells." @default.
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• W1993145658 date "2005-01-01" @default.
• W1993145658 modified "2023-10-10" @default.
• W1993145658 title "Overexpression of Cyclooxygenase-2 Is Associated with a Favorable Prognostic Phenotype in Breast Carcinoma" @default.
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• W1993145658 doi "https://doi.org/10.1159/000089418" @default.
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