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- W1993147265 abstract "The stereocontrolled synthesis of conformationally restricted LTD4 analogs 2a, b is described. Epoxidation of enone 4 affords a 2.4:1 mixture of trans-epoxide 5 and cis-epoxide 9. Stereocontrolled elaboration of each epoxide to final product involves stereoselective Wittig olefination to Z-olefins 6 and 10, regiospecifie epoxide ring opening with methyl mercaptoacetate to diesters 8 and 12, and saponification to 2a, b." @default.
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- W1993147265 date "1990-01-01" @default.
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- W1993147265 title "Conformationally restricted leukotriene antagonists. Stereoselective synthesis of some leukotriene D4 analogs" @default.
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- W1993147265 doi "https://doi.org/10.1016/s0040-4020(01)86751-x" @default.
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